Nicotinamide Phosphoribosyl Transferase (Nampt) Is Required for De Novo Lipogenesis in Tumor Cells

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Nondegradative Ubiquitination of Apoptosis Inducing Factor (AIF) by X-Linked Inhibitor of Apoptosis at a Residue Critical for AIF-Mediated Chromatin Degradation

(2011) Eric M. Lewis et al.   BIOCHEMISTRY

Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells

(2011) Keita Nakane et al.   INTERNATIONAL JOURNAL OF UROLOGY

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

(2011) Ramkumar Rajendran et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

PBEF1/NAmPRTase/Visfatin: A potential malignant astrocytoma/glioblastoma serum marker with prognostic value

(2010) P. Sreekanth Reddy et al.   CANCER BIOLOGY & THERAPY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

(2010) Jianjun Bao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic Compound

(2010) Tracey C. Fleischer et al.   CHEMISTRY & BIOLOGY

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Comprehensive lysine acetylomes emerging from bacteria to humans

(2010) Go-Woon Kim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment

(2009) Nica M. Borradaile et al.   AGING CELL

SIRT1 markedly extends replicative lifespan if the NAD+salvage pathway is enhanced

(2009) Cynthia Ho et al.   FEBS LETTERS

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

(2009) M. Watson et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

(2008) Keitaro Kojima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anticancer agent CHS-828 inhibits cellular synthesis of NAD

(2008) Uffe Høgh Olesen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

(2008) D. M. Taylor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity

(2008) Swami R. Narala et al.   MOLECULAR BIOLOGY OF THE CELL

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE

Nampt: linking NAD biology, metabolism and cancer

(2008) Antje Garten et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM