Journal
CANCER CELL
Volume 22, Issue 1, Pages 3-4Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2012.06.010
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Funding
- NICHD NIH HHS [R01 HD059120] Funding Source: Medline
- NIDDK NIH HHS [R01 DK058144] Funding Source: Medline
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In this issue of Cancer Cell, Hu et al. report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged DNA and produce nucleotides necessary for DNA repair while suppressing uracil incorporation. TMPK inhibition disrupts this balance and selectively sensitizes cancer cells to low-dose chemotherapy.
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