B-cell activating factor targeted therapy and lupus

Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus

(2012) William Stohl et al.   ARTHRITIS AND RHEUMATISM

Effect of Belimumab on Vaccine Antigen Antibodies to Influenza, Pneumococcal, and Tetanus Vaccines in Patients with Systemic Lupus Erythematosus in the BLISS-76 Trial

(2012) W. WINN CHATHAM et al.   JOURNAL OF RHEUMATOLOGY

Selective APRIL Blockade Delays Systemic Lupus Erythematosus in Mouse

(2012) Bertrand Huard et al.   PLoS One

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Dispensability of APRIL to the development of systemic lupus erythematosus in NZM 2328 mice

(2011) Chaim O. Jacob et al.   ARTHRITIS AND RHEUMATISM

Plasma cells in systemic lupus erythematosus: The long and short of it all

(2011) Zheng Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A small CD11b+human B1 cell subpopulation stimulates T cells and is expanded in lupus

(2011) Daniel O. Griffin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70−

(2011) Daniel O. Griffin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

BAFF and selection of autoreactive B cells

(2011) Zheng Liu et al.   TRENDS IN IMMUNOLOGY

Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome

(2011) Keiko Yoshimoto et al.   ARTHRITIS RESEARCH & THERAPY

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

Targeting BAFF in autoimmunity

(2010) Anne Davidson   CURRENT OPINION IN IMMUNOLOGY

B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor

(2010) Fabienne Mackay et al.   IMMUNOLOGICAL REVIEWS

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

(2010) Patrizia Scapini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

Basophils and the T helper 2 environment can promote the development of lupus nephritis

(2010) Nicolas Charles et al.   NATURE MEDICINE

B-cell Activating Factor of the Tumour Necrosis Factor Family Expression in Blood Monocytes and T Cells from Patients with Primary Sjögren’s Syndrome

(2010) F. Lavie et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus

(2009) A M Jacobi et al.   ANNALS OF THE RHEUMATIC DISEASES

A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus

(2009) Daniel J. Wallace et al.   ARTHRITIS AND RHEUMATISM

Novel evidence-based systemic lupus erythematosus responder index

(2009) Richard A. Furie et al.   ARTHRITIS AND RHEUMATISM

Effect of long-term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study

(2009) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

(2009) Michael P. Cancro et al.   JOURNAL OF CLINICAL INVESTIGATION

An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus

(2009) C Pena-Rossi et al.   LUPUS

Phenotypic Characterization of Autoreactive B Cells—Checkpoints of B Cell Tolerance in Patients with Systemic Lupus Erythematosus

(2009) Annett M. Jacobi et al.   PLoS One

BAFF and the plasticity of peripheral B cell tolerance

(2008) Jason E Stadanlick et al.   CURRENT OPINION IN IMMUNOLOGY

Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

(2008) Q. Lai Kwan Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact

(2008) J. L. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA