Article
Oncology
N. B. Pushpa, Kumar Satish Ravi, Prashant Durgapal
Summary: Despite the COVID-19 pandemic in 2020, the discovery of a new salivary gland became a hot topic in the medical community. The significance of this finding lies in its clinical relevance in radiotherapy of oropharyngeal carcinoma, but there are differing views due to the lack of substantial evidence. Efforts have been made to shed light on Tubarial glands with potential evidence.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Masa Mavri, Marjeta Candek-Potokar, Gregor Fazarinc, Martin Skrlep, Catrin S. Rutland, Bozidar Potocnik, Nina Batorek-Lukac, Valentina Kubale
Summary: Recent studies have shown hydrolysable tannins to have beneficial effects on animals, such as antimutagenic and anticarcinogenic properties. In a study testing tannins as a potential nutrient to reduce boar taint, significant enlargement of the parotid glands was observed, with increased functional activity of the salivary glands noted as a response to high tannin intake.
Article
Medicine, General & Internal
Despoina Pouloudi, Maria Manou, Panagiotis Sarantis, Nikolaos Tsoukalas, Gerasimos Tsourouflis, Eougken Dana, Michalis V. Karamouzis, Jerzy Klijanienko, Stamatios Theocharis
Summary: This study explored the immunohistochemical expression of HDAC-1, -2, -4, and -6 in SGTs and their potential as prognostic biomarkers. The results indicated that HDAC-2 expression was associated with longer overall survival in patients with malignant SGTs, while HDAC-2 positivity and absence of HDAC-6 expression were related to prolonged survival in patients with high-grade malignant SGTs. Moreover, high HDAC-2 expression was significantly associated with longer overall survival in high-grade malignant SGT patients.
Article
Oncology
Takuya Nakagawa, Jessica Santos, Chanond A. Nasamran, Prakriti Sen, Sayed Sadat, Abdula Monther, Joseph Bendik, Koji Ebisumoto, Jingjing Hu, Sebastian Preissl, Theresa Guo, Vera Vavinskaya, Kathleen M. Fisch, Joseph A. Califano
Summary: The gene expression profiles of salivary gland cells are associated with the occurrence of salivary gland cancers, indicating the existence of specific cell of origin in certain types of salivary gland cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Do Hyun Kim, Jun Myung Kang, Sung Won Kim, So-Hyun Kim, Jae Hoon Jung, Se Hwan Hwang
Summary: This study evaluated the diagnostic characteristics of ultrasonography for submandibular and parotid stone detection and compared it with other confirmatory methods. The results suggest that ultrasonography is useful for detecting submandibular and parotid gland stones, with higher diagnostic accuracy in the parotid gland.
Article
Pathology
Marie Csanyi-Bastien, Marie-Delphine Lanic, Ludivine Beaussire, Sandra Ferric, Arnaud Francois, Didier Meseure, Fabrice Jardin, Michel Wassef, Philippe Ruminy, Marick Lae
Summary: The study aimed to evaluate the utility of pan-TRK immunohistochemistry in distinguishing secretory carcinoma (SC) from other salivary gland tumors, with nuclear pan-TRK staining showing high specificity for SCs with ETV6-NTRK3 fusion. Pan-TRK staining serves as a strong diagnostic marker to distinguish SC from its mimics and select patients eligible for TRK inhibitor clinical trials.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fernanda Aragao Felix, Leorik Pereira da Silva, Maria Luiza Diniz de Sousa Lopes, Ana Paula Veras Sobral, Roseana de Almeida Freitas, Lelia Batista de Souza, Carlos Augusto Galvao Barboza
Summary: The immunohistochemical expression of BER and NER proteins in malignant salivary gland tumors indicates mechanisms of genotoxic control in these tumors. Dysregulation of XRCC1 expression serves as a prognostic predictor in the analyzed MSGTs.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Otorhinolaryngology
Kuauhyama Luna-Ortiz, Hugo Dominguez-Malagon, Guillermo E. Corredor-Alonso, Nancy Reynoso-Noveron, Cesar Herrera-Ponzanelli, Zelik Luna-Peteuil, Luis C. Zacarias-Ramon
Summary: Salivary ductal carcinoma is a rare entity with poor survival, similar histologically to breast ductal carcinoma but with important differences. Most cases are high-grade, positive for HER2 and AR, and have a high Ki-67 proliferative index.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Anatomy & Morphology
Arthur R. Hand, Cailyn X. G. Abramson, Keith A. Dressler
Summary: Tlx1 is a crucial gene in the development of salivary glands in mice, specifically in the differentiation of submandibular and sublingual gland acinar cells and granular convoluted ducts. The exact mechanism of Tlx1 regulation in salivary gland development and differentiation remains unknown.
JOURNAL OF ANATOMY
(2023)
Article
Pathology
Asterios Triantafyllou
Summary: The study examined the occurrence and distribution of degenerative nuclear changes in pleomorphic adenomas (PAs) of the salivary glands. A single case showed unique cellular and nuclear abnormalities, not associated with malignant transformation, but related to myomatous or schwannomatous cell phenotypes.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Endocrinology & Metabolism
Yu Feng Shang, Yi Yang Shen, Meng Chen Zhang, Min Chao Lv, Tong Ying Wang, Xue Qun Chen, Jun Lin
Summary: Saliva production and secretion are essential functions of the salivary glands, with multiple functions including moistening, digestion, mineralization, lubrication, and mucosal protection. Saliva undergoes dynamic changes in its chemical and physical properties during physiological and pathophysiological processes. The central nervous system regulates salivary secretion and function through various neurotransmitters and neuroreceptors. Salivary glands play a crucial role in innate and adaptive immunity and protection, and saliva contains potential biomarkers for monitoring and predicting health and disease in clinical practice and precision medicine.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Otorhinolaryngology
Marcos Custodio, Fabio Daumas Nunes, Albina Altemani, Fabricio Passador-Santos, Maria Fernanda Setubal Destro Rodrigues, Suzana C. O. M. de Sousa, Bruno Tavares Sedassari
Summary: This study aimed to evaluate the immunoexpression of breast hormonal receptors and milk-related proteins in secretory carcinoma of the salivary gland (SCsg) and other salivary gland tumours with prominent secretory activity. The results showed that most cases of SCsg were negative for prolactin and growth hormone receptors. However, lactoferrin exhibited a distinctive expression pattern in SCsg, making it a good marker for its differential diagnosis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Pathology
Lester D. R. Thompson, Justin A. Bishop
Summary: Salivary gland intraductal carcinoma (IDC) is a rare and confusing group of neoplasms, with various names, diagnostic criteria, and molecular findings. Different histologic appearances and growth patterns suggest multiple tumor categories, and invasion complicates the classification. Recent evidence on fusion-positive IDC helps separate these tumors based on molecular underpinnings. This article summarizes the historical group of 183 neoplasms classified under IDC and highlights unique histologic, immunohistochemistry, and molecular features for standardization and harmonization of nomenclature.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Review
Medicine, General & Internal
Yoshihiro Morita, Kana Kashima, Mao Suzuki, Hiroko Kinosada, Akari Teramoto, Yuka Matsumiya, Narikazu Uzawa
Summary: Renal cell carcinoma often leads to distant metastases, with a rare occurrence of metastasis to oral mucosal tissue. Clear cells are also found in some salivary gland cancers in the oral cavity, stressing the importance of differential diagnosis between metastatic renal cell carcinoma and malignant tumors of the salivary gland.
Review
Medicine, General & Internal
Kohei Okuyama, Yasuyuki Michi, Yoshihisa Kashima, Hirofumi Tomioka, Hideaki Hirai, Misaki Yokokawa, Yuko Yamagata, Takeshi Kuroshima, Yuriko Sato, Maiko Tsuchiya, Kou Kayamori, Tohru Ikeda, Hiroyuki Harada
Summary: Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor, especially uncommon in the minor salivary glands, with histological features that can make accurate diagnosis challenging. Two cases of EMC in minor salivary glands underwent intraoral tumor resection with good postoperative outcomes and no recurrence or metastasis at 31 and 16 months, respectively. The differences in anatomy, structure, and size of minor salivary glands compared to major salivary glands may pose difficulty in predicting EMCs in minor salivary glands.
Article
Hematology
Elias Campo, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla-Martinez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, Lorenzo Cerroni, Laurence de Leval, Stefan Dirnhofer, Ahmet Dogan, Andrew L. Feldman, Falko Fend, Jonathan W. Friedberg, Philippe Gaulard, Paolo Ghia, Steven M. Horwitz, Rebecca L. King, Gilles Salles, Jesus San-Miguel, John F. Seymour, Steven P. Treon, Julie M. Vose, Emanuele Zucca, Ranjana Advani, Stephen Ansell, Wing-Yan Au, Carlos Barrionuevo, Leif Bergsagel, Wing C. Chan, Jeffrey I. Cohen, Francesco d'Amore, Andrew Davies, Brunangelo Falini, Irene M. Ghobrial, John R. Goodlad, John G. Gribben, Eric D. Hsi, Brad S. Kahl, Won-Seog Kim, Shaji Kumar, Ann S. LaCasce, Camille Laurent, Georg Lenz, John P. Leonard, Michael P. Link, Armando Lopez-Guillermo, Maria Victoria Mateos, Elizabeth Macintyre, Ari M. Melnick, Franck Morschhauser, Shigeo Nakamura, Marina Narbaitz, Astrid Pavlovsky, Stefano A. Pileri, Miguel Piris, Barbara Pro, Vincent Rajkumar, Steven T. Rosen, Birgitta Sander, Laurie Sehn, Margaret A. Shipp, Sonali M. Smith, Louis M. Staudt, Catherine Thieblemont, Thomas Tousseyn, Wyndham H. Wilson, Tadashi Yoshino, Pier-Luigi Zinzani, Martin Dreyling, David W. Scott, Jane N. Winter, Andrew Zelenetz
Summary: Since 1994, the classification of lymphoid neoplasms has been continuously updated through international efforts, with recent progress driven by genomic studies. This proposal presents the International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors, which has refined diagnostic criteria and incorporated new insights from genomics.
Review
Pathology
Andrew L. Feldman, Camille Laurent, Marina Narbaitz, Shigeo Nakamura, Wing C. Chan, Laurence de Leval, Philippe Gaulard
Summary: This article discusses the classification and diagnostic evaluation of nodal T- and NK-cell lymphomas based on the 2022 International Consensus Classification of Mature Lymphoid Neoplasms (2022 ICC). It highlights the grouping of T-follicular helper cell lymphoma into a single entity with three subtypes, as well as the genetic subtype of ALK-negative anaplastic large cell lymphoma (ALCL) associated with DUSP22 rearrangement. The introduction of a new provisional entity, primary nodal EBV-positive T-/NK-cell lymphoma, is also mentioned, along with evolving molecular data indicating distinct subgroups within PTCL, NOS.
Article
Pathology
Come Sesboue, Jean Galtier, Marie Jeanneau, Annick Chauvel, Elodie Laharanne, Samuel Amintas, Jean-Philippe Merlio, Krimo Bouabdallah, Francois-Xavier Gros, Laurence de Leval, Audrey Gros, Marie Parrens
Summary: Distinguishing FL from NMZL can be difficult in cases with unusual morphologic and phenotypic features and without characteristic cytogenetic rearrangements. Ancillary techniques, such as FISH, RT-MLPA, and NGS, can provide diagnostic contributions for unclassified tumors. In this study, FISH detected 1p36 deletion in some FLs and unclassified tumors, while RT-MLPA signatures were associated with FL and NMZL subtypes. Combining RT-MLPA and NGS findings successfully discriminated most unclassified tumors towards FL or NMZL diagnosis.
Article
Pathology
Rita Sarkis, Olivier Burri, Claire Royer-Chardon, Frederica Schyrr, Sophie Blum, Mariangela Costanza, Stephane Cherix, Nathalie Piazzon, Carmen Barcena, Bettina Bisig, Valentina Nardi, Rossella Sarro, Giovanna Ambrosini, Martin Weigert, Olivier Spertini, Sabine Blum, Bart Deplancke, Arne Seitz, Laurence de Leval, Olaia Naveiras
Summary: Bone marrow cellularity assessment is crucial in evaluating bone marrow biopsies for hematologic and nonhematologic disorders. MarrowQuant 2.0 is an efficient digital hematopathology workflow that accurately quantifies the cellularity of human bone marrow biopsies by segmenting different compartments. This tool can be used for clinical research to explore biomarkers related to bone marrow stromal components.
Review
Pathology
Laurence de Leval, Andrew L. Feldman, Stefano Pileri, Shigeo Nakamura, Philippe Gaulard
Summary: Non-cutaneous extranodal NK/T cell lymphoproliferations are a rare group of tumors that primarily occur in the gastrointestinal tract, nasal area, spleen, and liver. Accurate diagnosis is crucial due to the diverse clinical presentations and similarities with other diseases.
Editorial Material
Microbiology
Sven Saussez, Luigi Angelo Vaira, Giacomo De Riu, Jerome R. Lechien
Article
Pharmacology & Pharmacy
Barbara Freis, Maria De Los Angeles Ramirez, Celine Kiefer, Sebastien Harlepp, Cristian Iacovita, Celine Henoumont, Christine Affolter-Zbaraszczuk, Florent Meyer, Damien Mertz, Anne Boos, Mariana Tasso, Sonia Furgiuele, Fabrice Journe, Sven Saussez, Sylvie Begin-Colin, Sophie Laurent
Summary: Functionalized iron oxide nanoparticles (IONPs) with different shapes and sizes are synthesized and coated with dendron molecules to ensure biocompatibility and colloidal stability. These IONPs show promise in combining magnetic hyperthermia (MH) and photothermia (PTT) for cancer therapy. The 22 nm nanospheres and the 19 nm nanocubes exhibit the most promising theranostic properties, including efficient MRI contrast and hyperthermia abilities.
Article
Computer Science, Artificial Intelligence
Adrien Foucart, Olivier Debeir, Christine Decaestecker
Summary: Biomedical image analysis competitions often use a single metric to rank participants, which makes it difficult to assess the strengths and weaknesses of algorithms. The MoNuSAC 2020 challenge provides an interesting opportunity to study the information lost by using entangled metrics by involving multiple capabilities and releasing prediction masks from different teams. The results analysis using Panoptic Quality (PQ) and disentangled metrics shows that PQ hides interesting aspects of the results and is sensitive to small changes in prediction masks, making it hard to interpret and draw insights from the results. Access to raw predictions from participating teams is necessary for better analysis and usefulness to the research community.
PATTERN RECOGNITION
(2023)
Review
Pathology
Leticia Quintanilla-Martinez, Camille Laurent, Lorinda Soma, Siok-Bian Ng, Fina Climent, Sarah L. L. Ondrejka, Alberto Zamo, Andrew Wotherspoon, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology workshop in Florence, Italy discussed emerging entities and molecular subgroups in large B-cell lymphomas (LBCLs). The session focused on newly recognized diseases and their diagnostic challenges. Topics included high-grade/large B-cell lymphoma with 11q aberration (HG/LBCL-11q), LBCL with IRF4 rearrangement (LBCL-IRF4), primary bone diffuse large B-cell lymphoma (PB-DLBCL), and B-acute lymphoblastic leukemia (B-ALL) with IGH::MYC translocation.
Review
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Summary: Session 3 of the lymphoma workshop at the joint meeting of the European Association for Haematopathology and the Society for Hematopathology discussed splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas. The case review emphasized the challenges in diagnosing marginal zone lymphomas, including distinguishing between different types and the need for molecular studies to establish a final diagnosis. The workshop also addressed the overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma.
Correction
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Review
Pathology
Fina Climent, Alina Nicolae, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Sarah L. Ondrejka, Lorinda Soma, Andrew Wotherspoon, Alberto Zamo, Leticia Quintanilla-Martinez, Siok-Bian Ng
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop discussed cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases. Primary nodal-EBV-TNKL is a newly recognized entity associated with underlying immune deficiency/immune dysregulation. cPTCL-NOS demonstrates the TBX21 phenotype and shows an unexpected association with TFH lymphomas/LPDs.
Review
Medicine, General & Internal
Cyril Bouland, Xavier Vanden Eynden, Martin Lalmand, Thibaut Buset, Antoine Yanni, Rokneddine Javadian, Alexandra Rodriguez, Isabelle Loeb, Jerome R. Lechien, Fabrice Journe, Sven Saussez, Didier Dequanter
Summary: This systematic review examines the role of metformin in the prevention and treatment of head and neck cancer (HNC). The results suggest a protective effect of metformin in reducing HNC incidence. However, there is no consensus on its therapeutic effects. Metformin appears to improve cancer-related survival rates in diabetic patients, but no advantages were found compared to non-diabetic population. Further studies are needed to evaluate the effect of metformin on cancer-related survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Pathology
K. Ioannidou, D. Comte, A. Clottu, L. de Leval, C. Petrovas
Meeting Abstract
Pathology
J. Dagher, N. Scamuffa, V. Vocat-Mottier, K. Lefort, L. de Leval, B. Bisig, E. Missiaglia
