Molecular mechanisms of the cardiovascular protective effects of polyphenols

Antihypertensive effects of the flavonoid quercetin

(2014) Francisco Perez-Vizcaino et al.   Pharmacological Reports

Combined Resveratrol, Quercetin, and Catechin Treatment Reduces Breast Tumor Growth in a Nude Mouse Model

(2014) Alexander Schlachterman et al.   Translational Oncology

Effects of Antioxidant Supplements Intervention on the Level of Plasma Inflammatory Molecules and Disease Severity of Rheumatoid Arthritis Patients

(2013) Sang-Cheol Bae et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Cardiovascular effects and molecular targets of resveratrol

(2012) Huige Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Glucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugation

(2012) Pilar Galindo et al.   PLoS One

Clinical trials of resveratrol

(2011) Ketan R. Patel et al.   Annals of the New York Academy of Sciences

Potential Mechanisms by Which Polyphenol-Rich Grapes Prevent Obesity-Mediated Inflammation and Metabolic Diseases

(2011) Chia-Chi Chuang et al.   Annual Review of Nutrition

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

(2010) Pamela Fischer-Posovszky et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat

(2010) J. Behbahani et al.   AMERICAN JOURNAL OF HYPERTENSION

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Nrf2 activation: a new target for resveratrol?

(2010) György Haskó et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells

(2010) Jovana Cvorovic et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction

(2010) Wai Mun Loke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chronic Treatment with Quercetin does not Inhibit Angiotensin-Converting Enzyme In Vivo or In Vitro

(2010) Evandro Manoel Neto-Neves et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy

(2010) Ashutosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses

(2010) Liu Kang et al.   BIOCHIMIE

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects

(2010) Serena A. Heinz et al.   BRITISH JOURNAL OF NUTRITION

A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids

(2010) Bernice Wright et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism

(2010) Silvia Wein et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels

(2010) Nicholas K.H. Khoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants

(2010) J Ølholm et al.   INTERNATIONAL JOURNAL OF OBESITY

Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation

(2010) Jia-Ni Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans- but Not Cis-Resveratrol Impairs Angiotensin-II-Mediated Vascular Inflammation through Inhibition of NF- B Activation and Peroxisome Proliferator-Activated Receptor-  Upregulation

(2010) C. Rius et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function

(2010) R.-Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice

(2010) Masahito Takikawa et al.   JOURNAL OF NUTRITION

Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155☆

(2010) Christine Boesch-Saadatmandi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Berries: emerging impact on cardiovascular health

(2010) Arpita Basu et al.   NUTRITION REVIEWS

Human endothelial dysfunction: EDCFs

(2010) Agostino Virdis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF

(2010) Valérie B. Schini-Kerth et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium

(2010) Matthieu Chalopin et al.   PLoS One

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome

(2010) Michael P. Robich et al.   SURGERY

Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice

(2010) Robert Domitrović et al.   TOXICOLOGY

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol Improves Endothelial Function

(2009) Hanrui Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-α

(2009) Mun Kyung Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Clarification of the Role of Quercetin Hydroxyl Groups in Superoxide Generation and Cell Apoptosis by Chemical Modification

(2009) Kozue SAKAO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health

(2009) Sonja K. Nicholson et al.   BRITISH JOURNAL OF NUTRITION

Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery

(2009) S Suri et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR1 and PAR4 in platelets

(2009) L Navarro-Núñez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase

(2009) Jung Yeon Kwon et al.   CARCINOGENESIS

Resveratrol: A Multifunctional Compound Improving Endothelial Function

(2009) Huige Li et al.   CARDIOVASCULAR DRUGS AND THERAPY

Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells

(2009) Chun-ye Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Prevention of Atherosclerosis by Interference with the Vascular Nitric Oxide System

