SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

Structural insights into the activation of MST3 by MO25

(2013) Youcef Mehellou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Q&A: Who needs a centrosome?

(2013) Mónica Bettencourt-Dias   BMC BIOLOGY

Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases

(2013) Meng Zhang et al.   STRUCTURE

Crystallization and preliminary X-ray analysis of the C-terminal domain of CCM2, part of a novel adaptor protein involved in cerebral cavernous malformations

(2012) Xiaoyan Wang et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Crystallization and preliminary crystallographic studies of CCM3 in complex with the C-terminal domain of MST4

(2012) Xueyong Xu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

(2012) Stephen J. Fuller et al.   BIOCHEMICAL JOURNAL

Improvement of 3D protein models using multiple templates guided by single-template model quality assessment

(2012) Maria T. Buenavista et al.   BIOINFORMATICS

Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions

(2012) Adam Frost et al.   CELL

Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle

(2012) A. Nerstedt et al.   DIABETOLOGIA

PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress

(2012) Heyu Zhang   Frontiers in Bioscience-Landmark

STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin

(2012) Barbara Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis

(2012) Toshinori Hyodo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Cerebral Cavernous Malformation 3 (CCM3) Mediates Phosphorylation of the Cytoskeletal Proteins Ezrin/Radixin/Moesin by Mammalian Ste20-4 to Protect Cells from Oxidative Stress

(2012) Miguel Fidalgo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Stk25 as a Genetic Modifier of Tau Phosphorylation in Dab1-Mutant Mice

(2012) Tohru Matsuki et al.   PLoS One

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

The Golgi in Cell Migration: Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis

(2012) Valentina Millarte et al.   TheScientificWorldJOURNAL

Downregulation of SOK1 promotes the migration of MCF-7 cells

(2011) Xu-Dong Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3

(2011) Johnthan Gordon et al.   BMC BIOCHEMISTRY

PAR-1/MARK: a Kinase Essential for Maintaining the Dynamic State of Microtubules

(2011) Kenji Hayashi et al.   CELL STRUCTURE AND FUNCTION

Functional Insights into the Activation Mechanism of Ste20-related Kinases

(2011) Kenneth B. Gagnon et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling

(2011) Amanda L Neisch et al.   CURRENT OPINION IN CELL BIOLOGY

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Role of LKB1-SAD/MARK pathway in neuronal polarization

(2011) Maya Shelly et al.   Developmental Neurobiology

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Mammalian Ste20-like protein kinase 3 plays a role in hypoxia-induced apoptosis of trophoblast cell line 3A-sub-E

(2011) Hung-Yi Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interplay between microtubule dynamics and intracellular organization

(2011) Hélène de Forges et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

(2011) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization

(2011) Derek F. Ceccarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice

(2011) Aubrey C. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative kinome analysis to identify putative colon tumor biomarkers

(2011) Ewa E. Hennig et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke

(2011) L. Zai et al.   JOURNAL OF NEUROSCIENCE

Cerebral cavernous malformations: from genes to proteins to disease

(2011) Daniel D. Cavalcanti et al.   JOURNAL OF NEUROSURGERY

Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability

(2011) H. Cornils et al.   MOLECULAR AND CELLULAR BIOLOGY

The IntFOLD server: an integrated web resource for protein fold recognition, 3D model quality assessment, intrinsic disorder prediction, domain prediction and ligand binding site prediction

(2011) D. B. Roche et al.   NUCLEIC ACIDS RESEARCH

Automated tertiary structure prediction with accurate local model quality assessment using the intfold-ts method

(2011) Liam J. McGuffin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structures of human MST3 kinase in complex with adenine, ADP and Mn2+

(2010) Tzu-Ping Ko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: A novel adaptor protein involved in human cerebral cavernous malformation

(2010) Jingjin Ding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Post-translational myristoylation: Fat matters in cellular life and death

(2010) Dale D.O. Martin et al.   BIOCHIMIE

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

(2010) Jiangning Song et al.   BIOINFORMATICS

Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment

(2010) Tohru Matsuki et al.   CELL

Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype

(2010) Aubrey C. Chan et al.   FEBS Journal

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

(2010) Florence Riant et al.   FEBS Journal

Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction

(2010) Eva Faurobert et al.   FEBS Journal

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

(2010) M. Fidalgo et al.   JOURNAL OF CELL SCIENCE

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging New Roles of GM130, a cis-Golgi Matrix Protein, in Higher Order Cell Functions

(2010) Nobuhiro Nakamura   JOURNAL OF PHARMACOLOGICAL SCIENCES

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of the Melanoma miRNAome by Deep Sequencing

(2010) Mitchell S. Stark et al.   PLoS One

Structural Comparison of Human Mammalian Ste20-Like Kinases

(2010) Christopher J. Record et al.   PLoS One

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

(2010) Susanne Zach et al.   PLoS One

Rapid model quality assessment for protein structure predictions using the comparison of multiple models without structural alignments

(2009) L. J. McGuffin et al.   BIOINFORMATICS

Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation

(2009) Ce‑Belle Chen et al.   BIOSCIENCE REPORTS

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Detection, Validation, and Downstream Analysis of Allelic Variation in Gene Expression

(2009) D. C. Ciobanu et al.   GENETICS

Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

(2009) Katrin Voss et al.   HUMAN MUTATION

Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway

(2009) Chia-Ying Lin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways

(2009) Barbara Lorber et al.   NATURE NEUROSCIENCE

CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase

(2009) Liraz Harel et al.   NEURON

The mammalian family of sterile 20p-like protein kinases

(2009) Eric Delpire   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY

Farp2 and Stk25 Are Candidate Genes for the HDL Cholesterol Locus on Mouse Chromosome 1

(2008) Zhiguang Su et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intrinsic disorder prediction from the analysis of multiple protein fold recognition models

(2008) Liam J. McGuffin   BIOINFORMATICS

Biosignaling of mammalian Ste20-related kinases

(2008) Pin Ling et al.   CELLULAR SIGNALLING

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: Activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors

(2008) Stephen J. Fuller et al.   CELLULAR SIGNALLING

SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death

(2008) Emilio Nogueira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS

Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog

(2007) Dale D. O. Martin et al.   FASEB JOURNAL