Effects of Variations in Ligand Density on Cell Signaling

Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

(2014) Andrew V. Dix et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Materials as stem cell regulators

(2014) William L. Murphy et al.   NATURE MATERIALS

Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays

(2013) Eric H. Nguyen et al.   BIOMATERIALS

Glycopolymer probes of signal transduction

(2013) Laura L. Kiessling et al.   CHEMICAL SOCIETY REVIEWS

Nanoscale Ligand Spacing Influences Receptor Triggering in T Cells and NK Cells

(2013) Derfogail Delcassian et al.   NANO LETTERS

Glycosaminoglycan-Binding Hydrogels Enable Mechanical Control of Human Pluripotent Stem Cell Self-Renewal

(2012) Samira Musah et al.   ACS Nano

Applications of peptide nucleic acids (PNAs) and locked nucleic acids (LNAs) in biosensor development

(2012) Carlos Briones et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Directing Stem Cell Fate by Controlling the Affinity and Density of Ligand-Receptor Interactions at the Biomaterials Interface

(2012) Kristopher A. Kilian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A chemically-defined screening platform reveals behavioral similarities between primary human mesenchymal stem cells and endothelial cells

(2012) Justin T. Koepsel et al.   Integrative Biology

Differential effects of a soluble or immobilized VEGFR-binding peptide

(2012) Justin T. Koepsel et al.   Integrative Biology

Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour

(2012) J. E. Frith et al.   JOURNAL OF CELL SCIENCE

Sequence, Structure, and Function of Peptide Self-Assembled Monolayers

(2012) Ann K. Nowinski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds

(2012) Ethan A. Englund et al.   Nature Communications

Surfaces That Sequester Serum-Borne Heparin Amplify Growth Factor Activity

(2011) Gregory A. Hudalla et al.   ADVANCED MATERIALS

Unforeseen decreases in dissolved oxygen levels affect tube formation kinetics in collagen gels

(2011) Hasan Erbil Abaci et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

Nanopatterning by block copolymer micelle nanolithography and bioinspired applications

(2011) Theobald Lohmüller et al.   Biointerphases

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Spacing of Integrin Ligands Influences Signal Transduction in Endothelial Cells

(2011) Guillaume Le Saux et al.   BIOPHYSICAL JOURNAL

Impact of Local versus Global Ligand Density on Cellular Adhesion

(2011) Janosch A. Deeg et al.   NANO LETTERS

The Relative Importance of Topography and RGD Ligand Density for Endothelial Cell Adhesion

(2011) Guillaume Le Saux et al.   PLoS One

Spatial control of cell fate using synthetic surfaces to potentiate TGF-  signaling

(2011) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing super selectivity in multivalent nano-particle binding

(2011) F. J. Martinez-Veracoechea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of a Cell Adhesion Receptor Stimulates Cell Migration

(2010) Shagufta H. Shabbir et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials

(2010) Honggang Cui et al.   BIOPOLYMERS

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events

(2010) A. Sacharidou et al.   BLOOD

CYR61 Regulates BMP-2-dependent Osteoblast Differentiation through the αvβ3Integrin/Integrin-linked Kinase/ERK Pathway

(2010) Jen-Liang Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients

(2010) Amir Shamloo et al.   LAB ON A CHIP

Immobilization of Peptides with Distinct Biological Activities onto Stem Cell Culture Substrates Using Orthogonal Chemistries

(2010) Gregory A. Hudalla et al.   LANGMUIR

Peptide ligands that use a novel binding site to target both TGF-β receptors

(2010) Lingyin Li et al.   Molecular BioSystems

Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells

(2010) Zara Melkoumian et al.   NATURE BIOTECHNOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Supramolecular design of self-assembling nanofibers for cartilage regeneration

(2010) Ramille N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating the Gelation Properties of Self-Assembling Peptide Amphiphiles

(2009) Joel M. Anderson et al.   ACS Nano

Controlled Growth Factor Delivery for Tissue Engineering

(2009) Prakriti Tayalia et al.   ADVANCED MATERIALS

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling

(2009) Fahsai Kantawong et al.   BIOMATERIALS

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices

(2009) A. N. Stratman et al.   BLOOD

Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells

(2009) Donny Hanjaya-Putra et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Using “Click” Chemistry to Prepare SAM Substrates to Study Stem Cell Adhesion

(2009) Gregory A. Hudalla et al.   LANGMUIR

Patterning Discrete Stem Cell Culture Environments via Localized Self-Assembled Monolayer Replacement

(2009) Justin T. Koepsel et al.   LANGMUIR

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Physical approaches to biomaterial design

(2008) Samir Mitragotri et al.   NATURE MATERIALS

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

(2008) Jessamine P. Winer et al.   TISSUE ENGINEERING PART A