Article
Cell Biology
Liyuan Wu, Le Yin, Linxiang Ma, Jiarui Yang, Feiya Yang, Baofa Sun, Xing Nianzeng
Summary: High expression of RRM2 is associated with tumor prognosis and immunotherapy. The study reveals that high levels of RRM2 are associated with worse patient survival and immunotherapy effects through pan-cancer analysis and risk score analysis.
Article
Cell Biology
Yang Gao, Bin Chen, Ruru Wang, An Xu, Lijun Wu, Huayi Lu, Guoping Zhao
Summary: Targeting RRM1 promotes ferroptosis and affects the sensitivity of cancer cells to radiation and chemotherapy. RRM1 disrupts the activity and expression of antioxidant enzyme GPX4, leading to increased accumulation of reactive oxygen species and lipid peroxidation. Furthermore, targeting RRM1 also increases radiation-induced DNA damage and apoptotic signaling, causing crosstalk between ferroptosis and apoptosis.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Qian Liu, Lijuan Guo, Hongyan Qi, Meng Lou, Rui Wang, Boning Hai, Kailun Xu, Lijun Zhu, Yongfeng Ding, Chen Li, Lingdan Xie, Jing Shen, Xueping Xiang, Jimin Shao
Summary: The study revealed a significant correlation between the expression of MYBL2 and RRM2 in colorectal cancer (CRC), with MYBL2 playing a crucial role in CRC cell proliferation, DNA synthesis, and cell cycle progression in an RRM2-dependent manner. MYBL2 was found to directly bind to the promoter of RRM2 gene and promote its transcription during S-phase in collaboration with TAF15 and MuvB components. Combined suppression of MYBL2 and WEE1 was shown to synergistically inhibit CRC growth with low systemic toxicity in vivo, suggesting a potential novel approach for CRC treatment targeting both transcription and degradation machinery of RRM2.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Junlei Han, Jianping Hu, Fang Sun, Hongzhi Bian, Bingxiang Tang, Xiang Fang
Summary: miR-20a suppresses NSCLC growth by inhibiting the RRM2-mediated PI3K/Akt signaling pathway, serving as a potential tumor suppressor and molecular target for NSCLC treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, Johnson A. Joseph, Tyler D. Ball, Mikaela M. Bassil, Ahyun Son, Chen Zhang, Aurelie Ledreux, Scott Horowitz, Yan Qin, Daniel Paredes, Sunil Kumar
Summary: Inhibiting the self-assembly of alpha-synuclein into amyloid structures is a potential therapeutic strategy for Parkinson's disease. This study identifies the essential domains/sequences involved in alpha-synuclein aggregation and tests the effectiveness of foldamer-based antagonists as potential therapeutic targets. The findings provide valuable insights into alpha-synuclein aggregation and have significant implications for the development of effective treatments for Parkinson's disease.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Yaqiong Zhan, Lushun Jiang, Xuehang Jin, Shuaibing Ying, Zhe Wu, Li Wang, Wei Yu, Jiepeng Tong, Li Zhang, Yan Lou, Yunqing Qiu
Summary: RRM2, the small subunit of ribonucleotide reductase, is commonly overexpressed in chemo-resistant cancer cells, mediating resistance to many chemotherapeutic drugs. Inhibition of RRM2 could enhance the anticancer activity of chemotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Justin L. Lee, Victoria F. Oswald, Saborni Biswas, Ethan A. Hill, Joseph W. Ziller, Michael P. Hendrich, A. S. Borovik
Summary: The study introduced a new series of bimetallic complexes with [Fe-III-(mu-OH)-M-II] cores using a stepwise synthetic approach. Characterization through various methods revealed that these complexes displayed significantly lower reduction potentials, paving the way for future studies on high valent bimetallic complexes in this scaffold.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Ami Maruyama, Yuzo Sato, Joji Nakayama, Junko Murai, Takamasa Ishikawa, Tomoyoshi Soga, Hideki Makinoshima
Summary: This study demonstrates that RRM1 is essential for the growth of small-cell lung carcinoma cells, with its deletion inducing DNA damage response and reducing the number of cells in S phase cell cycle arrest. Additionally, RRM1 deletion causes overall changes in the metabolic profile of SCLC cells, revealing a potential link between tumor growth and the regulation of deoxyribonucleotide metabolism in SCLC.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Glendin Swart, Eleanor Fourie, Jannie C. Swarts
Summary: In this study, a series of phthalocyanine compounds with different functional groups were synthesized, and their spectroscopic and electrochemical properties were investigated.
INORGANIC CHEMISTRY
(2022)
Article
Oncology
Zhongqiang Qin, Bo Xie, Jingyu Qian, Xiang Ma, Lan Zhang, Jianzhu Wei, Zhaoying Wang, Longfei Fan, Ziyi Zhu, Zhen Qian, Hongxiang Yin, Fangquan Zhu, Yulin Tan
Summary: The study evaluated the importance of ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma (HCC) using the Cancer Genome Atlas (TCGA) database. The results showed that RRM2 overexpression was associated with worse prognosis and immune infiltrates in HCC, suggesting that RRM2 may serve as a significant molecular biomarker for HCC diagnosis and prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chihong Song, Tadashi Satoh, Taichiro Sekiguchi, Koichi Kato, Kazuyoshi Murata
Summary: The 20S proteasome is composed of layered alpha and beta heptameric rings, with the alpha 7 subunit self-assembling into a homo-tetradecamer in solution. The structure of the alpha 7 double ring fluctuates considerably in solution, with the potential for insertion of homologous alpha subunits and conversion to hetero-heptameric alpha rings in the 20S proteasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bangjie Chen, Tao Jin, Ziyue Fu, Haiwen Li, Junfa Yang, Yucheng Liu, Yanxun Han, Xinyi Wang, Zhengwei Wu, Tao Xu
Summary: Non-thermal plasma (NTP) enhances the anticancer effects of melatonin (MEL) in hepatocellular carcinoma (HCC) cells by promoting apoptosis, delaying cell cycle progression, and inhibiting cell invasion and migration. This mechanism is associated with the regulation of intracellular reactive oxygen species levels and ribonucleotide reductase regulatory subunit M2 expression. The findings highlight the pharmacological role of MEL and the adjuvant value of NTP in the combination therapy for HCC, with important implications for the development of new approaches for treatment.
Article
Oncology
Man-Hon Chung, Rehanguli Aimaier, Qingxiong Yu, Haibo Li, Yuehua Li, Chengjiang Wei, Yihui Gu, Wei Wang, Zizhen Guo, Manmei Long, Qingfeng Li, Zhichao Wang
Summary: RRM2 expression is significantly elevated in NF1-associated MPNST and high RRM2 expression correlates with poorer outcomes. Inhibition of RRM2 can suppress NF1-associated MPNST cell proliferation and promote apoptosis and S-phase arrest. Therefore, inhibiting RRM2 may be an effective strategy for treating NF1-associated MPNST.
Review
Genetics & Heredity
Jeannette Fuchs, Anais Cheblal, Susan M. Gasser
Summary: Recent studies have highlighted the crucial role of DNA Polymerase 5 (DNA Pol 5) in replication forks, especially under stress conditions. Mutations affecting POLD1, amplifications of POLD2 and POLD3, and compromising the noncatalytic subunits of DNA Pol 5 are all closely related to cancer development and may open up avenues for novel therapies addressing replication stress.
TRENDS IN GENETICS
(2021)
Article
Gastroenterology & Hepatology
Jinlan Shan, Zhen Wang, Qiuping Mo, Jingpei Long, Yangfan Fan, Lu Cheng, Tao Zhang, Xiyong Liu, Xiaochen Wang
Summary: This study found a correlation between high RRM2 expression and poor prognosis in pancreatic cancer patients, and RRM2 inhibition resulted in cell cycle arrest and/or apoptosis. These findings are expected to provide a new theoretical basis for pancreatic cancer treatment.
Article
Chemistry, Medicinal
Marcus J. C. Long, Ann P. Lawson, Rick Baggio, Yu Qian, Lior Rozhansky, Domenico Fasci, Farid El Oualid, Eranthie Weerapana, Lizbeth Hedstrom
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Dziyana Hnedzko, Bo Kyoung Kim, Yimon Aye
Review
Chemistry, Multidisciplinary
Marcus J. C. Long, Xuyu Liu, Yimon Aye
FRONTIERS IN CHEMISTRY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Jesse R. Poganik, Marcus J. C. Long, Yimon Aye
TRENDS IN BIOCHEMICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Lingxi Wang, Yimon Aye
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Alexandra Van Hall-Beauvais, Yimon Aye
CURRENT OPINION IN CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jesse R. Poganik, Alexandra K. Van Hall-Beauvais, Marcus J. C. Long, Michael T. Disare, Yi Zhao, Yimon Aye
HELVETICA CHIMICA ACTA
(2020)
Article
Chemistry, Multidisciplinary
Xuyu Liu, Marcus J. C. Long, Benjamin D. Hopkins, Chaosheng Luo, Lingxi Wang, Yimon Aye
ACS CENTRAL SCIENCE
(2020)
Review
Chemistry, Multidisciplinary
Marcus J. C. Long, Chloe Rogg, Yimon Aye
Summary: The article provides a personal account of the innovation and design principles behind REX technologies, which aim to interrogate precision electrophile signaling in cells and organisms. By developing methods like T-REX and G-REX, the researchers have been able to gain new insights into target engagement and design of covalent medicines.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yi Zhao, Pierre A. Miranda Herrera, Dalu Chang, Romain Hamelin, Marcus J. C. Long, Yimon Aye
Summary: Enzyme-assisted posttranslational modifications (PTMs) play a major role in signaling across cellular compartments. However, the impact of nonenzymatic PTMs on cross-compartment signaling is not well understood. This study establishes a quantitative platform to assess the responsivity of compartmentalized subproteomes to nonenzymatic PTMs, revealing that a significant number of protein sensors respond in compartments of nonprimary origin or where their canonical activity is inoperative.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jesse R. Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Sruthi Raja, Marcus J. C. Long, Yimon Aye
Summary: The study investigates the mechanism of action of dimethyl fumarate on innate immune cell toxicity, revealing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis. Despite the importance of reactive electrophilic drugs, deconvolution of their principal targets remains difficult due to lack of genetic tractability and interference by non-specific compounds during validation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Phillippe Ly, Yimon Aye
Summary: Covalent drugs have re-emerged as a promising approach in drug discovery and design due to their ability to prolong target engagement and target shallower binding sites. Development of covalent drugs involves frameworks like identifying electrophile-sensing residues and studying innate signaling by endogenous molecules to predict drug mechanism and behavior.
RSC MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Marcus J. C. Long, Kuan-Ting Huang, Yimon Aye
Summary: This tutorial review compares and contrasts the chemical mechanisms of electrophile/oxidant sensing and the molecular mechanisms of signal propagation. It critically analyzes biological systems where these pathways are believed to be present and discusses the implications of the data. Finally, it explores the applications of this knowledge in disease treatment and drug development.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Marcus J. C. Long, Yi Zhao, Yimon Aye
RSC CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Marcus J. C. Long, Yi Zhao, Yimon Aye
CELL CHEMICAL BIOLOGY
(2020)
