The Sec translocon mediated protein transport in prokaryotes and eukaryotes

ProteinO-Mannosyltransferases Associate with the Translocon to Modify Translocating Polypeptide Chains

(2014) Martin Loibl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

Phosphatidylserine-binding protein lactadherin inhibits protein translocation across the ER membrane

(2013) Hitoshi Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of Signal Peptide Peptidase A with C-Termini Bound in the Active Sites: Insights into Specificity, Self-Processing, and Regulation

(2013) Sung-Eun Nam et al.   BIOCHEMISTRY

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

(2013) Matthias Voss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Co-translational targeting and translocation of proteins to the endoplasmic reticulum

(2013) Yvonne Nyathi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Take the (RN)A-train: Localization of mRNA to the endoplasmic reticulum

(2013) Orit Hermesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRAP assists membrane protein topogenesis at the mammalian ER membrane

(2013) Nicole Sommer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

Seaside transportation—from structure to function of translocation machines

(2013) Trevor Lithgow et al.   EMBO REPORTS

Characterization of the supporting role of SecE in protein translocation

(2013) Jelger A. Lycklama a Nijeholt et al.   FEBS LETTERS

The Bacterial Translocon SecYEG Opens upon Ribosome Binding

(2013) Denis G. Knyazev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

(2013) Johannes H. Reithinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YidC Occupies the Lateral Gate of the SecYEG Translocon and Is Sequentially Displaced by a Nascent Membrane Protein

(2013) Ilie Sachelaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

(2013) David Akopian et al.   JOURNAL OF CELL BIOLOGY

Quantitative Analysis of SecYEG-Mediated Insertion of Transmembrane α-Helices into the Bacterial Inner Membrane

(2013) Karin Öjemalm et al.   JOURNAL OF MOLECULAR BIOLOGY

Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae

(2013) Judith Kraut-Cohen et al.   MOLECULAR BIOLOGY OF THE CELL

The C-terminal regions of YidC fromRhodopirellula balticaandOceanicaulis alexandriibind to ribosomes and partially substitute for SRP receptor function inEscherichia coli

(2013) Ines Seitl et al.   MOLECULAR MICROBIOLOGY

Structure of the SecY channel during initiation of protein translocation

(2013) Eunyong Park et al.   NATURE

Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding

(2013) Arzu Sandikci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIMIBI twins in protein targeting and localization

(2013) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

(2013) Nicholas Johnson et al.   PLoS One

Functional asymmetry within the Sec61p translocon

(2013) E. Demirci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation

(2013) M. Moser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways

(2013) Renuka Kudva et al.   RESEARCH IN MICROBIOLOGY

Expanding the glycoengineering toolbox: the rise of bacterial N-linked protein glycosylation

(2013) Jenny L. Baker et al.   TRENDS IN BIOTECHNOLOGY

Endoplasmic Reticulum Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

(2013) V. Denic et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Pleiotropic Effects of Membrane Cholesterol upon Translocation of Protein across the Endoplasmic Reticulum Membrane

(2012) Hitoshi Yamamoto et al.   BIOCHEMISTRY

CK2 phosphorylation of human Sec63 regulates its interaction with Sec62

(2012) Emmanuel Ampofo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein quality control in organelles — AAA/FtsH story

(2012) Hanna Janska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

N-acetylation and phosphorylation of Sec complex subunits in the ER membrane

(2012) Christina Soromani et al.   BMC CELL BIOLOGY

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Palmitoylated calnexin is a key component of the ribosome-translocon complex

(2012) Asvin KK Lakkaraju et al.   EMBO JOURNAL

Competitive Binding of the SecA ATPase and Ribosomes to the SecYEG Translocon

(2012) Zht Cheng Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-dependent Generation of Dual Topology for a Membrane Protein

(2012) Mikhail Bogdanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex

(2012) Sarah Whitehouse et al.   JOURNAL OF CELL BIOLOGY

Co-operation between different targeting pathways during integration of a membrane protein

(2012) Rebecca Keller et al.   JOURNAL OF CELL BIOLOGY

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

Targeting of lumenal proteins across the thylakoid membrane

(2012) A. M. Albiniak et al.   JOURNAL OF EXPERIMENTAL BOTANY

Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems

(2012) Yubin Zhou et al.   Metallomics

Membrane Proteases in the Bacterial Protein Secretion and Quality Control Pathway

(2012) R. E. Dalbey et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

(2012) Anja Hoffmann et al.   MOLECULAR CELL

Membrane Protein TM Segments Are Retained at the Translocon during Integration until the Nascent Chain Cues FRET-Detected Release into Bulk Lipid

(2012) Bo Hou et al.   MOLECULAR CELL

Orientational Preferences of Neighboring Helices Can Drive ER Insertion of a Marginally Hydrophobic Transmembrane Helix

(2012) Karin Öjemalm et al.   MOLECULAR CELL

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

(2012) Nurzian Ismail et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution from the Prokaryotic to the Higher Plant Chloroplast Signal Recognition Particle: The Signal Recognition Particle RNA Is Conserved in Plastids of a Wide Range of Photosynthetic Organisms

(2012) C. Trager et al.   PLANT CELL

Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins

(2012) Andreas Mades et al.   PLoS One

Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes

(2012) Stefan Pfeffer et al.   STRUCTURE

Single rRNA Helices Bind Independently to the Protein-Conducting Channel SecYEG

(2012) Christina Behrens et al.   TRAFFIC

Regulation from within: the cytoskeleton in transmembrane signaling

(2012) Khuloud Jaqaman et al.   TRENDS IN CELL BIOLOGY

MPIase is a glycolipozyme essential for membrane protein integration

(2012) Ken-ichi Nishiyama et al.   Nature Communications

Structure of the SecY Complex Unlocked by a Preprotein Mimic

(2012) Dilem Hizlan et al.   Cell Reports

Assembly of Bacterial Inner Membrane Proteins

(2011) Ross E. Dalbey et al.   Annual Review of Biochemistry

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

(2011) Eugene Oh et al.   CELL

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Multiple SecA Molecules Drive Protein Translocation across a Single Translocon with SecG Inversion

(2011) Kazuhiro Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipids and Topological Rules of Membrane Protein Assembly

(2011) Heidi Vitrac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Role for Endoplasmic Reticulum-bound Ribosomes in Cellular Translation Identified by Ribosome Profiling

(2011) David W. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Insertion and Topology of the Translocating Chain-Associating Membrane Protein (TRAM)

(2011) Silvia Tamborero et al.   JOURNAL OF MOLECULAR BIOLOGY

Signal sequence–independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle

(2011) David Braig et al.   MOLECULAR BIOLOGY OF THE CELL

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle

(2011) Thomas Welte et al.   MOLECULAR BIOLOGY OF THE CELL

SecA Interacts with Ribosomes in Order to Facilitate Posttranslational Translocation in Bacteria

(2011) Damon Huber et al.   MOLECULAR CELL

The superoxide dismutase SodA is targeted to the periplasm in a SecA-dependent manner by a novel mechanism

(2011) Martin Krehenbrink et al.   MOLECULAR MICROBIOLOGY

Analysis of RNA localization and metabolism in single live bacterial cells: achievements and challenges

(2011) Natalia E. Broude   MOLECULAR MICROBIOLOGY

Structure and function of a membrane component SecDF that enhances protein export

(2011) Tomoya Tsukazaki et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal peptidase I: Cleaving the way to mature proteins

(2011) Sarah M. Auclair et al.   PROTEIN SCIENCE

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

Translation-Independent Localization of mRNA in E. coli

(2011) K. Nevo-Dinur et al.   SCIENCE

The Bacterial SRP Receptor, SecA and the Ribosome Use Overlapping Binding Sites on the SecY Translocon

(2011) Patrick Kuhn et al.   TRAFFIC

Is there a twist in the Escherichia coli signal recognition particle pathway?

(2011) Eitan Bibi   TRENDS IN BIOCHEMICAL SCIENCES

Protein Quality Control in the Bacterial Periplasm

(2010) Melisa Merdanovic et al.   Annual Review of Microbiology

Biogenesis of the signal recognition particle

(2010) Eileen Leung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Early targeting events during membrane protein biogenesis in Escherichia coli

(2010) Eitan Bibi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Crossing the membrane in Archaea, the third domain of life

(2010) Doron Calo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

GTPases and the origin of the ribosome

(2010) Hyman Hartman et al.   Biology Direct

PpiD is a player in the network of periplasmic chaperones in Escherichia coli

(2010) Yvonne Matern et al.   BMC MICROBIOLOGY

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

BiP Modulates the Affinity of Its Co-chaperone ERj1 for Ribosomes

(2010) Julia Benedix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Oligomeric State and Arrangement of the Active Bacterial Translocon

(2010) Karine Deville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting

(2010) Vinh Q. Lam et al.   JOURNAL OF CELL BIOLOGY

Bat3 promotes the membrane integration of tail-anchored proteins

(2010) P. Leznicki et al.   JOURNAL OF CELL SCIENCE

Ancestral and Derived Protein Import Pathways in the Mitochondrion of Reclinomonas americana

(2010) J. Tong et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial organization of the flow of genetic information in bacteria

(2010) Paula Montero Llopis et al.   NATURE

Protein glycosylation in bacteria: sweeter than ever

(2010) Harald Nothaft et al.   NATURE REVIEWS MICROBIOLOGY

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The action of cardiolipin on the bacterial translocon

(2010) V. A. M. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

Addressing mRNAs to the ER: cis sequences act up!

(2010) Judith Kraut-Cohen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Archaea Signal Recognition Particle Shows the Way

(2010) Christian Zwieb et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Lipid-Dependent Membrane Protein Topogenesis

(2009) William Dowhan et al.   Annual Review of Biochemistry

The ER-membrane-resident Hsp40 ERj1 is a novel substrate for protein kinase CK2

(2009) Claudia Götz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor

(2009) Miryana Mircheva et al.   BMC BIOLOGY

Functional characterization of the trans-membrane domain interactions of the Sec61 protein translocation complex beta-subunit

(2009) Xueqiang Zhao et al.   BMC CELL BIOLOGY

Sec61β, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.

(2009) Anshuman Kelkar et al.   BMC CELL BIOLOGY

The evolution of YidC/Oxa/Alb3 family in the three domains of life: a phylogenomic analysis

(2009) Yu-Juan Zhang et al.   BMC EVOLUTIONARY BIOLOGY

Protein transport across and into cell membranes in bacteria and archaea

(2009) Jijun Yuan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure, Binding, and Activity of Syd, a SecY-interacting Protein

(2009) Kush Dalal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase

(2009) Martin R. Pool   JOURNAL OF CELL BIOLOGY

Dissecting the physiological role of selective transmembrane-segment retention at the ER translocon

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Two Cooperating Helices Constitute the Lipid-binding Domain of the Bacterial SRP Receptor

(2009) David Braig et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane-integration Characteristics of Two ABC Transporters, CFTR and P-glycoprotein

(2009) Karl Enquist et al.   JOURNAL OF MOLECULAR BIOLOGY

YidC and Oxa1 Form Dimeric Insertion Pores on the Translating Ribosome

(2009) Rebecca Kohler et al.   MOLECULAR CELL

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Emerging role for the cytoskeleton as an organizer and regulator of translation

(2009) Seyun Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs

(2009) J. Prilusky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligosaccharyltransferase directly binds to ribosome at a location near the translocon-binding site

(2009) Y. Harada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple conformational switches in a GTPase complex control co-translational protein targeting

(2009) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Regulation of the Protein-Conducting Channel by a Bound Ribosome

(2009) James Gumbart et al.   STRUCTURE

N-glycan structures: recognition and processing in the ER

(2009) Markus Aebi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis

(2008) Nurzian Ismail et al.   BIOCHEMICAL JOURNAL

The Periplasmic Chaperone PpiD Interacts with Secretory Proteins Exiting from the SecYEG Translocon†

(2008) Raluca Antonoaea et al.   BIOCHEMISTRY

Escherichia coliSignal Peptide Peptidase A Is a Serine-Lysine Protease with a Lysine Recruited to the Nonconserved Amino-Terminal Domain in the S49 Protease Family†

(2008) Peng Wang et al.   BIOCHEMISTRY

Glycosylation diseases: Quo vadis?

(2008) Harry Schachter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

Plastid protein import and sorting: different paths to the same compartments

(2008) Kenneth Cline et al.   CURRENT OPINION IN PLANT BIOLOGY

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins

(2008) Edwin van Bloois et al.   FEBS LETTERS

The Roles of Pore Ring and Plug in the SecY Protein-conducting Channel

(2008) James Gumbart et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor

(2008) Benjamin Weiche et al.   JOURNAL OF MOLECULAR BIOLOGY

A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

(2008) Rouven Bingel-Erlenmeyer et al.   NATURE

A role for the two-helix finger of the SecA ATPase in protein translocation

(2008) Karl J. Erlandson et al.   NATURE

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE

Conformational transition of Sec machinery inferred from bacterial SecYE structures

(2008) Tomoya Tsukazaki et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus

(2008) Pascal F. Egea et al.   PLoS One

Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp

(2008) Svenja Jarchow et al.   PROTEOMICS

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

(2008) Jean-François Ménétret et al.   STRUCTURE

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry