Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model

(2011) Lu-Xia Chen et al.   CANCER BIOLOGY & THERAPY

Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy

(2011) Sudipa June Chatterjee et al.   CANCER BIOLOGY & THERAPY

Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A

(2011) Imanol Arozarena et al.   CANCER CELL

Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice

(2011) Yu-Tang Tung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer

(2010) Alexandros Daskalos et al.   CANCER

C6 ceramide potentiates curcumin-induced cell death and apoptosis in melanoma cell lines in vitro

(2010) Teng Yu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

(2010) Abdurazzag Abusnina et al.   CELLULAR SIGNALLING

Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer

(2010) Nis Giladi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

(2009) Mahmoud Alhosin et al.   BIOCHEMICAL PHARMACOLOGY

Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells

(2009) R P Sahu et al.   BRITISH JOURNAL OF CANCER

Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas

(2009) J M Pita et al.   BRITISH JOURNAL OF CANCER

The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue

(2009) Roberta L. Gonçalves et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting cancer with phosphodiesterase inhibitors

(2009) Rajkumar Savai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A Phase II Study of Carboplatin, Etoposide, and Exisulind in Patients with Extensive Small Cell Lung Cancer: CALGB 30104

(2009) Ramaswamy Govindan et al.   Journal of Thoracic Oncology

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells

(2008) Simone Reuter et al.   BIOCHEMICAL PHARMACOLOGY

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca2+responses in endothelial cells

(2008) M Campos-Toimil et al.   BRITISH JOURNAL OF PHARMACOLOGY

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE