Metabolic inflammation: Connecting obesity and insulin resistance

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Hematopoietic Cell-Restricted Deletion of CD36 Reduces High-Fat Diet-Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue

(2011) H. T. Nicholls et al.   DIABETES

p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance

(2011) R. Hemi et al.   DIABETES

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

(2011) Matteo Serino et al.   GUT

Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

(2011) Daniel H. Solomon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice

(2011) Yukinori Tamura et al.   Journal of Atherosclerosis and Thrombosis

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

(2011) Sufyan G. Sayyed et al.   KIDNEY INTERNATIONAL

Polymorphisms in Toll-like receptor 4 are associated with factors of the metabolic syndrome and modify the association between dietary saturated fat and fasting high-density lipoprotein cholesterol

(2011) Cristina Cuda et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro

(2011) Yi-ming Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Relation of Baseline High-Sensitivity C-Reactive Protein Level to Cardiovascular Outcomes With Rosuvastatin in the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER)

(2010) Paul M. Ridker et al.   AMERICAN JOURNAL OF CARDIOLOGY

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

(2010) Marie-Soleil Gauthier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prebiotic effects: metabolic and health benefits

(2010) Marcel Roberfroid et al.   BRITISH JOURNAL OF NUTRITION

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling

(2010) David J. Kennedy et al.   CARDIOVASCULAR RESEARCH

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides

(2010) Michiaki Abe et al.   Drug Metabolism and Pharmacokinetics

An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice

(2010) Sanshiro Tateya et al.   ENDOCRINOLOGY

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells

(2010) Hideaki Shimada et al.   FEBS LETTERS

Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance

(2010) Sophie Turban et al.   FEBS LETTERS

Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK

(2010) Alina Berdichevsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65

(2010) Hideaki Shimada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor–α

(2010) Brenda Bouter et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Epithelial crosstalk at the microbiota-mucosal interface

(2010) J. M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interplay Between Human Adipocytes and T Lymphocytes in Obesity

(2009) Carine Duffaut et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

(2009) Kazue Ohmura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue

(2009) Mayoura Keophiphath et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

(2009) Huaizhu Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue

(2009) Joseph M. Rutkowski et al.   FEBS Journal

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Variation in the Interleukin-1 Gene Family with Diabetes and Glucose Homeostasis

(2009) Kari Luotola et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice

(2008) Yukinori Tamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice

(2008) S. Franckhauser et al.   DIABETOLOGIA

Long-term Interleukin-1α Treatment Inhibits Insulin Signaling via IL-6 Production and SOCS3 Expression in 3T3-L1 Adipocytes

(2008) T. Uno et al.   HORMONE AND METABOLIC RESEARCH

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of macrophage activation in obesity-induced insulin resistance

(2008) Justin I Odegaard et al.   Nature clinical practice. Endocrinology & metabolism

Effect of pravastatin on the development of diabetes and adiponectin production

(2007) Toshiyuki Takagi et al.   ATHEROSCLEROSIS

Prospective Study of High-Sensitivity C-Reactive Protein as a Determinant of Mortality: Results from the MONICA/KORA Augsburg Cohort Study, 1984-1998

(2007) W. Koenig et al.   CLINICAL CHEMISTRY

The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice

(2007) Gunnar Loh et al.   ENVIRONMENTAL MICROBIOLOGY

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

(2007) M. Lorenzo et al.   JOURNAL OF ANIMAL SCIENCE