Klotho protein in neurodegenerative disorders

Disease-modifying treatments modulate myeloid cells in multiple sclerosis patients

(2017) Gloria Dalla Costa et al.   NEUROLOGICAL SCIENCES

Multiple sclerosis influences on the augmentation of serum Klotho concentration

(2016) Mona Ahmadi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation

(2016) Zhifei Wang et al.   Scientific Reports

The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination

(2015) Ella Zeldich et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing–remitting multiple sclerosis

(2015) Mohammad Sajad Emami Aleagha et al.   JOURNAL OF NEUROIMMUNOLOGY

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

(2015) Anna Massó et al.   PLoS One

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

(2015) Marissa J. Schafer et al.   PLoS One

Immunology of Relapse and Remission in Multiple Sclerosis

(2014) Lawrence Steinman   Annual Review of Immunology

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

(2014) Ella Zeldich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

(2013) C.-D. Chen et al.   JOURNAL OF NEUROSCIENCE

Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

(2013) Xi Kuang et al.   NEUROBIOLOGY OF AGING

Cortical remyelination: A new target for repair therapies in multiple sclerosis

(2012) Ansi Chang et al.   ANNALS OF NEUROLOGY

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

(2012) Carmela R Abraham et al.   Future Medicinal Chemistry

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Exercise-Induced Cognitive Plasticity, Implications for Mild Cognitive Impairment and Alzheimer’s Disease

(2011) Philip P. Foster et al.   Frontiers in Neurology

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Current understanding of klotho

(2008) Yuhong Wang et al.   AGEING RESEARCH REVIEWS

The Klotho gene family as a regulator of endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

(2008) M. Shiozaki et al.   NEUROSCIENCE

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA