Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

Constant Illumination Induces Alzheimer-Like Damages with Endoplasmic Reticulum Involvement and the Protection of Melatonin

(2017) Zhi-Qun Ling et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS

(2012) Matthis Synofzik et al.   HUMAN MOLECULAR GENETICS

Riluzole

(2012) Alessandra Cifra et al.   NEUROSCIENTIST

Age-related changes in neuroendocrine rhythmic function in the rhesus macaque

(2011) Henryk F. Urbanski et al.   AGE

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder

(2011) Ritsaert Lieverse et al.   ARCHIVES OF GENERAL PSYCHIATRY

Systemic inflammation and delirium: important co-factors in the progression of dementia

(2011) Colm Cunningham   BIOCHEMICAL SOCIETY TRANSACTIONS

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with Intellectual Disability

(2011) Cecile Pagan et al.   BMC Medical Genetics

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

(2011) M. D. Mediavilla et al.   CURRENT MEDICINAL CHEMISTRY

The role of free radical generation in increasing cerebrovascular permeability

(2011) Paul A. Fraser   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin-Dependent Timing of Seasonal Reproduction by the Pars Tuberalis: Pivotal Roles for Long Daylengths and Thyroid Hormones

(2011) Hugues Dardente   JOURNAL OF NEUROENDOCRINOLOGY

Inflammation in the early stages of neurodegenerative pathology

(2011) Preeti J. Khandelwal et al.   JOURNAL OF NEUROIMMUNOLOGY

Hypoxia-Induced Cellular and Vascular Changes in the Nucleus Tractus Solitarius and Ventrolateral Medulla

(2011) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

(2011) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca2+, and lipid insults in NARP cybrids: a potential therapeutic target for melatonin

(2011) Tsung-I Peng et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents down-regulation of astrocytic phosphoprotein PEA-15 in ischemic brain injury

(2011) Phil-Ok Koh   JOURNAL OF PINEAL RESEARCH

Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response

(2011) Shih-Huang Tai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury

(2011) Phil-Ok Koh   JOURNAL OF PINEAL RESEARCH

Melatonin preserves the transient mitochondrial permeability transition for protection during mitochondrial Ca2+ stress in astrocyte

(2011) Mei-Jie Jou   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats

(2011) Ming Che Tsai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor

(2011) Patricia J. Lardone et al.   JOURNAL OF PINEAL RESEARCH

Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night

(2011) David E. Blask et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia

(2011) Ulkan Kilic et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its analogs in insomnia and depression

(2011) Daniel P. Cardinali et al.   JOURNAL OF PINEAL RESEARCH

Sleep–wake disturbances in common neurodegenerative diseases: A closer look at selected aspects of the neural circuitry

(2011) George Zhong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

Nutrition in centenarians

(2011) Dorothy B. Hausman et al.   MATURITAS

Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead

(2011) Leslie J. Blackhall   MUSCLE & NERVE

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

(2011) Yoelvis García-Mesa et al.   NEUROBIOLOGY OF AGING

Melatonin and the Metabolic Syndrome: Physiopathologic and Therapeutical Implications

(2011) Daniel P. Cardinali et al.   NEUROENDOCRINOLOGY

Antioxidant Therapies for Acute Spinal Cord Injury

(2011) Edward D. Hall   Neurotherapeutics

Radio-protective effects of melatonin against irradiation-induced oxidative damage in rat peripheral blood

(2011) Alireza Shirazi et al.   Physica Medica-European Journal of Medical Physics

Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice

(2011) T. A. Bedrosian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson's Disease as a Neuroendocrine Disorder of Circadian Function: Dopamine-Melatonin Imbalance and the Visual System in the Genesis and Progression of the Degenerative Process

(2011) Gregory L. Willis   REVIEWS IN THE NEUROSCIENCES

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Cadmium-Induced Disruption in 24-h Expression of Clock and Redox Enzyme Genes in Rat Medial Basal Hypothalamus: Prevention by Melatonin

(2011) Vanesa Jiménez-Ortega et al.   Frontiers in Neurology

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs

(2010) Venkatramanujam Srinivasan et al.   ADVANCES IN THERAPY

Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats

(2010) Shruti V. Kabadi et al.   Annals of the New York Academy of Sciences

Dietary Antioxidants and Long-term Risk of Dementia

(2010) Elizabeth E. Devore et al.   ARCHIVES OF NEUROLOGY

Melatonin: A pleiotropic molecule regulating inflammation

(2010) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

WITHDRAWN: Neuroendocrine axes function in healthy aging: Evaluation of predictive and manipulable blood serum indexes

(2010) G. Mazzoccoli et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutation screening of melatonin-related genes in patients with autism spectrum disorders

(2010) Lina Jonsson et al.   BMC Medical Genomics

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

(2010) Gilberto Spadoni et al.   CNS Neuroscience & Therapeutics

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

(2010) Daniel P. Cardinali et al.   Current Neuropharmacology

Significance of High Levels of Endogenous Melatonin in Mammalian Cerebrospinal Fluid and in the Central Nervous System

