Journal
BIOPOLYMERS
Volume 94, Issue 1, Pages 1-18Publisher
WILEY
DOI: 10.1002/bip.21328
Keywords
peptide amphiphiles; self-assembly; peptides; nanofibers; one-dimensional nanostructures; bionano-technology; regenerative medicine
Categories
Funding
- US Department of Energy-Basic Energy Sciences [DE-FG02-00ER45810]
- National Science Foundation [DMR-0605427, DMR-0520513, NSEC EEC-0647560]
- National Institute of Health Contract [NIH/NIBIB 5 R01 EB003806, NIH/NIDCR 5 R01 DE015920-3, NIH/NCI 5 U54 CA119341-04, NIH/NINDS 5 P50 NS054287-04, 5T90-DA022881]
- Division Of Materials Research [1006713] Funding Source: National Science Foundation
- NATIONAL CANCER INSTITUTE [U54CA119341] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015920] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS054287] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [T90DA022881] Funding Source: NIH RePORTER
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Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration. on and replacement. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 1-18, 2010.
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