Wind of Change Challenges Toxicological Regulators

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Drug-mediated toxicity: illuminating the ‘bad’ in the test tube by means of cellular assays?

(2012) Tewes Tralau et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Present state and future perspectives of using pluripotent stem cells in toxicology research

(2011) Anna M. Wobus et al.   ARCHIVES OF TOXICOLOGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

Alternatives to animal testing: current status and future perspectives

(2011) Manfred Liebsch et al.   ARCHIVES OF TOXICOLOGY

Three-Dimensional Cell Cultures in Toxicology

(2011) Francesco Pampaloni et al.   Biotechnology & Genetic Engineering Reviews

Comparative Analysis of Predictive Models for Nongenotoxic Hepatocarcinogenicity Using Both Toxicogenomics and Quantitative Structure–Activity Relationships

(2011) Zhichao Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol

(2011) Yu-Fan Chen et al.   HEPATOLOGY

Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction

(2011) Shibashish Giri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

(2011) Kazuo Takayama et al.   MOLECULAR THERAPY

Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1

(2011) Robert Landsiedel et al.   Nature Protocols

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

(2011) Kelly J. Chandler et al.   PLoS One

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

(2011) Reha Yildirimman et al.   TOXICOLOGICAL SCIENCES

Development and Evaluation of a Genomic Signature for the Prediction and Mechanistic Assessment of Nongenotoxic Hepatocarcinogens in the Rat

(2011) Mark R. Fielden et al.   TOXICOLOGICAL SCIENCES

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

Role of stem-cell-derived hepatic endoderm in human drug discovery

(2010) Claire N. Medine et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Programming embryonic stem cells to neuronal subtypes

(2010) Mirza Peljto et al.   CURRENT OPINION IN NEUROBIOLOGY

Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure

(2010) Frank Sonntag et al.   JOURNAL OF BIOTECHNOLOGY

Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk

(2010) Robert Kavlock et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing

(2010) Michael Hettwer et al.   REPRODUCTIVE TOXICOLOGY

The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

(2010) Barbara Schenk et al.   REPRODUCTIVE TOXICOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test

(2010) Nicole I. zur Nieden et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

The Potential of Embryonic Stem Cells Combined with -omics Technologies as Model Systems for Toxicology

(2009) J. Winkler et al.   CURRENT MEDICINAL CHEMISTRY

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Integrating (Q)SAR models, expert systems and read-across approaches for the prediction of developmental toxicity

(2009) M. Hewitt et al.   REPRODUCTIVE TOXICOLOGY

Metabolism, variability and risk assessment

(2009) J.L.C.M. Dorne   TOXICOLOGY

A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426

(2008) Susan L. Makris et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A systems biology based integrative framework to enhance the predictivity ofin vitromethods for drug-induced liver injury

(2008) Kalyanasundaram Subramanian et al.   Expert Opinion On Drug Safety

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE