Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo

Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs

(2016) Sebastian Anusha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

(2016) Chakrabhavi Dhananjaya Mohan et al.   PLoS One

Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions

(2016) C. P. Baburajeev et al.   RSC Advances

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

(2015) Nanjundaswamy Ashwini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel synthetic coumarins that targets NF-κB in Hepatocellular carcinoma

(2015) Mahabaleshwaraiah Neelgundmath et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microwave-assisted synthesis, characterization and cytotoxic studies of novel estrogen receptor α ligands towards human breast cancer cells

(2015) Hanumantharayappa Bharathkumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2

(2015) V. Srinivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice

(2015) Rangaswamy Roopashree et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis

(2015) Hanumantharayappa Bharathkumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Nano-MgO and Ionic Liquid-Catalyzed ‘Green’ Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51)

(2015) Sebastian Anusha et al.   PLoS One

Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors

(2015) C. P. Baburajeev et al.   Scientific Reports

A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2

(2015) Nirvanappa C. Anilkumar et al.   PLoS One

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells

(2015) Elisabeth J. Walsby et al.   Oncotarget

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Hosadurga Kumar Keerthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species

(2014) Rajesh Chandramohanadas et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery of 6-Phenylpyrimido[4,5-b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents

(2014) Brian M. Fox et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis

(2014) Kodagahalli S. Rakesh et al.   PLoS One

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3βSignaling

(2013) Md. Jamal Uddin et al.   Oxidative Medicine and Cellular Longevity

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia

(2012) Francesca Buontempo et al.   CELL CYCLE

Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity

(2012) Kelley Salem et al.   EXPERIMENTAL HEMATOLOGY

Enhanced Antitumor Effect of Combination Therapy With Gemcitabine and Guggulsterone in Pancreatic Cancer

(2012) Dong-Won Ahn et al.   PANCREAS

Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon

(2012) Hamed Laroui et al.   PLoS One

Correction: Anti-Tumor Activity of a Novel HS-Mimetic-Vascular Endothelial Growth Factor Binding Small Molecule

(2012) Kazuyuki Sugahara et al.   PLoS One

Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative

(2011) Niloufar Ansari et al.   BIOCHIMIE

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

(2011) Muthu K. Shanmugam et al.   INTERNATIONAL JOURNAL OF CANCER

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

(2011) Muthu K. Shanmugam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A small oxazine compound as an anti-tumor agent: A novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-α

(2010) Basappa et al.   CANCER LETTERS

Identification of Novel Scaffolds for IκB Kinase Beta Inhibitor via a High Throughput Screening TR-FRET Assay

(2010) Kwang-Seok Oh et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Estradiol Suppresses NF- B Activation through Coordinated Regulation of let-7a and miR-125b in Primary Human Macrophages

(2010) A. J. Murphy et al.   JOURNAL OF IMMUNOLOGY

NF-κB in inflammatory bowel disease

(2008) I. Atreya et al.   JOURNAL OF INTERNAL MEDICINE