Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

Ex Vivo Programming of Dendritic Cells by Mitochondria-Targeted Nanoparticles to Produce Interferon-Gamma for Cancer Immunotherapy

(2013) Sean Marrache et al.   ACS Nano

Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis

(2013) Manige Konige et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Double Click: Dual Functionalized Polymeric Micelles with Antibodies and Peptides

(2013) Dianna P. Y. Chan et al.   BIOCONJUGATE CHEMISTRY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Targeting mitochondria: Strategies, innovations and challenges

(2013) Marvin Edeas et al.   MITOCHONDRION

“Click” Dendrimers as Anti-inflammatory Agents: With Insights into Their Binding from Molecular Modeling Studies

(2013) Kevin Neibert et al.   MOLECULAR PHARMACEUTICS

Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

(2013) Serge Mignani et al.   PROGRESS IN POLYMER SCIENCE

Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions

(2013) B. T. Worrell et al.   SCIENCE

Targeting Cancer Cells: Controlling the Binding and Internalization of Antibody-Functionalized Capsules

(2012) Angus P. R. Johnston et al.   ACS Nano

Dendrimers in biomedical applications—reflections on the field

(2012) Sönke Svenson et al.   ADVANCED DRUG DELIVERY REVIEWS

Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia

(2012) Armen Khatchadourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phospholipids and lipid droplets

(2012) Anke Penno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy: Emerging roles in lipid homeostasis and metabolic control

(2012) Patricia Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies

(2012) Gang Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation

(2012) J Boren et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Mitochondrial Control of Cellular Life, Stress, and Death

(2012) Lorenzo Galluzzi et al.   CIRCULATION RESEARCH

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking

(2012) Frances Heaney   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases

(2012) Tomohiro Nakamura et al.   EXPERIMENTAL NEUROLOGY

The impact of click chemistry in medicinal chemistry

(2012) Jingli Hou et al.   Expert Opinion on Drug Discovery

Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat--Store 'em Up or Burn 'em Down

(2012) S. D. Kohlwein et al.   GENETICS

A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv “Click Chemistry” targeted to αvβ3 integrin for therapy

(2012) Klaus Braun et al.   International Journal of Medical Sciences

Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier

(2012) Yuma Yamada et al.   MITOCHONDRION

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioconjugation with Strained Alkenes and Alkynes

(2011) Marjoke F. Debets et al.   ACCOUNTS OF CHEMICAL RESEARCH

Strain-Promoted “Click” Chemistry for Terminal Labeling of DNA

(2011) Isaac S. Marks et al.   BIOCONJUGATE CHEMISTRY

Design and Evaluation of Multifunctional Nanocarriers for Selective Delivery of Coenzyme Q10 to Mitochondria

(2011) Anjali Sharma et al.   BIOMACROMOLECULES

Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

(2011) Annie Castonguay et al.   CHEMICAL COMMUNICATIONS

Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide-Cyclooctyne Cycloaddition in the Solid Phase

(2011) Ishwar Singh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields

(2011) David E. Bordelon et al.   JOURNAL OF APPLIED PHYSICS

Mitochondrial Delivery of Biologically Active Molecules

(2011) Volkmar Weissig   PHARMACEUTICAL RESEARCH

Functionalization of Block Copolymer Vesicle Surfaces

(2011) Stefan Egli et al.   Polymers

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

Approaches for targeting mitochondria in cancer therapy

(2010) Gerard G.M. D'Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers

(2010) Ghareb M. Soliman et al.   BIOMATERIALS

Multivalent niacin nanoconjugates for delivery to cytoplasmic lipid droplets

(2010) Anjali Sharma et al.   BIOMATERIALS

Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions

(2010) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

High-Density DNA Functionalization by a Combination of Cu-Catalyzed and Cu-Free Click Chemistry

(2010) Katrin Gutsmiedl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Multi-tasking with Single Platform Dendrimers for Targeting Sub-Cellular Microenvironments

(2010) Rami Hourani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Therapeutic use of coenzyme Q10and coenzyme Q10-related compounds and formulations

(2010) Jose M Villalba et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling

(2010) Lester Packer et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Antioxidant idebenone-loaded nanoparticles based on chitosan and N-carboxymethylchitosan

(2010) Clarissa de M. Amorim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Polymers for Drug Delivery Systems

(2010) William B. Liechty et al.   Annual Review of Chemical and Biomolecular Engineering

Copper-Free Clickable Coatings

(2009) Luiz A. Canalle et al.   ADVANCED FUNCTIONAL MATERIALS

Selective Fluorescence Labeling of Lipids in Living Cells

(2009) Anne B. Neef et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry beyond Metal-Catalyzed Cycloaddition

(2009) C. Remzi Becer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Leukocyte lipid bodies — Biogenesis and functions in inflammation

(2009) Patricia T. Bozza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Unexpected In Vivo Anti-Inflammatory Activity Observed for Simple, Surface Functionalized Poly(amidoamine) Dendrimers

(2009) Abhay S. Chauhan et al.   BIOMACROMOLECULES

Nanoparticles in cellular drug delivery

(2009) Amir H. Faraji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

(2009) Ishwar Singh et al.   CHEMICAL COMMUNICATIONS

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

(2009) Rhiannon K. Iha et al.   CHEMICAL REVIEWS

“Click” Methodology for Synthesis of Functionalized [3]Catenanes: Toward Higher Interlocked Structures

(2009) Jackson D. Megiatto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diels-Alder “Click” Chemistry in Designing Dendritic Macromolecules

(2009) Grégory Franc et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

(2009) Meng Shi et al.   JOURNAL OF MATERIALS CHEMISTRY

Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach

(2009) Enrique Lallana et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Free “Click” Modification of DNA via Nitrile Oxide−Norbornene 1,3-Dipolar Cycloaddition

(2009) Katrin Gutsmiedl et al.   ORGANIC LETTERS

In situcrosslinked hydrogels formed using Cu(I)-free Huisgen cycloaddition reaction

(2009) Meredith Clark et al.   POLYMER INTERNATIONAL

Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry☆

(2008) J LUTZ et al.   ADVANCED DRUG DELIVERY REVIEWS

Dual Labeling of Biomolecules by Using Click Chemistry: A Sequential Approach

(2008) Péter Kele et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In VivoTumor Cell Targeting with “Click” Nanoparticles

(2008) Geoffrey von Maltzahn et al.   BIOCONJUGATE CHEMISTRY

Click Chemistry Functionalized Polymeric Nanoparticles Target Corneal Epithelial Cells through RGD-Cell Surface Receptors

(2008) Jiao Lu et al.   BIOCONJUGATE CHEMISTRY

Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives

(2008) Sally-Ann Poulsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of small molecule carbonic anhydrase IX inhibitors

(2008) Claudiu T. Supuran   BJU INTERNATIONAL

Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers

(2008) Jeremiah A. Johnson et al.   CHEMICAL COMMUNICATIONS

Dendrimer design using CuI-catalyzed alkyne–azide “click-chemistry”

(2008) Grégory Franc et al.   CHEMICAL COMMUNICATIONS

Gold nanoparticles synthesis and stabilization via new “clicked” polyethyleneglycol dendrimers

(2008) Elodie Boisselier et al.   CHEMICAL COMMUNICATIONS

Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides

(2008) Brendan L. Wilkinson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation

(2008) Xifei Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

General Method for Synthesis of Functionalized Macrocycles and Catenanes Utilizing “Click” Chemistry

(2008) Jackson D. Megiatto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polycationic β-Cyclodextrin “Click Clusters”:  Monodisperse and Versatile Scaffolds for Nucleic Acid Delivery

(2008) Sathya Srinivasachari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Click”‐Chemistry in Polymer and Material Science: the Update

(2008) Wolfgang H. Binder   MACROMOLECULAR RAPID COMMUNICATIONS

Polymer “Clicking” by CuAAC Reactions

(2008) Morten Meldal   MACROMOLECULAR RAPID COMMUNICATIONS

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo

(2008) Sarathi V. Boddapati et al.   NANO LETTERS

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

(2008) Christopher D. Hein et al.   PHARMACEUTICAL RESEARCH

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS