Including known covariates can reduce power to detect genetic effects in case-control studies

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

(2011) Daniel I Chasman et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Underestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes

(2011) Sven Stringer et al.   PLoS One

On the relative efficiency of using summary statistics versus individual-level data in meta-analysis

(2010) D. Y. Lin et al.   BIOMETRIKA

Adjusting for covariates in logistic regression models

(2010) Guan Xing et al.   GENETIC EPIDEMIOLOGY

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip

(2009) Chris C. A. Spencer et al.   PLoS Genetics