The biological and therapeutic relevance of mRNA translation in cancer

The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation

(2015) Songqing Fan et al.   NEOPLASIA

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia

(2010) Rong Chen et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Grp78 promotes the invasion of hepatocellular carcinoma

(2010) Rongjian Su et al.   BMC CANCER

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival

(2010) Bryan C. Barnhart et al.   CANCER BIOLOGY & THERAPY

Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity

(2010) Abujiang Pataer et al.   CANCER BIOLOGY & THERAPY

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

(2010) Qing-Bai She et al.   CANCER CELL

The chemotherapeutic agent bortezomib induces the formation of stress granules

(2010) Marie-Josée Fournier et al.   Cancer Cell International

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

(2010) Lorenzo Montanaro et al.   CANCER RESEARCH

MNK, EIF4E and targeting translation for therapy

(2010) Ricardo L.A. Silva et al.   CELL CYCLE

Untangling the unfolded protein response

(2010) Emma L. Davenport et al.   CELL CYCLE

Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

(2010) Andrew Y. Choo et al.   CELL CYCLE

Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma

(2010) David M. Lucas et al.   CURRENT DRUG TARGETS

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Decreased GRP78 Protein Expression is a Potential Prognostic Marker of Oral Squamous Cell Carcinoma in Taiwan

(2010) Tze-Ta Huang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?

(2010) Katherine L. B. Borden et al.   LEUKEMIA & LYMPHOMA

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

(2010) Martin D. Jennings et al.   NATURE

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Estrogen-induced activation of extracellular signal-regulated kinase signaling triggers dendritic resident mRNA translation

(2010) S.N. Sarkar et al.   NEUROSCIENCE

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1

(2010) L C Cobbold et al.   ONCOGENE

FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma

(2010) V. E. Kwitkowski et al.   ONCOLOGIST

Efficient Synthetic Approach to Potent Antiproliferative Agent Hippuristanol via Hg(II)-Catalyzed Spiroketalization

(2010) Kontham Ravindar et al.   ORGANIC LETTERS

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism

(2010) Ying Wang et al.   PLoS One

Diverse poly(A) binding proteins mediate internal translational initiation by a plant viral IRES

(2010) Liraz Marom et al.   RNA Biology

Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78

(2009) U. K. Misra et al.   APOPTOSIS

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

(2009) David M. Lucas et al.   BLOOD

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF- B-Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN

(2009) S. Park et al.   CANCER RESEARCH

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

(2009) J. R. Graff et al.   CANCER RESEARCH

Expeditious Synthesis of Hippuristanol and Congeners with Potent Antiproliferative Activities

(2009) Wei Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Phosphorylated 4E-BP1 Is Associated with Poor Survival in Melanoma

(2009) K. E. O'Reilly et al.   CLINICAL CANCER RESEARCH

Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid

(2009) Ruth Chu et al.   INTERNATIONAL JOURNAL OF CANCER

eIF4E: New Family Members, New Binding Partners, New Roles

(2009) Robert E. Rhoads   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase III Study to Evaluate Temsirolimus Compared With Investigator's Choice Therapy for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

(2009) Georg Hess et al.   JOURNAL OF CLINICAL ONCOLOGY

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

(2009) Regina Cencic et al.   LEUKEMIA RESEARCH

Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma

(2009) Rui Wang et al.   LUNG CANCER

Canonical Initiation Factor Requirements of the Myc Family of Internal Ribosome Entry Segments

(2009) K. A. Spriggs et al.   MOLECULAR AND CELLULAR BIOLOGY

Uncoupling Stress Granule Assembly and Translation Initiation Inhibition

(2009) Sophie Mokas et al.   MOLECULAR BIOLOGY OF THE CELL

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

(2009) G. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides

(2009) R. Juliano et al.   MOLECULAR PHARMACEUTICS

eIF2α kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

(2009) An N. Dang Do et al.   PHYSIOLOGICAL GENOMICS

Altering Chemosensitivity by Modulating Translation Elongation

(2009) Francis Robert et al.   PLoS One

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

How do microRNAs regulate gene expression?

(2008) Ian G. Cannell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

(2008) Yoshiyuki Yoneda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells

(2008) Ellen Jorgensen et al.   BMC CANCER

Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin

(2008) Junichi Matsuo et al.   CANCER SCIENCE

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Phase II Study of Erlotinib in Recurrent or Metastatic Endometrial Cancer: NCIC IND-148

(2008) Amit M. Oza et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance

(2008) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Selective Pharmacological Targeting of a DEAD Box RNA Helicase

(2008) Lisa Lindqvist et al.   PLoS One

Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung

(2007) Steven G. Kelsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Re-programming of translation following cell stress allows IRES-mediated translation to predominate

(2007) Keith A. Spriggs et al.   BIOLOGY OF THE CELL