Hypoxia Differentially Modulates the Genomic Stability of Clinical-Grade ADSCs and BM-MSCs in Long-Term Culture

ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism

(2015) N Bigot et al.   Cell Death & Disease

Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia

(2014) Alessandra Bura et al.   CYTOTHERAPY

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

(2014) A. B. Perez-Oliva et al.   EMBO JOURNAL

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

(2014) Ying Wang et al.   NATURE IMMUNOLOGY

Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells

(2014) Tara Sugrue et al.   STEM CELLS

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

(2013) Nidhi Sharma et al.   CELL CYCLE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accumulation of DNA Damage-Induced Chromatin Alterations in Tissue-Specific Stem Cells: The Driving Force of Aging?

(2013) Nadine Schuler et al.   PLoS One

Differentiation-Related Response to DNA Breaks in Human Mesenchymal Stem Cells

(2013) Lisa Oliver et al.   STEM CELLS

Clinical-Grade Mesenchymal Stromal Cells Produced Under Various Good Manufacturing Practice Processes Differ in Their Immunomodulatory Properties: Standardization of Immune Quality Controls

(2013) Cedric Menard et al.   STEM CELLS AND DEVELOPMENT

53BP1: pro choice in DNA repair

(2013) Michal Zimmermann et al.   TRENDS IN CELL BIOLOGY

Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

(2013) J C Estrada et al.   Cell Death & Disease

Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation

(2013) Y Wang et al.   Cell Death & Disease

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks

(2012) Shane M. Harding et al.   CELL CYCLE

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability

(2012) R. Kumareswaran et al.   JOURNAL OF CELL SCIENCE

Mesenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations

(2012) Young Min Cho et al.   PLoS One

Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells

(2012) Pedro H. Oliveira et al.   Stem Cell Research

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia

(2011) F. Bouquet et al.   JOURNAL OF CELL SCIENCE

ATM-dependent phosphorylation of 53BP1 in response to genomic stress in oxic and hypoxic cells

(2011) Shane M. Harding et al.   RADIOTHERAPY AND ONCOLOGY

Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells

(2010) Simi M. Chacko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

(2010) C.-C. Tsai et al.   BLOOD

Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter

(2010) A. Torsvik et al.   CANCER RESEARCH

Good Manufacturing Practices Production of Mesenchymal Stem/Stromal Cells

(2010) Luc Sensebé et al.   HUMAN GENE THERAPY

Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase

(2009) Yonghui Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

(2009) K. Tarte et al.   BLOOD

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

Protection of mitochondrial genome integrity: A new stem cell property?

(2009) Malcolm R. Alison et al.   HEPATOLOGY

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells

(2008) Francisco Javier Rodríguez-Jiménez et al.   STEM CELLS