Interleukin-7 Enhances the Th1 Response to Promote the Development of Sjögren's Syndrome-like Autoimmune Exocrinopathy in Mice

Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation

(2012) Olutayo Odusanwo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjögren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity

(2012) A Bikker et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-IL-7 receptor-  reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function

(2012) L.-F. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7R 

(2012) A. Bikker et al.   RHEUMATOLOGY

A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome

(2011) Kaleb M. Pauley et al.   ARTHRITIS AND RHEUMATISM

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Upregulated IL-7 Receptor   Expression on Colitogenic Memory CD4+ T Cells May Participate in the Development and Persistence of Chronic Colitis

(2011) T. Shinohara et al.   JOURNAL OF IMMUNOLOGY

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren’s syndrome-like disease

(2011) S-R Nandula et al.   ORAL DISEASES

Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade

(2011) Rosana Gonzalez-Quintial et al.   PLoS One

IL-7 Promotes TH1 Development and Serum IL-7 Predicts Clinical Response to Interferon-  in Multiple Sclerosis

(2011) L.-F. Lee et al.   Science Translational Medicine

Cytokines in Sjogren's syndrome: potential therapeutic targets

(2010) N. Roescher et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation

(2010) A. Bikker et al.   ARTHRITIS AND RHEUMATISM

Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators

(2010) Sarita A. Y. Hartgring et al.   ARTHRITIS AND RHEUMATISM

Commensal microflora and interferon-γ promote steady-state interleukin-7 production in vivo

(2010) Shabnam Shalapour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modeling Sjögren's syndrome with Id3 conditional knockout mice

(2010) Zengli Guo et al.   IMMUNOLOGY LETTERS

Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function

(2010) Umesh S. Deshmukh et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

(2010) Jung-Hyun Park et al.   NATURE IMMUNOLOGY

Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

(2010) Michael Voulgarelis et al.   Nature Reviews Rheumatology

CXCR3, Inflammation, and Autoimmune Diseases

(2009) Stéphanie Lacotte et al.   Annals of the New York Academy of Sciences

Sjögren’s syndrome: An old tale with a new twist

(2009) Byung Ha Lee et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Hepatic Interleukin-7 Expression Regulates T Cell Responses

(2009) Yukihisa Sawa et al.   IMMUNITY

X-linked Foxp3 (Scurfy) Mutation Dominantly Inhibits Submandibular Gland Development and Inflammation Respectively through Adaptive and Innate Immune Mechanisms

(2009) R. Sharma et al.   JOURNAL OF IMMUNOLOGY

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

(2009) Marc Pellegrini et al.   NATURE MEDICINE

Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse

(2009) Cuong Q Nguyen et al.   ARTHRITIS RESEARCH & THERAPY

Proinflammatory cytokines tumor necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line

(2008) Olga J. Baker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: Findings in humans and mice

(2008) Cuong Q. Nguyen et al.   ARTHRITIS AND RHEUMATISM

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

(2008) T. Calzascia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-7 in rheumatoid arthritis

(2008) S. M. Churchman et al.   RHEUMATOLOGY