Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart

Association Between Serum Vitamin B12 Levels and the Degree of Steatosis in Patients With Nonalcoholic Fatty Liver Disease

(2016) Mustafa Koplay et al.   JOURNAL OF INVESTIGATIVE MEDICINE

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

(2013) Paula Dominguez-Salas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

(2013) Jordan Gallinetti et al.   BIOCHEMICAL JOURNAL

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase

(2013) Jean-Louis Guéant et al.   BIOCHIMIE

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Myocardium proteome remodelling after nutritional deprivation of methyl donors

(2013) Emilie Martinez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Folate and fetal programming: a play in epigenomics?

(2013) Jean-Louis Guéant et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

(2013) R Ghemrawi et al.   Cell Death & Disease

Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124

(2013) R Kerek et al.   Cell Death & Disease

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation

(2013) Romain Barres et al.   Cell Reports

Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

(2012) Kyojiro Kawakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of nutrition on epigenetic modifications and their implications on health

(2012) Josep C. Jiménez-Chillarón et al.   BIOCHIMIE

Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study

(2012) NE Bergen et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity

(2012) A W Drong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition

(2012) Elena Ivanova et al.   Epigenetics

Honeybees and cell lines as models of DNA methylation and aging in response to diet

(2012) Dianne Ford   EXPERIMENTAL GERONTOLOGY

Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells

(2012) Nassila Akchiche et al.   FASEB JOURNAL

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates

(2012) Melissa A. Suter et al.   FASEB JOURNAL

Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism

(2012) Volodymyr Tryndyak et al.   FASEB JOURNAL

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

(2012) Markus Sällman Almén et al.   GENOMICS

Insulin-Like Growth Factor 1 Alleviates High-Fat Diet–Induced Myocardial Contractile Dysfunction

(2012) Yingmei Zhang et al.   HYPERTENSION

Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation

(2012) R.M. Guéant Rodriguez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver

(2012) Shabnam Pooya et al.   JOURNAL OF HEPATOLOGY

Polymorphisms in 1-Carbon Metabolism, Epigenetics and Folate-Related Pathologies

(2012) Patrick J. Stover   Journal of Nutrigenetics and Nutrigenomics

Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice

(2012) Xuefeng Han et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses

(2012) Hélène Pellanda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

Reversible switching between epigenetic states in honeybee behavioral subcastes

(2012) Brian R Herb et al.   NATURE NEUROSCIENCE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice

(2012) Michelangela Barbieri et al.   PLoS One

Genetic Variant of AMD1 Is Associated with Obesity in Urban Indian Children

(2012) Rubina Tabassum et al.   PLoS One

Fetal programming: Maternal nutrition and role of one-carbon metabolism

(2012) Chittaranjan Sakerlal Yajnik et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Protection of the Heart Against Ischemia/Reperfusion by Silent Information Regulator 1

(2012) Takanobu Yamamoto et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

(2012) Henriette Kirchner et al.   TRENDS IN CELL BIOLOGY

New insights into ER stress-induced insulin resistance

(2012) Mélissa Flamment et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity

(2012) Peter Kuehnen et al.   PLoS Genetics

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

(2011) Benjamin F. Miller et al.   AGING CELL

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Developmental programming and epigenetics

(2011) Anne Gabory et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nutrition, Epigenetics, and Metabolic Syndrome

(2011) Junjun Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Caloric excess or restriction mediated modulation of metabolic enzyme acetylation—proposed effects on cardiac growth and function

(2011) Michael N. Sack   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats

(2011) Samuel P. Hoile et al.   BRITISH JOURNAL OF NUTRITION

Functional Variant in Methionine Synthase Reductase Intron-1 Significantly Increases the Risk of Congenital Heart Disease in the Han Chinese Population

(2011) Jian-Yuan Zhao et al.   CIRCULATION

microRNAs in the Regulation of Adipogenesis and Obesity

(2011) R. A. McGregor et al.   CURRENT MOLECULAR MEDICINE

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss

(2011) Fermin I. Milagro et al.   FASEB JOURNAL

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

(2011) Céline Jousse et al.   FASEB JOURNAL

Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues

(2011) Cristina Parrado-Fernández et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diet-induced Lethality Due to Deletion of theHdac3Gene in Heart and Skeletal Muscle

(2011) Zheng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets

(2011) Jiong Li et al.   JOURNAL OF HEPATOLOGY

Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction

(2011) Natasha H. Banke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Low Maternal Vitamin B-12 Status Is Associated with Offspring Insulin Resistance Regardless of Antenatal Micronutrient Supplementation in Rural Nepal

(2011) Christine P. Stewart et al.   JOURNAL OF NUTRITION

Fattening by deprivation: methyl balance and perinatal cardiomyopathy

(2011) Jacob Joseph   JOURNAL OF PATHOLOGY

Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1

(2011) Maira Moreno Garcia et al.   JOURNAL OF PATHOLOGY

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Maternal Protein Restriction Elevates Cholesterol in Adult Rat Offspring Due to Repressive Changes in Histone Modifications at theCholesterol 7α-HydroxylasePromoter

(2011) Gurjeev Sohi et al.   MOLECULAR ENDOCRINOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Nucleus-specific effects of meal duration on daily profiles of Period1 and Period2 protein expression in rats housed under restricted feeding

