The clinical relevance of animal models in Sjögren’s syndrome: the interferon signature from mouse to man

TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner

(2014) Attila Szabo et al.   IMMUNOLOGY AND CELL BIOLOGY

Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome

(2014) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

(2014) S. W. Jackson et al.   JOURNAL OF IMMUNOLOGY

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

Interleukin-7 and Toll-Like Receptor 7 Induce Synergistic B Cell and T Cell Activation

(2014) Angela Bikker et al.   PLoS One

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

(2014) B. Desnues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

(2014) Avram Goldberg et al.   ARTHRITIS RESEARCH & THERAPY

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study

(2013) Xavier Mariette et al.   ANNALS OF THE RHEUMATIC DISEASES

MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome

(2013) Naomi I Maria et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-7 Enhances the Th1 Response to Promote the Development of Sjögren's Syndrome-like Autoimmune Exocrinopathy in Mice

(2013) Jun-O Jin et al.   ARTHRITIS AND RHEUMATISM

Development of Systemic Lupus Erythematosus in NZM 2328 Mice in the Absence of any Single BAFF Receptor

(2013) Chaim O. Jacob et al.   ARTHRITIS AND RHEUMATISM

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

(2013) Fu-Gang Zhu et al.   AUTOIMMUNITY

BXSB/MpJ-Yaamice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the lacrimal fluid

(2013) Keigo Kosenda et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Transient depletion of CD4+ CD25+regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice

(2013) Jason S. Ellis et al.   IMMUNOLOGY

Autoantibodies Present Before Symptom Onset in Primary Sjögren Syndrome

(2013) Roland Jonsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Type I Interferon Receptor Deficiency Prevents Murine Sjögren’s Syndrome

(2013) B.M Szczerba et al.   JOURNAL OF DENTAL RESEARCH

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Future prospects in biologic therapy for systemic lupus erythematosus

(2013) William Stohl   Nature Reviews Rheumatology

Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome

(2013) Nicolas Delaleu et al.   ARTHRITIS RESEARCH & THERAPY

The Interferon-Signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases

(2013) Cuong Quoc Nguyen et al.   Frontiers in Immunology

Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

(2012) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

The interferon signature in autoimmune diseases

(2012) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling

(2012) Seshagiri-Rao Nandula et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

New insights into mechanisms of therapeutic effects of antimalarial agents in SLE

(2012) Daniel J. Wallace et al.   Nature Reviews Rheumatology

Unraveling the Pathophysiology of Sjogren Syndrome-Associated Dry Eye Disease

(2012) Cuong Q. Nguyen et al.   Ocular Surface

Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

(2012) Nienke Roescher et al.   PLoS One

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

(2012) J. C. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome Analysis of the Interferon-Signature Defining the Autoimmune Process of Sjögren’s Syndrome

(2012) A. B. Peck et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

(2012) Hongen Yin et al.   ARTHRITIS RESEARCH & THERAPY

Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model

(2012) Steve Horvath et al.   ARTHRITIS RESEARCH & THERAPY

Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy

(2012) Byung Lee et al.   ARTHRITIS RESEARCH & THERAPY

B-cell activating factor targeted therapy and lupus

(2012) Alexis Boneparth et al.   ARTHRITIS RESEARCH & THERAPY

Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome

(2011) E. Theander et al.   ANNALS OF THE RHEUMATIC DISEASES

The effect of regulatory T-cell depletion on the spectrum of organ-specific autoimmune diseases in nonobese diabetic mice at different ages

(2011) Mami Nakahara et al.   AUTOIMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

TLR9 and TLR7 agonists mediate distinct type I IFN responses in humans and nonhuman primates in vitro and in vivo

(2011) Montserrat Puig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjögren’s syndrome

(2011) N Roescher et al.   ORAL DISEASES

Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren’s syndrome-like disease

(2011) S-R Nandula et al.   ORAL DISEASES

Activation of the Alternative NFκB Pathway Improves Disease Symptoms in a Model of Sjogren's Syndrome

(2011) Adi Gilboa-Geffen et al.   PLoS One

Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome

(2011) Roy A Fava et al.   ARTHRITIS RESEARCH & THERAPY

Sjögren's syndrome: studying the disease in mice

(2011) Nicolas Delaleu et al.   ARTHRITIS RESEARCH & THERAPY

Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity

(2011) Qian Wu et al.   ARTHRITIS RESEARCH & THERAPY

Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice

(2010) Meera Ramanujam et al.   ARTHRITIS AND RHEUMATISM

IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer

(2010) Cuong Q Nguyen et al.   LABORATORY INVESTIGATION

Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy

(2009) Katja Schenke-Layland et al.   EXPERIMENTAL EYE RESEARCH

Peripheral blood gene expression profiling in Sjögren's syndrome

(2009) E S Emamian et al.   GENES AND IMMUNITY

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY

Systemic increase in type I interferon activity in Sjögren's syndrome: A putative role for plasmacytoid dendritic cells

(2008) Manon E. Wildenberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE