Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

(2013) Hang-Lung Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Statins: Perspectives in cancer therapeutics

(2013) Laurent Corcos et al.   DIGESTIVE AND LIVER DISEASE

Segmenting the Etiological Agent of Schistosomiasis for High-Content Screening

(2013) D. E. Asarnow et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis

(2012) Hyokyeong Lee et al.   BMC GENOMICS

Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents

(2012) M. Thurnher et al.   CLINICAL CANCER RESEARCH

Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis

(2012) Francesca Tamarozzi et al.   Parasites & Vectors

Apoptosis phenomenon in the schistosomulum and adult worm life cycle stages of Schistosoma japonicum

(2012) Hongxiao Han et al.   PARASITOLOGY INTERNATIONAL

Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infections

(2012) Joshua D. Ochocki et al.   MedChemComm

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

(2012) Ross A. Paveley et al.   PLoS Neglected Tropical Diseases

Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC–MS/MS

(2011) Linda Henneman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Schistosomiasis

(2011) Conor R. Caffrey et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate

(2011) B. M. Wasko et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The mevalonate pathway in C. elegans

(2011) Manish Rauthan et al.   Lipids in Health and Disease

Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

(2011) Norbert Berndt et al.   Nature Protocols

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Potential Drug Development Candidates for Human Soil-Transmitted Helminthiases

(2011) Piero Olliaro et al.   PLoS Neglected Tropical Diseases

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum

(2010) Véronique Parquet et al.   MALARIA JOURNAL

Origins and Early Evolution of the Mevalonate Pathway of Isoprenoid Biosynthesis in the Three Domains of Life

(2010) J. Lombard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dysregulation of the mevalonate pathway promotes transformation

(2010) J. W. Clendening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

(2010) Gregory J. Crowther et al.   PLoS Neglected Tropical Diseases

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

(2010) Saša Štefanić et al.   PLoS Neglected Tropical Diseases

The Global Atlas of Helminth Infection: Mapping the Way Forward in Neglected Tropical Disease Control

(2010) Simon Brooker et al.   PLoS Neglected Tropical Diseases

Biotechnological production and applications of statins

(2009) Javier Barrios-González et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs

(2009) M. J. DOENHOFF et al.   PARASITOLOGY

The Formin-Homology Protein SmDia Interacts with the Src Kinase SmTK and the GTPase SmRho1 in the Gonads of Schistosoma mansoni

(2009) Thomas Quack et al.   PLoS One

SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni

(2009) Jan Dvořák et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Pleiotropic effects of statin therapy: molecular mechanisms and clinical results

(2008) Chao-Yung Wang et al.   TRENDS IN MOLECULAR MEDICINE