Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition

(2015) Abdurazzag Abusnina et al.   THROMBOSIS AND HAEMOSTASIS

Crosstalk between ERK, AKT, and cell survival

(2014) Paul Dent   CANCER BIOLOGY & THERAPY

Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells

(2014) Lucie Duluc et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling Pathways

(2013) Harish Chandra Pal et al.   PLoS One

Molecular mechanisms of the cardiovascular protective effects of polyphenols

(2012) Ramaroson Andriantsitohaina et al.   BRITISH JOURNAL OF NUTRITION

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer

(2012) Sara Arranz et al.   Nutrients

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

(2011) Abdurazzag Abusnina et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium

(2010) Matthieu Chalopin et al.   PLoS One

Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors

(2009) R. Soleti et al.   CARCINOGENESIS

The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue

(2009) Roberta L. Gonçalves et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca2+responses in endothelial cells

(2008) M Campos-Toimil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling

(2008) Sylvie Lamy et al.   CARCINOGENESIS

Protein kinase C   promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor

(2007) H. Xu et al.   CARDIOVASCULAR RESEARCH