(2011) M. Verwey et al.   NEUROSCIENCE

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

The Intensity of IUGR-Induced Transcriptome Deregulations Is Inversely Correlated with the Onset of Organ Function in a Rat Model

(2011) Daniel Vaiman et al.   PLoS One

Early and Late Postnatal Myocardial and Vascular Changes in a Protein Restriction Rat Model of Intrauterine Growth Restriction

(2011) Carlos Menendez-Castro et al.   PLoS One

Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation

(2011) Kevin J. Dudley et al.   PLoS One

Honey Bee PTEN – Description, Developmental Knockdown, and Tissue-Specific Expression of Splice-Variants Correlated with Alternative Social Phenotypes

(2011) Navdeep S. Mutti et al.   PLoS One

Dietary Protein Restriction during F0 Pregnancy in Rats Induces Transgenerational Changes in the Hepatic Transcriptome in Female Offspring

(2011) Samuel P. Hoile et al.   PLoS One

High fat diet induced diabetic cardiomyopathy

(2011) Ellen Dirkx et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Maternal macronutrient and energy intakes in pregnancy and offspring intake at 10 y: exploring parental comparisons and prenatal effects

(2010) Marie-Jo A Brion et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

(2010) Kelly K. Andringa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease

(2010) Graham C. Burdge et al.   Annual Review of Nutrition

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals

(2010) Matthias Blüher   CURRENT OPINION IN LIPIDOLOGY

Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes

(2010) Zivjena Vucetic et al.   ENDOCRINOLOGY

Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life

(2010) Jane L. Tarry-Adkins et al.   FASEB JOURNAL

Characterizing the profile of obese patients who are metabolically healthy

(2010) V Primeau et al.   INTERNATIONAL JOURNAL OF OBESITY

Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents

(2010) Marie-Laure Frelut et al.   International Journal of Pediatric Obesity

Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability

(2010) Mark J. Nijland et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Fathers' nutritional legacy

(2010) Michael K. Skinner   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Acute and long-term nutrient-led modifications of gene expression: Potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function

(2010) Mark J. Holness et al.   NUTRITION

Metabolic Adaptation Follows Contractile Dysfunction in the Heart of Obese Zucker Rats Fed a High-Fat “Western” Diet

(2010) Mathias Burgmaier et al.   Obesity

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

(2010) E H Jeninga et al.   ONCOGENE

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus

(2010) Ricardo Orozco-Solís et al.   PLoS One

Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring

(2010) J. L. Slater-Jefferies et al.   Journal of Developmental Origins of Health and Disease

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

(2010) Robert A. Waterland et al.   PLoS Genetics

Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

(2009) Luigi Bouchard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Methyl Donor Deficiency Affects Fetal Programming of Gastric Ghrelin Cell Organization and Function in the Rat

(2009) Carine Bossenmeyer-Pourié et al.   AMERICAN JOURNAL OF PATHOLOGY

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring

(2009) Junlong Zhang et al.   BMC GENOMICS

Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype

(2009) Sarah J. Lewis et al.   BRITISH JOURNAL OF NUTRITION

Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study

(2009) Sarah Timmermans et al.   BRITISH JOURNAL OF NUTRITION

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Nutritional Programming Affects Hypothalamic Organization and Early Response to Leptin

(2009) Bérengère Coupé et al.   ENDOCRINOLOGY

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

(2009) Hieronim Jakubowski et al.   FASEB JOURNAL

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

(2009) Elmar W. Tobi et al.   HUMAN MOLECULAR GENETICS

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

(2009) Igor P. Pogribny et al.   JOURNAL OF HEPATOLOGY

Folic Acid Supplementation during the Juvenile-Pubertal Period in Rats Modifies the Phenotype and Epigenotype Induced by Prenatal Nutrition

(2009) Graham C. Burdge et al.   JOURNAL OF NUTRITION

High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats

(2009) F. I. Milagro et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

(2009) Andreas Plagemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

Individuality and epigenetics in obesity

(2009) J. Campión et al.   Obesity Reviews

Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation

(2009) Jiujiu Yu et al.   PHARMACOLOGICAL RESEARCH

Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE

(2009) S.-f. Battaglia-Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Adenosyl-L-Methionine Co-administration Prevents the Ethanol-Elicited Dissociation of Hepatic Mitochondrial Ribosomes in Male Rats

(2008) Peter Sykora et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Methionine Metabolism and Liver Disease

(2008) José M. Mato et al.   Annual Review of Nutrition

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

(2008) Karen A. Lillycrop et al.   BRITISH JOURNAL OF NUTRITION

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Maternal and Postnatal Overnutrition Differentially Impact Appetite Regulators and Fuel Metabolism

(2008) Hui Chen et al.   ENDOCRINOLOGY

The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.

(2008) Sarah J Lewis et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Perinatal protein restriction reduces the inhibitory action of serotonin on food intake

(2008) Sandra Lopes de Souza et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

(2008) Nupur Raychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome

(2008) Kjersti M Aagaard-Tillery et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity

(2008) G.-Q. Chang et al.   JOURNAL OF NEUROSCIENCE

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet

(2008) G. J. Howie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prolonged Caloric Restriction in Obese Patients With Type 2 Diabetes Mellitus Decreases Myocardial Triglyceride Content and Improves Myocardial Function

(2008) Sebastiaan Hammer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1 

(2008) A. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

(2008) R. Kucharski et al.   SCIENCE