PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations

The association between cerebral developmental venous anomaly and concomitant cavernous malformation: an observational study using magnetic resonance imaging

(2014) Guolu Meng et al.   BMC Neurology

Cerebral cavernous malformation proteins at a glance

(2014) Kyle M. Draheim et al.   JOURNAL OF CELL SCIENCE

Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma

(2014) Dejan Jakimovski et al.   JOURNAL OF NEUROSURGERY

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

(2013) Peter H. Sugden et al.   BIOCHEMICAL JOURNAL

Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology

(2013) Oriana S. Fisher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway

(2013) Jonathan N. Rosen et al.   DEVELOPMENTAL BIOLOGY

Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish

(2013) S. Choorapoikayil et al.   Disease Models & Mechanisms

STRIPAK complexes: Structure, biological function, and involvement in human diseases

(2013) Juyeon Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail

(2013) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations

(2013) Chao You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

(2013) Nikolaos Patsoukis et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

(2013) Weizhi Liu et al.   MOLECULAR CELL

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

(2013) Andreas Fischer et al.   TRENDS IN MOLECULAR MEDICINE

Dynamic Regulation of the Cerebral Cavernous Malformation Pathway Controls Vascular Stability and Growth

(2012) Xiangjian Zheng et al.   DEVELOPMENTAL CELL

Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus

(2012) Oriana S. Fisher et al.   FEBS LETTERS

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

(2012) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

Thrombin-triggered angiogenesis in rat brains following experimental intracerebral hemorrhage

(2012) Hua-Jun Zhou et al.   JOURNAL OF NEUROSURGERY

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management

(2011) Remco A Haasdijk et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

(2011) Aubrey C. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Impairment of Tight Junctions and Glucose Transport in Endothelial Cells of Human Cerebral Cavernous Malformations

(2011) Hannah Schneider et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

(2011) Jian J. Liu et al.   MOLECULAR BIOLOGY OF THE CELL

In Vitro Characterization of the Angiogenic Phenotype and Genotype of the Endothelia Derived From Sporadic Cerebral Cavernous Malformations

(2011) Yuan Zhu et al.   NEUROSURGERY

Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway

(2011) J-H Park et al.   ONCOGENE

PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells

(2010) Tao Tian et al.   CARCINOGENESIS

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

(2010) Florence Riant et al.   FEBS Journal

PDCD10/CCM3 Acts Downstream of γ-Protocadherins to Regulate Neuronal Survival

(2010) Chengyi Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Role for PTEN in Regulating Transient Receptor Potential Canonical Channel 6-mediated Ca2+Entry, Endothelial Permeability, and Angiogenesis

(2010) Vidisha Kini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

(2010) M. Fidalgo et al.   JOURNAL OF CELL SCIENCE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential angiogenesis function ofCCM2andCCM3in cerebral cavernous malformations

(2010) Yuan Zhu et al.   Neurosurgical Focus

Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate

(2010) Christopher F. Dibble et al.   PLoS One

Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

(2009) Katrin Voss et al.   HUMAN MUTATION

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

Cavernous malformations: natural history, diagnosis and treatment

(2009) Sachin Batra et al.   Nature Reviews Neurology

CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase

(2009) Liraz Harel et al.   NEURON

Involvement of PTEN Promoter Methylation in Cerebral Cavernous Malformations

(2009) Yuan Zhu et al.   STROKE

Biology of Vascular Malformations of the Brain

(2009) Gabrielle G. Leblanc et al.   STROKE

Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

(2008) Sonja Stahl et al.   HUMAN MUTATION