The Role of PPAR Gamma in Systemic Sclerosis

Oral Antihyperglycemic Treatment Options for Type 2 Diabetes Mellitus

(2015) Stephen A. Brietzke   MEDICAL CLINICS OF NORTH AMERICA

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

L-Carnitine Attenuates the Development of Kidney Fibrosis in Hypertensive Rats by Upregulating PPAR- 

(2014) S. Zambrano et al.   AMERICAN JOURNAL OF HYPERTENSION

Risk of fracture with thiazolidinediones: An updated meta-analysis of randomized clinical trials

(2014) Zhong-Ning Zhu et al.   BONE

Serial Micro-CT Assessment of the Therapeutic Effects of Rosiglitazone in a Bleomycin-Induced Lung Fibrosis Mouse Model

(2014) Eun Jung Choi et al.   KOREAN JOURNAL OF RADIOLOGY

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

(2013) Jun Wei et al.   ANNALS OF THE RHEUMATIC DISEASES

Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment

(2013) E. Zardi et al.   CURRENT MEDICINAL CHEMISTRY

Molecular basis of organ fibrosis: Potential therapeutic approaches

(2013) Asish K Ghosh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, attenuates airway inflammation by inhibiting the proliferation of effector T cells in a murine model of neutrophilic asthma

(2013) Yan Zhao et al.   IMMUNOLOGY LETTERS

Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

(2013) Zhen-Zhou Zhang et al.   Journal of Translational Medicine

Cancer Risk for Patients Using Thiazolidinediones for Type 2 Diabetes: A Meta-Analysis

(2013) C. Bosetti et al.   ONCOLOGIST

PPARγAgonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?

(2013) Laurindo Ferreira da Rocha Junior et al.   PPAR Research

Synthetic cannabinoid ajulemic acid exerts potent antifibrotic effects in experimental models of systemic sclerosis

(2012) Estrella Garcia Gonzalez et al.   ANNALS OF THE RHEUMATIC DISEASES

Peroxisome proliferator-activated receptor γ agonists reduce cell proliferation and viability and increase apoptosis in systemic sclerosis fibroblasts

(2012) A. Antonelli et al.   BRITISH JOURNAL OF DERMATOLOGY

Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats

(2012) M. Samah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists

(2012) Yi-Lei Deng et al.   Hepatobiliary & Pancreatic Diseases International

IL-35 Is a Novel Responsive Anti-inflammatory Cytokine — A New System of Categorizing Anti-inflammatory Cytokines

(2012) Xinyuan Li et al.   PLoS One

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as a biomarker?

(2012) Katja Lakota et al.   ARTHRITIS RESEARCH & THERAPY

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

(2012) Feng Fang et al.   ARTHRITIS RESEARCH & THERAPY

TGFβ1 Controls PPARγExpression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts

(2012) Allan Ramirez et al.   PPAR Research

Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms

(2011) Mahnoush S. Shafiei et al.   AMERICAN JOURNAL OF PATHOLOGY

Effectiveness of rosiglitazone on bleomycin-induced lung fibrosis: Assessed by micro-computed tomography and pathologic scores

(2011) Gong Yong Jin et al.   EUROPEAN JOURNAL OF RADIOLOGY

Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients

(2011) Hiroki Arakawa et al.   EXPERIMENTAL DERMATOLOGY

Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis

(2011) Y. Masui et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis

(2011) Bradley J Rabquer et al.   ARTHRITIS RESEARCH & THERAPY

Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a “Western-style diet” by increasing PPAR α and γ expression and reducing TC, MMP-9 and Cat S levels

(2010) Yan-wen Qin et al.   ACTA PHARMACOLOGICA SINICA

Anti-inflammatory Effects of Thiazolidinediones in Human Airway Smooth Muscle Cells

(2010) Ming Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy

(2010) Jun Wei et al.   AUTOIMMUNITY REVIEWS

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

(2010) Jun Wei et al.   CURRENT OPINION IN RHEUMATOLOGY

Interferon-alpha, -beta and -gamma induce CXCL9 and CXCL10 secretion by human thyrocytes: Modulation by peroxisome proliferator-activated receptor-gamma agonists

(2010) Alessandro Antonelli et al.   CYTOKINE

Rosiglitazone inhibits migration, proliferation, and phenotypic differentiation in cultured human lung fibroblasts

(2010) Qing Lin et al.   EXPERIMENTAL LUNG RESEARCH

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Electrophilic Peroxisome Proliferator–Activated Receptor-γ Ligands Have Potent Antifibrotic Effects in Human Lung Fibroblasts

(2009) Heather E. Ferguson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activation of peroxisome proliferator-activated receptor-γ inhibits transforming growth factor-β1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro

(2009) Guo-You Zhang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

(2009) Mohit Kapoor et al.   ARTHRITIS AND RHEUMATISM

The Road From Discovery to Clinic: Adiponectin as a Biomarker of Metabolic Status

(2009) C M Kusminski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts

(2009) Guo-You Zhang et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

(2009) X. Shi-wen et al.   RHEUMATOLOGY

Connective tissue growth factor inhibits adipocyte differentiation

(2008) Joanne T. M. Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-γ

(2008) Asish K Ghosh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decreased serum IL-22 levels in patients with systemic lupus erythematosus

(2008) Hai-Feng Pan et al.   CLINICA CHIMICA ACTA

Idiopathic pulmonary fibrosis

(2008) Eric B Meltzer et al.   Orphanet Journal of Rare Diseases

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION

Fibrosis in Systemic Sclerosis

(2008) John A. Varga et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

(2007) Jami E. Milam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

CXCL10 ( ) and CCL2 ( ) chemokines in systemic sclerosis a longitudinal study

(2007) A. Antonelli et al.   RHEUMATOLOGY