Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease

Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

(2014) Konstantin Neumann et al.   IMMUNITY

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis

(2014) Sonia Nasi et al.   JOINT BONE SPINE

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats

(2014) Congshan Jiang et al.   ARTHRITIS RESEARCH & THERAPY

Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1

(2014) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis

(2014) Ryan Thwaites et al.   Frontiers in Immunology

Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes

(2013) Seon-Yeong Lee et al.   IMMUNOLOGY

DNA-dependent Activator of Interferon-regulatory Factors (DAI) Promotes Lupus Nephritis by Activating the Calcium Pathway

(2013) Weijuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation

(2013) Weijuan Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Do Changing Toll-like Receptor Profiles in Different Layers and Grades of Osteoarthritis Cartilage Reflect Disease Severity?

(2013) G. Barreto et al.   JOURNAL OF RHEUMATOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Role of Interleukin-1 Inhibitors in the Management of Gout

(2013) Tran H. Tran et al.   PHARMACOTHERAPY

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications

(2013) Valérie Gagné et al.   ARTHRITIS RESEARCH & THERAPY

Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

(2013) Julio E. Molineros et al.   PLoS Genetics

Synovium and the Innate Inflammatory Network in Osteoarthritis Progression

(2013) Ru Liu-Bryan   Current Rheumatology Reports

Functions of NOD-Like Receptors in Human Diseases

(2013) Yifei Zhong et al.   Frontiers in Immunology

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

(2012) Anjali Nair et al.   ARTHRITIS AND RHEUMATISM

Role of S100A12 in the pathogenesis of osteoarthritis

(2012) Motoshige Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

The pathogenesis of systemic lupus erythematosus—an update

(2012) Jinyoung Choi et al.   CURRENT OPINION IN IMMUNOLOGY

New developments in Toll-like receptor targeted therapeutics

(2012) Dympna J Connolly et al.   CURRENT OPINION IN PHARMACOLOGY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction

(2012) Marie-Christophe Boissier et al.   JOURNAL OF AUTOIMMUNITY

TLR5, a Novel and Unidentified Inflammatory Mediator in Rheumatoid Arthritis that Correlates with Disease Activity Score and Joint TNF-  Levels

(2012) N. D. Chamberlain et al.   JOURNAL OF IMMUNOLOGY

Association of a functional polymorphism in the promoter region of TLR-3 with osteoarthritis: A two-stage case-control study

(2012) Hsin-Yi Yang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation

(2012) P.S. Chockalingam et al.   OSTEOARTHRITIS AND CARTILAGE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance

(2012) Saba Alzabin et al.   ARTHRITIS RESEARCH & THERAPY

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide

(2011) Mar Carrión et al.   ARTHRITIS AND RHEUMATISM

The pattern-recognition receptor nucleotide-binding oligomerization domain-containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts

(2011) Kazuhiro Yokota et al.   ARTHRITIS AND RHEUMATISM

Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

(2011) S-Y Chen et al.   GENE THERAPY

The PYHIN protein family as mediators of host defenses

(2011) Stefan A. Schattgen et al.   IMMUNOLOGICAL REVIEWS

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

The (−1486T/C) promoter polymorphism of the TLR-9 gene is associated with end-stage knee osteoarthritis in a Chinese population

(2011) Sui-Lung Su et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

(2011) Sinéad Nic An Ultaigh et al.   ARTHRITIS RESEARCH & THERAPY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Interferon Alpha in Systemic Lupus Erythematosus

(2010) Timothy B. Niewold et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

CD14 is a coreceptor of Toll-like receptors 7 and 9

(2010) Christoph L. Baumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gout therapeutics: new drugs for an old disease

(2010) Christopher M Burns et al.   LANCET

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Hydroxychloroquine in SLE: old drug, new perspectives

(2010) Thomas Dörner   Nature Reviews Rheumatology

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Erosive osteoarthritis of the hand: clinical experience with anakinra

(2009) L Bacconnier et al.   ANNALS OF THE RHEUMATIC DISEASES

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

(2009) D. H. Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the epidemiology of gout

(2009) M. Doherty   RHEUMATOLOGY

Toll-like receptors and NOD-like receptors in rheumatic diseases

(2009) William J McCormack et al.   ARTHRITIS RESEARCH & THERAPY

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production

(2008) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS AND RHEUMATISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE