The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
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Title
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
Authors
Keywords
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Journal
NATURE REVIEWS MICROBIOLOGY
Volume 11, Issue 7, Pages 482-496
Publisher
Springer Nature
Online
2013-06-10
DOI
10.1038/nrmicro3046
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Note: Only part of the references are listed.- Analysis of hepatitis C virus resistance to silibininin vitroandin vivopoints to a novel mechanism involving nonstructural protein 4B
- (2013) Katharina Esser-Nobis et al. HEPATOLOGY
- Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
- (2013) Ira M. Jacobson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Exploratory Study of Oral Combination Antiviral Therapy for Hepatitis C
- (2013) Fred Poordad et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C
- (2013) Edward J. Gane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection
- (2013) Eric Lawitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
- (2013) J. Guedj et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient Replication of Genotype 3a and 4a Hepatitis C Virus Replicons in Human Hepatoma Cells
- (2012) Mohsan Saeed et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
- (2012) Vincenzo Summa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase
- (2012) Jean-Michel Pawlotsky et al. ANTIVIRAL THERAPY
- Update on alisporivir in treatment of viral hepatitis C
- (2012) Robert Flisiak et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs
- (2012) Karolina Madela et al. Future Medicinal Chemistry
- Replication of Hepatitis C Virus Genotype 3a in Cultured Cells
- (2012) Mohsan Saeed et al. GASTROENTEROLOGY
- Development of Robust Hepatitis C Virus Genotype 4 Subgenomic Replicons
- (2012) Betty Peng et al. GASTROENTEROLOGY
- Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
- (2012) Shu-hao Hsu et al. JOURNAL OF CLINICAL INVESTIGATION
- MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
- (2012) Wei-Chih Tsai et al. JOURNAL OF CLINICAL INVESTIGATION
- Antiviral strategies in hepatitis C virus infection
- (2012) Christoph Sarrazin et al. JOURNAL OF HEPATOLOGY
- Evaluation of ITX 5061, a Scavenger Receptor B1 Antagonist: Resistance Selection and Activity in Combination With Other Hepatitis C Virus Antivirals
- (2012) Haihong Zhu et al. JOURNAL OF INFECTIOUS DISEASES
- Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
- (2012) R. T. Mosley et al. JOURNAL OF VIROLOGY
- Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
- (2012) Anna S. Lok et al. NEW ENGLAND JOURNAL OF MEDICINE
- The HCV Non-Nucleoside Inhibitor Tegobuvir Utilizes a Novel Mechanism of Action to Inhibit NS5B Polymerase Function
- (2012) Christy M. Hebner et al. PLoS One
- Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
- (2012) Y.-P. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
- (2012) Y.-P. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
- (2012) T. Shimakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication
- (2012) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct-acting and host-targeting HCV inhibitors: current and future directions
- (2012) Laurent Chatel-Chaix et al. Current Opinion in Virology
- The p7 Protein of Hepatitis C Virus Forms Structurally Plastic, Minimalist Ion Channels
- (2012) Danielle E. Chandler et al. PLoS Computational Biology
- Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity
- (2012) Annalisa Bianco et al. PLoS Pathogens
- Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
- (2012) Jamie J. Arnold et al. PLoS Pathogens
- The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors
- (2012) Keith P. Romano et al. PLoS Pathogens
- Molecular Determinants and Dynamics of Hepatitis C Virus Secretion
- (2012) Kelly E. Coller et al. PLoS Pathogens
- Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication
- (2012) Inés Romero-Brey et al. PLoS Pathogens
- Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
- (2011) I-hung Shih et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir
- (2011) Guanghui Yi et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B
- (2011) Roopa Rai et al. ANTIVIRAL RESEARCH
- Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment
- (2011) Simon Reiss et al. Cell Host & Microbe
- Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A
- (2011) Dries Verdegem et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus
- (2011) K. Morikawa et al. JOURNAL OF VIRAL HEPATITIS
- NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes
- (2011) D. Paul et al. JOURNAL OF VIROLOGY
- Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication
- (2011) K. L. Berger et al. JOURNAL OF VIROLOGY
- Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action
- (2011) P. Targett-Adams et al. JOURNAL OF VIROLOGY
- A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt
- (2011) William Sievert et al. LIVER INTERNATIONAL
- A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel
- (2011) Markus Cornberg et al. LIVER INTERNATIONAL
- Global health: A uniquely Egyptian epidemic
- (2011) Mohammed Yahia NATURE
- Boceprevir for Untreated Chronic HCV Genotype 1 Infection
- (2011) Fred Poordad et al. NEW ENGLAND JOURNAL OF MEDICINE
- Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection
- (2011) Bruce R. Bacon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telaprevir for Retreatment of HCV Infection
- (2011) Stefan Zeuzem et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection
- (2011) Ira M. Jacobson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hepatitis c virus and host cell lipids: An intimate connection
- (2011) Gualtiero Alvisi et al. RNA Biology
- HCV and HCC: Clinical Update and a Review of HCC-Associated Viral Mutations in theCoreGene
- (2011) Jawad Ahmad et al. SEMINARS IN LIVER DISEASE
- The Impact of Human Gene Polymorphisms on HCV Infection and Disease Outcome
- (2011) Esperance Schaefer et al. SEMINARS IN LIVER DISEASE
- Resistance to anti-HCV protease inhibitors
- (2011) Alexander J Thompson et al. Current Opinion in Virology
- Trafficking of Hepatitis C Virus Core Protein during Virus Particle Assembly
- (2011) Natalie A. Counihan et al. PLoS Pathogens
- Turning Hepatitis C into a Real Virus
- (2010) Catherine L. Murray et al. Annual Review of Microbiology
- Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System
- (2010) R. A. Fridell et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Prevalence and Challenges of Liver Diseases in Patients With Chronic Hepatitis C Virus Infection
- (2010) Ira M. Jacobson et al. Clinical Gastroenterology and Hepatology
- Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses
- (2010) Michael Houghton IMMUNOLOGICAL REVIEWS
- Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis
- (2010) Déborah Harrus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes
- (2010) P. Ferraris et al. JOURNAL OF GENERAL VIROLOGY
- Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- (2010) Michael J. Sofia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amphipathic -Helix AH2 Is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B
- (2010) J. Gouttenoire et al. JOURNAL OF VIROLOGY
- The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly
- (2010) T. Phan et al. JOURNAL OF VIROLOGY
- Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A
- (2010) Y.-C. Chen et al. JOURNAL OF VIROLOGY
- Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins
- (2010) J. Hwang et al. JOURNAL OF VIROLOGY
- Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
- (2010) Min Gao et al. NATURE
- DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A
- (2010) Lotte Coelmont et al. PLoS One
- Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory
- (2010) Jérôme Gouttenoire et al. REVIEWS IN MEDICAL VIROLOGY
- Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B
- (2010) N.-J. Cho et al. Science Translational Medicine
- Assembly of infectious hepatitis C virus particles
- (2010) Ralf Bartenschlager et al. TRENDS IN MICROBIOLOGY
- Recent Advances in Hepatitis C Virus Cell Entry
- (2010) Birke Bartosch et al. Viruses-Basel
- Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B
- (2010) Megan H. Powdrill et al. Viruses-Basel
- Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral Therapy
- (2010) Eike Steinmann et al. Viruses-Basel
- Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production
- (2010) Ann L. Wozniak et al. PLoS Pathogens
- Biochemical Characterization of Recombinant Hepatitis C Virus Nonstructural Protein 4B: Evidence for ATP/GTP Hydrolysis and Adenylate Kinase Activity†
- (2009) Aaron A. Thompson et al. BIOCHEMISTRY
- Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B
- (2009) Xavier Hanoulle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase
- (2009) P. Simister et al. JOURNAL OF VIROLOGY
- Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B
- (2009) J. Gouttenoire et al. JOURNAL OF VIROLOGY
- Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex
- (2009) Z. Liu et al. JOURNAL OF VIROLOGY
- Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
- (2009) R. A. Love et al. JOURNAL OF VIROLOGY
- The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy
- (2009) P. Luik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
- (2009) R. E. Lanford et al. SCIENCE
- Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
- (2009) Artur Kaul et al. PLoS Pathogens
- Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations
- (2009) Thomas Pietschmann et al. PLoS Pathogens
- Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796
- (2008) A. Y. M. Howe et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome
- (2008) Catherine L. Jopling et al. Cell Host & Microbe
- microRNA-122 stimulates translation of hepatitis C virus RNA
- (2008) Jura Inga Henke et al. EMBO JOURNAL
- Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro
- (2008) F. Yang et al. JOURNAL OF VIROLOGY
- The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus
- (2008) D. M. Jones et al. JOURNAL OF VIROLOGY
- Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
- (2008) T. Masaki et al. JOURNAL OF VIROLOGY
- Hepatitis C virus infection protein network
- (2008) B de Chassey et al. Molecular Systems Biology
- Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
- (2008) Shirit Einav et al. NATURE BIOTECHNOLOGY
- Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
- (2008) V. Brass et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly
- (2008) Nicole Appel et al. PLoS Pathogens
- Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
- (2008) Timothy L. Tellinghuisen et al. PLoS Pathogens
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