Article
Oncology
Meena U. Rajagopal, Shivani Bansal, Prabhjit Kaur, Shreyans K. Jain, Tatiana Altadil, Charles P. Hinzman, Yaoxiang Li, Joanna Moulton, Baldev Singh, Sunil Bansal, Siddheshwar Kisan Chauthe, Rajbir Singh, Partha P. Banerjee, Mark Mapstone, Massimo S. Fiandaca, Howard J. Federoff, Keith Unger, Jill P. Smith, Amrita K. Cheema
Summary: Pancreatic cancer is an aggressive disease with poor outcomes due to late diagnosis. Metabolomics approach revealed metabolic changes that could potentially improve clinical outcomes.
Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Huiyan Eng, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Kanchugarakoppal S. Rangappa, Gautam Sethi, Alan Prem Kumar, Kwang Seok Ahn
Summary: This study demonstrates that 2,3,5,6-Tetramethylpyrazine (TMP) can suppress the EMT program in colon cancer cells by regulating MnSOD and related proteins, and inhibit the proliferation, migration, and invasion of tumor cells.
Article
Cell Biology
Chenqiang Jia, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang
Summary: EMT gene signatures are positively correlated with GSDME levels in human cancers, and EMT plays a causal role in the reversible upregulation of GSDME. Core EMT-activating transcription factors ZEB1/2 directly drive the transcriptional activation of GSDME. Elevated GSDME in mesenchymally transdifferentiated derivatives can induce pyroptotic cell death and cytokine release upon exposure to antineoplastic drugs, suggesting therapeutic potential for mesenchymal malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bo Xiao, Liyan Liu, Zhuoyuan Chen, Aoyu Li, Pingxiao Wang, Cheng Xiang, Yi Zeng, Hui Li, Tao Xiao
Summary: This study constructed an EMT-related lncRNA signature for melanoma patients by analyzing RNA expression data and clinical features, indicating that these lncRNAs can function as potential independent prognostic biomarkers for melanoma survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Oncology
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter Ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas
Summary: TGF beta promotes sternness and invasiveness in breast cancer cells by inducing epithelial-mesenchymal transition (EMT) and metastatic colonization by inducing mesenchymal-epithelial transition (MET). However, whether TGF beta can promote both sternness and invasiveness simultaneously via EMT remains unclear.
MOLECULAR ONCOLOGY
(2022)
Article
Immunology
Zhishang Meng, Yanzhu Chen, Wenyi Wu, Bin Yan, Lusi Zhang, Huihui Chen, Yongan Meng, Youling Liang, Xiaoxi Yao, Jing Luo
Summary: This study identified PRRX1 as a reliable TME-related biomarker that can predict survival and provide new insights into therapy for uveal melanoma (UM) patients. The results showed that increased PRRX1 expression is independently associated with poorer overall survival and metastasis-free survival in UM patients, and PRRX1 promotes malignant progression by facilitating epithelial-mesenchymal transition. These findings suggest that PRRX1 may be a potential target for UM therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lucas Eduardo Botelho de Souza, Fernanda Ursoli Ferreira, Carolina Hassibe Thome, Heloisa Brand, Maristela Delgado Orellana, Vitor Marcel Faca, Aparecida Maria Fontes, Dimas Tadeu Covas
Summary: Melanoma cells have the capability to activate an EMT-like program and acquire metastatic traits through distinct pathways induced by MSCs' secretome, both in mouse and human cells.
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Medicinal
Paola De Cicco, Giuseppe Ercolano, Gian Carlo Tenore, Angela Ianaro
Summary: This study investigated the effects of an extract from olive tree leaves (OLE) on metastatic melanoma, a highly aggressive and deadly form of skin cancer. The results showed that OLE inhibited melanoma cell proliferation, migration, invasion, and colonies formation both in vitro and in vivo. These effects were attributed to the targeting of mitogen-activated protein kinase and PI3K pathways. The findings suggest that OLE has the potential to be a new add-on therapy for the management of metastatic melanoma.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Guannan Zhao, Wenjing Zhang, Peixin Dong, Hidemichi Watari, Yuqi Guo, Lawrence M. Pfeffer, Gabor Tigyi, Junming Yue
Summary: The highly expressed EIF5A2 in ovarian cancer is associated with poor survival and promotes tumor metastasis by inducing EMT and activating the TGFβ pathway. Knockout of EIF5A2 inhibits ovarian tumor growth and metastasis, demonstrating EIF5A2 as an important regulator in controlling ovarian cancer progression.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Guodong Cao, Pengping Li, Xiaobo He, Mengyao Jin, Mengying Li, Sihan Chen, Xin Xu, Qiang Sun, Maoming Xiong, Bo Chen
Summary: High expression of FHL3 is associated with gastric cancer progression and chemotherapy resistance by regulating EMT and inhibiting ubiquitination to promote tumor metastasis. Mechanistically, this process is mediated through activation of MAPK and PI3K pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Review
Immunology
M. Fathimath Muneesa, Sadiya B. Shaikh, T. M. Jeena, Yashodhar P. Bhandary
Summary: Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease characterized by lung tissue scarring leading to respiratory failure. The exact etiology of the disease is unclear and the role of inflammation in its development is controversial. Inflammatory cytokines play a critical role in initiating the inflammatory response in the lungs, contributing to the pathogenesis of IPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Luis Teixeira, Jacques Medioni, Julie Garibal, Olivier Adotevi, Ludovic Doucet, Marie-Agnes Dragon Durey, Zineb Ghrieb, Jean-Jacques Kiladjian, Mara Brizard, Caroline Laheurte, Maria Wehbe, Elodie Pliquet, Marie Escande, Remy Defrance, Stephane Culine, Stephane Oudard, Simon Wain-Hobson, Valerie Doppler, Thierry Huet, Pierre Langlade-Demoyen
CLINICAL CANCER RESEARCH
(2020)
Article
Immunology
Connie B. Gilfillan, Chensu Wang, Mona O. Mohsen, Nathalie Rufer, Michael Hebeisen, Mathilde Allard, Gregory Verdeil, Darrell J. Irvine, Martin F. Bachmann, Daniel E. Speiser
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Marine M. Leblond, Laure Tille, Sina Nassiri, Connie B. Gilfillan, Claire Imbratta, Martina Schmittnaegel, Carola H. Ries, Daniel E. Speiser, Gregory Verdeil
CANCER IMMUNOLOGY RESEARCH
(2020)
Letter
Immunology
Alejandra Gomez-Cadena, Laurie Spehner, Marie Kroemer, Myriam Ben Khelil, Kevin Bouiller, Gregory Verdeil, Sara Trabanelli, Christophe Borg, Romain Loyon, Camilla Jandus
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Microbiology
Oceane Dufies, Anne Doye, Johan Courjon, Cedric Torre, Gregory Michel, Celine Loubatier, Arnaud Jacquel, Paul Chaintreuil, Alissa Majoor, Rodolphe R. Guinamard, Alexandre Gallerand, Pedro H. V. Saavedra, Els Verhoeyen, Amaury Rey, Sandrine Marchetti, Raymond Ruimy, Dorota Czerucka, Mohamed Lamkanfi, Benedicte F. Py, Patrick Munro, Orane Visvikis, Laurent Boyer
Summary: Inflammasomes are critical signalling platforms assembled in response to infection or sterile inflammation, with NLRP3 playing a key role in activating the inflammasome. The activation of NLRP3 inflammasome is tightly controlled both transcriptionally and post-translationally, but the mechanisms regulating its activation remain poorly understood.
NATURE MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Paul Oster, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, Marine M. Leblond, Meriem Messaoudene, Elisavet Machremi, Emeric Limagne, Francois Ghiringhelli, Bertrand Routy, Gregory Verdeil, Dominique Velin
Summary: This study revealed that Helicobacter pylori infection may reduce the efficacy of cancer immunotherapies, as demonstrated in mouse models and human clinical studies.
Article
Immunology
Valentin Sencio, Alexandre Gallerand, Marina Gomes Machado, Lucie Deruyter, Severine Heumel, Daphnee Soulard, Johanna Barthelemy, Celine Cuinat, Angelica T. Vieira, Adeline Barthelemy, Luciana P. Tavares, Rodolphe Guinamard, Stoyan Ivanov, Corinne Grangette, Mauro M. Teixeira, Benoit Foligne, Isabelle Wolowczuk, Ronan Le Goffic, Muriel Thomas, Francois Trottein
Summary: Viral respiratory infections can lead to extrapulmonary complications, such as gut disorders, which have a potentially critical impact on health. Gut inflammation and barrier dysfunction during influenza are associated with changes in gut microbiota composition and decreased production of SCFAs, both of which can be partially countered by SCFA supplementation.
INFECTION AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Alexandre Gallerand, Marion Stunault, Johanna Merlin, Hannah P. Luehmann, Deborah H. Sultan, Maria M. Firulyova, Virginie Magnone, Narges Khedher, Antoine Jalil, Bastien Dolfi, Alexia Castiglione, Adelie Dumont, Marion Ayrault, Nathalie Vaillant, Jerome Gilleron, Pascal Barbry, David Dombrowicz, Matthias Mack, David Masson, Thomas Bertero, Burkhard Becher, Jesse W. Williams, Konstantin Zaitsev, Yongjian Liu, Rodolphe R. Guinamard, Laurent Yvan-Charvet, Stoyan Ivanov
Summary: The study revealed a large diversity in monocyte and macrophage populations in brown adipose tissue, with monocytes playing a crucial role in tissue expansion and requiring constant replenishment. This highlights the importance of monocyte recruitment for tissue remodeling and expansion in BAT.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Marine M. Leblond, Hana Zdimerova, Emma Desponds, Gregory Verdeil
Summary: Tumor-associated macrophages (TAMs) are abundant in solid tumors and their accumulation promotes tumor progression. Targeting TAMs may improve treatment efficacy and survival outcomes for bladder cancer patients.
Article
Cardiac & Cardiovascular Systems
Bastien Dolfi, Alexandre Gallerand, Arvand Haschemi, Rodolphe R. Guinamard, Stoyan Ivanov
Summary: This review focuses on the diversity of plaque resident myeloid cells and their metabolic demands, discussing how their intraplaque localization may influence their functions and contribution to disease development. Defining the metabolic configuration of these cells based on their topologic distribution could provide insights into key questions regarding their roles in disease progression.
Article
Biochemistry & Molecular Biology
Sara Trabanelli, Giuseppe Ercolano, Tania Wyss, Alejandra Gomez-Cadena, Maryline Falquet, Daniela Cropp, Claire Imbratta, Marine M. Leblond, Valentina Salvestrini, Antonio Curti, Olivier Adotevi, Camilla Jandus, Gregory Verdeil
Summary: The transcription factor c-Maf is found to be indispensable for optimal type 2 cytokine production and proper memory-like responses in group-2 innate lymphoid cells (ILC2s).
Article
Immunology
Laure Tille, Daniela Cropp, Melanie Charmoy, Patrick Reichenbach, Massimo Andreatta, Tania Wyss, Gabrielle Bodley, Isaac Crespo, Sina Nassiri, Joao Lourenco, Marine M. Leblond, Cristina Lopez-Rodriguez, Daniel E. Speiser, George Coukos, Melita Irving, Santiago J. Carmona, Werner Held, Gregory Verdeil
Summary: Persistent exposure to antigen during chronic infection or cancer can cause dysfunction in T cells. NFAT5, a type of transcription factor, plays a crucial role in tumor-induced CD8(+) T cell exhaustion but not in exhaustion caused by chronic infection. Overexpression of NFAT5 weakens tumor control, while deletion of NFAT5 improves tumor control and promotes the accumulation of exhausted CD8(+) T cells.
Article
Endocrinology & Metabolism
Johanna Merlin, Stoyan Ivanov, Adelie Dumont, Alexey Sergushichev, Julie Gall, Marion Stunault, Marion Ayrault, Nathalie Vaillant, Alexia Castiglione, Amanda Swain, Francois Orange, Alexandre Gallerand, Thierry Berton, Jean-Charles Martin, Stefania Carobbio, Justine Masson, Inna Gaisler-Salomon, Pierre Maechler, Stephen Rayport, Judith C. Sluimer, Erik A. L. Biessen, Rodolphe R. Guinamard, Emmanuel L. Gautier, Edward B. Thorp, Maxim N. Artyomov, Laurent Yvan-Charvet
Summary: Non-canonical glutamine metabolism is essential for efficient clearance of dying cells by macrophages in atherosclerotic plaques. This process involves redox buffering, energy production, and cytoskeletal rearrangements. High expression of glutaminase-1 is associated with atherosclerotic plaque necrosis in cardiovascular disease patients.
Article
Oncology
Kaat de Jonge, Laure Tille, Joao Lourenco, Helene Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Gregory Verdeil, Petra Baumgaertner, Daniel E. Speiser
Summary: The role of B cells in solid tumor patients is insufficiently understood. Research suggests that B cells may promote tumor growth by producing inflammatory cytokines, affecting treatment response and overall survival. Different subsets of B cells may have varying impacts on tumor development, necessitating further study for identification and characterization.
Article
Oncology
Nicolas Gestermann, Damien Saugy, Christophe Martignier, Laure Tille, Silvia A. Fuertes Marraco, Markus Zettl, Inigo Tirapu, Daniel E. Speiser, Gregory Verdeil