Mice Deficient in Sfrp1 Exhibit Increased Adiposity, Dysregulated Glucose Metabolism, and Enhanced Macrophage Infiltration

Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis

(2013) Jessy Présumey et al.   ANNALS OF THE RHEUMATIC DISEASES

PAI-1 4G/5G Polymorphism Contributes to Cancer Susceptibility: Evidence from Meta-Analysis

(2013) Shangqian Wang et al.   PLoS One

The Adipocytokine Nampt and Its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion

(2013) Robert Spinnler et al.   PLoS One

Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio

(2013) Carsten Stuckenholz et al.   PLoS One

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

Loss of sfrp1 promotes ductal branching in the murine mammary gland

(2012) Kelly J Gauger et al.   BMC DEVELOPMENTAL BIOLOGY

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

(2012) Taman Mahdi et al.   Cell Metabolism

Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

(2012) Wenzhong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

(2012) Hiroyuki Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells

(2012) Sarah C. Bowlby et al.   PLoS One

sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration

(2011) Gema Martin-Manso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Secreted Frizzled-Related Protein-1 Improves Postinfarction Scar Formation Through a Modulation of Inflammatory Response

(2011) Laurent Barandon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SFRP1 reduction results in an increased sensitivity to TGF-β signaling

(2011) Kelly J Gauger et al.   BMC CANCER

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function

(2011) P. W. Caton et al.   DIABETOLOGIA

Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

(2011) Takumi Yoshino et al.   INTERNAL MEDICINE

Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts

(2011) Eveline Boudin et al.   MOLECULAR GENETICS AND METABOLISM

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis

(2011) Pilar Esteve et al.   NATURE NEUROSCIENCE

Impact of Metabolic Regulators on the Expression of the Obesity Associated Genes FTO and NAMPT in Human Preadipocytes and Adipocytes

(2011) Daniela Friebe et al.   PLoS One

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

PBEF1/NAmPRTase/Visfatin: A potential malignant astrocytoma/glioblastoma serum marker with prognostic value

(2010) P. Sreekanth Reddy et al.   CANCER BIOLOGY & THERAPY

Genetic control ofde novolipogenesis: role in diet-induced obesity

(2010) Maggie S. Strable et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity

(2010) C Lagathu et al.   INTERNATIONAL JOURNAL OF OBESITY

Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice

(2010) Mehmet M. Altintas et al.   JOURNAL OF LIPID RESEARCH

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

(2010) N. Ouchi et al.   SCIENCE

Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis

(2009) Kelly J Gauger et al.   Cancer Cell International

The Wnt pathway: A macrophage effector molecule that triggers inflammation

(2009) Claudia P. Pereira et al.   Current Atherosclerosis Reports

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

(2009) Junghyo Jo et al.   PLoS Computational Biology

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

(2008) Caroline M. Apovian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION

Wnt4 and Wnt5a promote adipocyte differentiation

(2008) Makoto Nishizuka et al.   FEBS LETTERS

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

(2008) Michelangelo Fiorentino et al.   LABORATORY INVESTIGATION