DNA damage associated with mitosis and cytokinesis failure

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Cell division control by the Chromosomal Passenger Complex

(2012) Maike S. van der Waal et al.   EXPERIMENTAL CELL RESEARCH

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells

(2012) Judit Pampalona et al.   PLoS Genetics

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

DNA Damage Response Is Suppressed by the High Cyclin-dependent Kinase 1 Activity in Mitotic Mammalian Cells

(2011) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit

(2011) F. G. Westhorpe et al.   JOURNAL OF CELL SCIENCE

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints

(2010) Conly L. Rieder   CHROMOSOME RESEARCH

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Mechanisms of aneuploidy

(2010) Duane A Compton   CURRENT OPINION IN CELL BIOLOGY

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

p53 suppresses structural chromosome instability after mitotic arrest in human cells

(2010) W B Dalton et al.   ONCOGENE

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

(2010) Marcel A. T. M. van Vugt et al.   PLOS BIOLOGY

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Sister chromatid tension and the spindle assembly checkpoint

(2009) Luigi Nezi et al.   CURRENT OPINION IN CELL BIOLOGY

DNA Damage Checkpoint Maintains Cdh1 in an Active State to Inhibit Anaphase Progression

(2009) Tao Zhang et al.   DEVELOPMENTAL CELL

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

(2009) W Brian Dalton et al.   Future Oncology

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

(2009) Y.-F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Clearing the way for mitosis: is cohesin a target?

(2009) Mitsuhiro Yanagida   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

(2009) D. K. Slonim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Cell Type Variation in Responses to Antimitotic Drugs that Target Microtubules and Kinesin-5

(2008) J. Shi et al.   CANCER RESEARCH

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development

(2008) D. O. Cowley et al.   MOLECULAR AND CELLULAR BIOLOGY

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

(2008) Brian G. Fuller et al.   NATURE

Extra centrosomes and/or chromosomes prolong mitosis in human cells

(2008) Zhenye Yang et al.   NATURE CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells

(2008) Daniela A. Brito et al.   CELL MOTILITY AND THE CYTOSKELETON

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY