Article
Medicine, Research & Experimental
Nobuharu Tamaki, Noora Ahlholm, Panu K. Luukkonen, Kimmo Porthan, Suzanne R. Sharpton, Veeral Ajmera, Yuko Kono, Shravan Dave, Aijaz Ahmed, Vinay Sundaram, Michael J. Wilkinson, Heather Patton, Hersh Gupta, Vanessa Cervantes, Christie Hernandez, Scarlett J. Lopez, Ria Loomba, Amanda Baumgartner, Lisa Richards, Perttu E. T. Arkkila, Katriina Nemes, Helena Isoniemi, Hannele Yki-Jaervinen, Rohit Loomba
Summary: First-degree relatives of patients with NAFLD with advanced fibrosis have a significantly increased risk of advanced fibrosis, indicating the need for routine screening.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Nam Ju Heo, Hyo Eun Park, Ji Won Yoon, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Jeong Yoon Yim, Goh Eun Chung
Summary: The study revealed that higher serum vitamin D levels were associated with a decreased risk of CAP-defined NAFLD compared to lower levels, suggesting a potential protective role of vitamin D against NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Sang Bong Ahn
Summary: Nonalcoholic fatty liver disease (NAFLD) affects a significant portion of the global population and includes various stages such as nonalcoholic fatty liver, nonalcoholic steatohepatitis (NASH), and cirrhosis. Early detection and diagnosis of liver steatosis are important in preventing the progression of severe liver diseases. This report provides an overview of currently known serum biomarkers for liver steatosis and offers guidance on their practical application in clinical settings.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Dan L. Dumitrascu
Summary: After analyzing the role of visfatin in nonalcoholic fatty liver disease, it was found that visfatin levels are not associated with NAFLD, presence or severity of hepatic steatosis, liver fibrosis, lobar inflammation, NASH, and gender.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
Summary: Serum ferritin and uric acid levels are closely associated with the risk of NAFLD. The AUC value of serum ferritin and uric acid in the NAFLD group was 0.771.
Article
Gastroenterology & Hepatology
Shuai Yuan, Susanna C. Larsson
Summary: This study conducted a bidirectional Mendelian randomization to explore the association between serum 25-hydroxyvitamin D and NAFLD. It found that increased vitamin D levels may play a role in preventing NAFLD in European populations.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Nutrition & Dietetics
Kok-Yong Chin, Sophia Ogechi Ekeuku, Deborah Chia Hsin Chew, Anne Trias
Summary: The burden of NAFLD is growing, but effective pharmacological treatments are still lacking. Alpha-tocopherol, a vitamin E isomer, is currently recommended for NAFLD patients. Another vitamin E member called tocotrienol (T3) has shown potential in managing NAFLD due to its anti-inflammatory and antioxidant properties. This systematic review found that T3 supplementation improved NAFLD outcomes in both clinical and preclinical studies. However, more comprehensive studies are needed to validate its effectiveness.
Article
Biochemistry & Molecular Biology
Woori Chae, Kyung Jae Lee, Ki Young Huh, Jin Soo Moon, Jae Sung Ko, Joo-Youn Cho
Summary: This study aimed to evaluate the metabolome profile and metabolic pathway changes associated with pediatric NAFLD, successfully developing machine learning-based diagnostic models with excellent performance. Metabolome changes in pediatric NAFLD patients' plasma are associated with disease pathophysiology and can be used for less invasive diagnosis.
Article
Medicine, General & Internal
Eun-Ju Cho, Gu-Cheol Jung, Min-Sun Kwak, Jong-In Yang, Jeong-Yoon Yim, Su-Jong Yu, Goh-Eun Chung
Summary: This study validated the effectiveness of FLI in predicting NAFLD and found the optimal FLI cutoff value for the entire Korean population to be 29, with sex-specific values of 31 for males and 18 for females. These findings may be helpful for the accurate diagnosis of NAFLD.
Review
Biochemistry & Molecular Biology
Guilherme da Silva Ferreira, Sergio Catanozi, Marisa Passarelli
Summary: Restriction in sodium intake is important for reducing cardiovascular diseases, but the influence on the development of nonalcoholic fatty liver disease (NAFLD) has been less studied. This systematic review compiled evidence from human and animal studies to examine the influence of dietary sodium intake patterns on NAFLD markers;
Article
Gastroenterology & Hepatology
Donghee Kim, Richie Manikat, George Cholankeril, Aijaz Ahmed
Summary: In men, low total testosterone levels and increasing T/E2 ratio were associated with higher odds of NAFLD, while decreasing SHBG levels were independently associated with increased risk of NAFLD in both men and postmenopausal women. Increasing FAI was also independently associated with NAFLD, with a dose-dependent inverse association between T/E2 ratio and NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jieun Chung, Hee-Sun Park, Young-Jun Kim, Mi-Hye Yu, Sungeun Park, Sung-Il Jung
Summary: This study investigated the association of hepatic steatosis determined by non-enhanced CT criteria with clinical parameters in a screening population. The presence of hepatic steatosis was significantly associated with levels of serum fasting glucose and triglycerides, the ALT/AST ratio, BMI, and HSI values. Logistic regression analysis revealed significant associations between serum fasting glucose level and HSI with hepatic steatosis using criterion (a), and between ALT/AST ratio and HSI with hepatic steatosis using criteria (b) and (c). Hepatic steatosis on non-enhanced CT should be considered to indicate possible clinical profile abnormalities regarding metabolic syndrome.
Article
Endocrinology & Metabolism
Shiwei Li, Yuhong Fu, Yue Liu, Xinxin Zhang, Haijun Li, Lei Tian, Lin Zhuo, Ming Liu, Jingqiu Cui
Summary: This study used Mendelian randomization analysis to investigate the causal relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD). The results showed that NAFLD is associated with elevated SUA levels, but elevated SUA levels do not have a causal association with the risk of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
