A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes withN-Ethylmaleimide or Staurosporine-mediated Activation

Molecular Motions Involved in Na-K-Cl Cotransporter-mediated Ion Transport and Transporter Activation Revealed by Internal Cross-linking between Transmembrane Domains 10 and 11/12

(2014) Michelle Y. Monette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

(2014) Igor Medina et al.   Frontiers in Cellular Neuroscience

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling

(2013) Zesergio Melo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons

(2013) I. Chamma et al.   JOURNAL OF NEUROSCIENCE

Evolution of the Cation Chloride Cotransporter Family: Ancient Origins, Gene Losses, and Subfunctionalization through Duplication

(2013) Anna-Maria Hartmann et al.   MOLECULAR BIOLOGY AND EVOLUTION

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Neto2 is a KCC2 interacting protein required for neuronal Cl−regulation in hippocampal neurons

(2013) Evgueni A. Ivakine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

KCC2 transport activity requires the highly conserved L675 in the C-terminal β1 strand

(2012) Annika Döding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Taurine Inhibits K+-Cl−Cotransporter KCC2 to Regulate Embryonic Cl−Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

(2012) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperpolarizing GABAergic Transmission Requires the KCC2 C-Terminal ISO Domain

(2012) B. A. Acton et al.   JOURNAL OF NEUROSCIENCE

Monitoring the native phosphorylation state of plasma membrane proteins from a single mouse cerebellum

(2012) Jens Schindler et al.   JOURNAL OF NEUROSCIENCE METHODS

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

Differential GABAergic disinhibition during the development of painful peripheral neuropathy

(2011) S.P. Janssen et al.   NEUROSCIENCE

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Phosphoregulation of the Na–K–2Cl and K–Cl cotransporters by the WNK kinases

(2010) Kristopher T. Kahle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

(2010) Zachi Horn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Differences in the Large Extracellular Loop between the K+-Cl−Cotransporters KCC2 and KCC4

(2010) Anna-Maria Hartmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology

(2010) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

(2010) Henry H.C. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

(2010) Pascale Boulenguez et al.   NATURE MEDICINE

PHOSIDA 2011: the posttranslational modification database

(2010) F. Gnad et al.   NUCLEIC ACIDS RESEARCH

CIP1 is an activator of the K+–Cl− cotransporter KCC2

(2009) Meike Wenz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Clustering of Neuronal K+-Cl−Cotransporters in Lipid Rafts by Tyrosine Phosphorylation

(2009) Miho Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1

(2009) Anna-Maria Hartmann et al.   JOURNAL OF NEUROCHEMISTRY

SeaView Version 4: A Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building

(2009) M. Gouy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel di-leucine motif mediating K+/Cl− cotransporter KCC2 constitutive endocytosis

(2008) Beibei Zhao et al.   CELLULAR SIGNALLING

Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons

(2008) A. Shulga et al.   JOURNAL OF NEUROSCIENCE

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE

Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia

(2008) E. Papp et al.   NEUROSCIENCE