(2009) Huige Li et al.   CURRENT PHARMACEUTICAL DESIGN

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

The Oral Microbiota: Living with a Permanent Guest

(2009) Maria Avila et al.   DNA AND CELL BIOLOGY

Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats

(2009) Miguel Romero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases

(2009) Leyre Navarro-Núñez et al.   FITOTERAPIA

Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-α-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin

(2009) Mun Kyung Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Some Phenolic Compounds Increase the Nitric Oxide Level in Endothelial Cells in Vitro

(2009) Maaike M. Appeldoorn et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Antihypertensive Effects of Quercetin in a Salt-sensitive Model of Hypertension

(2009) I Mackraj et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa

(2009) Deyanira Ojeda et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroprotective Effects of Onion Extract and Quercetin Against Ischemic Neuronal Damage in the Gerbil Hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF MEDICINAL FOOD

sPhospholipase A2 is inhibited by anthocyanidins

(2009) Andrea Dreiseitel et al.   JOURNAL OF NEURAL TRANSMISSION

eNOS Activation Induced by a Polyphenol-Rich Grape Skin Extract in Porcine Coronary Arteries

(2009) Socorro Vanesca Frota Madeira et al.   JOURNAL OF VASCULAR RESEARCH

Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family

(2009) Nicole Teller et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SIRT1 and insulin resistance

(2009) Fengxia Liang et al.   Nature Reviews Endocrinology

Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats

(2009) Chao Li et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors

(2009) M.C. Saleh et al.   NEUROSCIENCE

Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats

(2009) Felicia Rivera et al.   NEUROTOXICITY RESEARCH

AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

(2009) Jin-Taek Hwang et al.   New Biotechnology

Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols

(2009) Modou O. Kane et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular mechanisms underlying the activation of eNOS

(2009) Ingrid Fleming   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Red Wine Polyphenols Prevent Metabolic and Cardiovascular Alterations Associated with Obesity in Zucker Fatty Rats (Fa/Fa)

(2009) Abdelali Agouni et al.   PLoS One

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

(2008) Ryohei Miyazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC

(2008) Miguel Romero et al.   ATHEROSCLEROSIS

Inhibition of proteasome activity by anthocyanins and anthocyanidins

(2008) Andrea Dreiseitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

(2008) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

(2008) Leonor Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Acute treatment with red wine polyphenols protects from ischemia-induced excitotoxicity, energy failure and oxidative stress in rats

(2008) Marie-Françoise Ritz et al.   BRAIN RESEARCH

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia

(2008) Seema Yousuf et al.   BRAIN RESEARCH

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways

(2008) J.-Y. Deng et al.   DIABETES

Resveratrol stimulates nitric oxide production by increasing estrogen receptor α-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells

(2008) Carolyn M. Klinge et al.   FASEB JOURNAL

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

(2008) Tiziano M. Scarabelli et al.   FEBS LETTERS

Differential roles of PKCα and PKCɛ in controlling the gene expression of Nox4 in human endothelial cells

(2008) Hui Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structures and Antioxidant Activity of Anthocyanins in Many Accessions of Eggplant and Its Related Species

(2008) Keiko Azuma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Preventive Effects of Nutritional Doses of Polyphenolic Molecules on Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of Osteopontin and Oxidative Stress

(2008) Thibault Sutra et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium

(2008) S. Varma Penumathsa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Energy Restriction Impairs Natural Killer Cell Function and Increases the Severity of Influenza Infection in Young Adult Male C57BL/6 Mice

(2008) Barry W. Ritz et al.   JOURNAL OF NUTRITION

A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol

(2008) Ljiljana Gojkovic-Bukarica et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling

(2008) P. Wohlfart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors

(2008) WenPeng Dong et al.   JOURNAL OF VASCULAR SURGERY

Quercetin Ameliorates Metabolic Syndrome and Improves the Inflammatory Status in Obese Zucker Rats

(2008) Leonor Rivera et al.   Obesity

Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin

(2007) Istvan Lekli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase

(2007) Yvonne Steffen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro

(2007) Lonneke C. Wilms et al.   TOXICOLOGY IN VITRO