Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells

(2010) Hang Zheng et al.   CANCER LETTERS

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

(2010) N Berndt et al.   CELL DEATH AND DIFFERENTIATION

Evaluation of Alkyne-Modified Isoprenoids as Chemical Reporters of Protein Prenylation

(2010) Amanda J. DeGraw et al.   Chemical Biology & Drug Design

A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting

(2010) Fredrick O. Onono et al.   MOLECULAR & CELLULAR PROTEOMICS

The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways

(2010) C.-K. Kim et al.   MOLECULAR PHARMACOLOGY

The chemical toolbox for monitoring protein fatty acylation and prenylation

(2010) Rami N Hannoush et al.   Nature Chemical Biology

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older

(2009) J.-L. Harousseau et al.   BLOOD

Phase II Trial of Tipifarnib plus Neoadjuvant Doxorubicin-Cyclophosphamide in Patients with Clinical Stage IIB-IIIC Breast Cancer

(2009) J. A. Sparano et al.   CLINICAL CANCER RESEARCH

A novel approach to tag and identify geranylgeranylated proteins

(2009) Lai N. Chan et al.   ELECTROPHORESIS

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

(2009) A. Kazi et al.   MOLECULAR AND CELLULAR BIOLOGY

Palmitoylation cycles and regulation of protein function (Review)

(2009) Steinunn Baekkeskov et al.   MOLECULAR MEMBRANE BIOLOGY

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

(2009) Uyen T T Nguyen et al.   Nature Chemical Biology

Phase I Study of Alternate-Week Administration of Tipifarnib in Patients with Myelodysplastic Syndrome

(2008) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

(2008) K. J. Mavrakis et al.   GENES & DEVELOPMENT

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caution! Analyze transcripts from conditional knockout alleles

(2008) Shao H. Yang et al.   TRANSGENIC RESEARCH