(2010) Dun-Xian Tan et al.   Current Neuropharmacology

Neurotoxins: Free Radical Mechanisms and Melatonin Protection

(2010) Russel J. Reiter et al.   Current Neuropharmacology

Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

(2010) Hongwen He et al.   Current Neuropharmacology

Antiinflammatory Activity of Melatonin in Central Nervous System

(2010) Emanuela Esposito et al.   Current Neuropharmacology

Melatonin Metabolism in the Central Nervous System

(2010) Rudiger Hardeland   Current Neuropharmacology

Investigational melatonin receptor agonists

(2010) Rüdiger Hardeland   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review

(2010) A. de Jonghe et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging

(2010) Nir Barzilai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson’s disease

(2010) Kathleen A. Maguire-Zeiss et al.   JOURNAL OF NEURAL TRANSMISSION

Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder

(2010) Piotr Gałecki et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects periventricular white matter from damage due to hypoxia

(2010) C. Kaur et al.   JOURNAL OF PINEAL RESEARCH

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

(2010) Mariam Chahbouni et al.   JOURNAL OF PINEAL RESEARCH

The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-α toxicity involves membrane melatonin receptors

(2010) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A

(2010) Xifei Yang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders

(2010) SJ Wilson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Major life events and risk of Parkinson's disease

(2010) Naja Hulvej Rod et al.   MOVEMENT DISORDERS

Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury

(2010) S. Nag et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Oscillation development for neurotransmitter-related genes in the mouse striatum

(2010) Yanning Cai et al.   NEUROREPORT

Antioxidant therapies for traumatic brain injury

(2010) Edward D. Hall et al.   Neurotherapeutics

Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report

(2010) R. G. Stevens et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Inner retinal circadian clocks and non-visual photoreceptors: Novel players in the circadian system

(2010) Mario E. Guido et al.   PROGRESS IN NEUROBIOLOGY

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

(2010) Hsiao-Wen Lin et al.   Neuropsychiatric Disease and Treatment

Melatonin Fails to Improve Sleep or Agitation in Double-Blind Randomized Placebo-Controlled Trial of Institutionalized Patients With Alzheimer Disease

(2009) Philip R. Gehrman et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin: Signaling mechanisms of a pleiotropic agent

(2009) Rüdiger Hardeland   BIOFACTORS

Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism

(2009) Qipeng Zhang et al.   BRAIN RESEARCH

Pharmacology of Ramelteon, a Selective MT1/MT2Receptor Agonist: A Novel Therapeutic Drug for Sleep Disorders

(2009) Masaomi Miyamoto   CNS Neuroscience & Therapeutics

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

(2009) Xin Wang   CNS Neuroscience & Therapeutics

Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats*

(2009) Alexander M. Mathes et al.   CRITICAL CARE MEDICINE

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

Impaired Nocturnal Melatonin in Acute Phase of Ischaemic Stroke: Cross-Sectional Matched Case-Control Analysis

(2009) P. A. Atanassova et al.   JOURNAL OF NEUROENDOCRINOLOGY

Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease

(2009) N. Ahmad Aziz et al.   JOURNAL OF NEUROLOGY

The Role of Melatonin in Sleep Disturbances in End-Stage Huntington's Disease

(2009) J. Alders et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model

(2009) Victor Tapias et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents

(2009) Anupom Borah et al.   JOURNAL OF PINEAL RESEARCH

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Brainstem pathology and non-motor symptoms in PD

(2009) Lea Tenenholz Grinberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroprotection by Radical Avoidance: Search for Suitable Agents

(2009) Rüdiger Hardeland   MOLECULES

The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion

(2009) Sujira Mukda et al.   NEUROSCIENCE LETTERS

A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

(2009) Carlos Spuch et al.   NEUROTOXICITY RESEARCH

Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker

(2009) Kun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease

(2009) Tania García et al.   TOXICOLOGY

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease

(2008) Kirstie N. Anderson et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injury

(2008) Seyithan Taysi et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preoperative Anxiolytic Effect of Melatonin and Clonidine on Postoperative Pain and Morphine Consumption in Patients Undergoing Abdominal Hysterectomy: A Double-Blind, Randomized, Placebo-Controlled Study

(2008) Wolnei Caumo et al.   JOURNAL OF PAIN

Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

(2008) Glenna A. Dowling et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

(2008) Shantha MW Rajaratnam et al.   LANCET

Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline

(2008) Antony Payton et al.   NEUROBIOLOGY OF AGING

Melatonin and the Immune System in Aging

(2008) Daniel P. Cardinali et al.   NEUROIMMUNOMODULATION

Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients

(2008) Richard Mahlberg et al.   SLEEP MEDICINE

Neuroendocrine features in extreme longevity

(2007) E. Ferrari et al.   EXPERIMENTAL GERONTOLOGY