Article
Computer Science, Artificial Intelligence
Yongkuan Yang, Jianchang Liu, Shubin Tan
Summary: Many MOEAs are developed to solve CMOPs, but they encounter low efficiency for steady-state CMOPs. This paper proposes a multi-objective evolutionary algorithm named FACE, which maintains the known feasible solution in the second population and evolves together with the main population. Performance comparisons show the efficiency and scalability of FACE for steady-state CMOPs.
APPLIED SOFT COMPUTING
(2021)
Article
Multidisciplinary Sciences
Shi Jiao, Chuanchuan Li, Fenghua Guo, Jinjin Zhang, Hui Zhang, Zhifa Cao, Wenjia Wang, Wenbo Bu, Mobin Lin, Junhong Lue, Zhaocai Zhou
Summary: Alteration of the size and stiffness of the nucleus triggered by environmental cues is important for eukaryotic cell fate and function. This study identifies the nuclear envelope proteins SUN1/2 as mechano-regulators of the nucleus during M1 polarization, and demonstrates that SUN1/2 proteins act as mechano-regulators to remodel the nucleus and chromatin for M1 polarization of the macrophage in response to inflammatory cues.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Koh Takeuchi, Yutaka Kofuku, Shunsuke Imai, Takumi Ueda, Yuji Tokunaga, Yuki Toyama, Yutaro Shiraishi, Ichio Shimada
Summary: Multi-spanning membrane proteins transfer information and materials through a membrane by changing their conformations, and their dynamics are closely related to their function. NMR reveals dynamics information that can discriminate function-related dynamics from random fluctuations. Studies using solution NMR have contributed to revealing the structural basis of the function of multi-spanning membrane proteins.
Article
Biology
Thomas Baeriswyl, Alexandre Dumoulin, Martina Schaettin, Georgia Tsapara, Vera Niederkofler, Denise Helbling, Evelyn Aviles, Jeannine A. Frei, Nicole H. Wilson, Matthias Gesemann, Beat Kunz, Esther T. Stoeckli
Summary: Endoglycan functions as a negative regulator of cell-cell adhesion in axon guidance, playing a role in fine-tuning interactions rather than acting as a guidance cue or receptor.
Review
Biochemistry & Molecular Biology
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye
Summary: This review summarizes the mechanisms by which Epstein-Barr virus modulates tumor suppressor genes in associated cancers, ultimately promoting malignancies.
Article
Cell Biology
Jialin Zhou, Martin Jung, Kai S. Dimmer, Doron Rapaport
Summary: In this study, we investigated the biogenesis of multi-span proteins in the mitochondrial outer membrane. Our findings suggest that the targeting specificity and efficiency of these proteins are influenced by their length, as well as the behavior of the membrane. Additionally, cytosolic proteins do not significantly contribute to the biogenesis process.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Simona Ricciardi, Andrea Maria Guarino, Laura Giaquinto, Elena Polishchuk, Michele Santoro, Giuseppe Di Tullio, Cathal Wilson, Francesco Panariello, Vinicius C. Soares, Suelen S. G. Dias, Julia C. Santos, Thiago M. L. Souza, Giovanna Fusco, Maurizio Viscardi, Sergio Brandi, Patricia T. Bozza, Roman S. Polishchuk, Rossella Venditti, Maria Antonietta De Matteis
Summary: The replication organelle of SARS-CoV-2 is generated by viral non-structural proteins (NSPs) NSP3 and NSP4, while NSP6 plays a role in connecting ER membranes and organizing DMV clusters. NSP6 also mediates the contact between SARS-CoV-2 and lipid droplets (LDs), providing a means to refurbish the replication organelle with LD-derived lipids.
Article
Immunology
Ajay Kumar, Vivek P. Varma, Kavela Sridhar, Mohd Abdullah, Pallavi Vyas, Muhammed Ashiq Thalappil, Yung-Fu Chang, Syed M. Faisal
Summary: The study identified the domain A(11) of Leptospira immunoglobulin-like protein A (LAV) as playing a crucial role in modulating host immune responses, leading to persistent infection in different hosts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Yangbin Shao, Liangfei Xu, Zunyan Hu, Ling Xu, Xinyi Jia, Xiyuan Zhang, Yang Zhao, Jianqiu Li, Minggao Ouyang
Summary: Polymer electrolyte membrane fuel cell (PEMFC) is a potential power source for electrified transportation. Its highly non-linear characteristic can cause unpredictability and non-repeatability, which poses challenges for performance testing and operation optimization. This study experimentally discovers the steady state multiplicity of a PEMFC and develops a numerical model to reveal the multi-physics coupling mechanisms, providing deeper insights into its complexity as a physical system.
JOURNAL OF POWER SOURCES
(2023)
Article
Multidisciplinary Sciences
Zachary T. Neeb, Alexander J. Ritter, Lokendra V. Chauhan, Sol Katzman, W. Ian Lipkin, Nischay Mishra, Jeremy R. Sanford
Summary: The study found that SARS-CoV-2 infection causes global changes in host gene expression and differential expression of many host miRNAs. In addition, an expanded landscape of SARS-CoV-2-derived small viral RNAs (svRNAs) was discovered, which are predicted to interact with differentially expressed host mRNAs and miRNAs. These findings suggest that svRNAs may play a role in the propagation of SARS-CoV-2 and antagonizing them may have therapeutic value.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Qiong Huang, Jiaojiao Zhu, Chenchen Qu, Yunhao Wang, Xiuli Hao, Wenli Chen, Peng Cai, Qiaoyun Huang
Summary: This study reveals the mechanisms by which different mineral-humic acid composites influence the transformation of antibiotic resistance genes (ARGs) in soils. The findings provide insights into the fate of ARGs in soil systems and suggest the potential of utilizing soil components to mitigate the spread of ARGs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiming Chen, Alexandra White, David C. Nelson, Diwakar Shukla
Summary: Witchweed is a parasitic weed that destroys crops globally each year, with its germination stimulated by strigolactones from host plants. The unique sensitivity of the strigolactone receptor ShHTL7 in witchweed has been hypothesized to be due to a large binding pocket volume enhancing substrate binding ability, as shown in biochemical and structural analyses.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Immunology
Marek Cebecauer
Summary: This review focuses on the potential role of lipids and lipid domains in the morphogenesis of microvilli in T cells. It discusses the clustering of sphingolipids with phosphoinositides at the plasma membrane and its impact on actin cytoskeleton reorganization, supporting the growth of microvilli. Critical regulators of microvilli morphogenesis in T cells remain unknown, and several candidates with potential to organize proteins and lipids in these structures are suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fan Yang, Yifei Zhang, Jingjing Liu, Muhammad Yousaf, Xinlei Yang
Summary: The importance of exploring the scientific mechanism of solid oxide cells at low operating temperatures, such as SIFC and SMFC, and the challenges faced in achieving higher nominal peak power density are highlighted in this study. By modifying the QSS characterization testing process, it was found that QSS power density provides a better approximation for the real performance of fuel cells.
Article
Robotics
Hongliang Guo, Qi Kang, Wei-Yun Yau, Marcelo H. Ang Jr, Daniela Rus
Summary: This letter proposes an efficient iterative algorithm, named Entropy Maximized Patroller (EM-Patroller), to solve the multi-robot patrolling (MuRP) problem in a discrete environment. EM-Patroller achieves uniform node coverage probability distribution by reformulating the MuRP problem as an unnormalized joint steady state distribution entropy maximization problem. It uses the multi-layer perceptron (MLP) to model the relationship between each robot's patrolling strategy and the individual steady state distribution.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2023)
Article
Cell Biology
Tatjana Doering, Reinhild Prange
CELLULAR MICROBIOLOGY
(2015)
Article
Neurosciences
Torsten Bullmann, Gudrun Seeger, Jens Stieler, Janos Hanics, Katja Reimann, Tanja Petra Kretzschmann, Isabel Hilbrich, Max Holzer, Alan Alpar, Thomas Arendt
Review
Neurosciences
Thomas Arendt, Jens T. Stieler, Max Holzer
BRAIN RESEARCH BULLETIN
(2016)
Article
Virology
Christina Bartusch, Reinhild Prange
Review
Biochemistry & Molecular Biology
Thomas Arendt, Jens Stieler, Uwe Ueberham
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Virology
Christina Bartusch, Tatjana Doering, Reinhild Prange
Article
Virology
Tatjana Doering, Lisa Zeyen, Christina Bartusch, Reinhild Prange
JOURNAL OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Moritz Oberstadt, Jens Stieler, David Larbi Simpong, Ute Roemuss, Nicole Urban, Michael Schaefer, Thomas Arendt, Max Holzer
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Max Holzer, Nico Schade, Ansgar Opitz, Isabel Hilbrich, Jens Stieler, Tim Vogel, Valentina Neukel, Moritz Oberstadt, Frank Totzke, Christoph Schaechtele, Wolfgang Sippl, Andreas Hilgeroth
Article
Cell Biology
Lisa Zeyen, Tatjana Doering, Jens T. Stieler, Reinhild Prange
CELLULAR MICROBIOLOGY
(2020)
Article
Cell Biology
Lisa Zeyen, Tatjana Doering, Reinhild Prange
Article
Neurosciences
I. Friedrich, K. Reimann, S. Jankuhn, E. Kirilina, J. Stieler, M. Sonntag, J. Meijer, N. Weiskopf, T. Reinert, T. Arendt, M. Morawski
Summary: Iron is essential for neurons and glial cells but high concentrations of free iron can be detrimental, especially in neurodegenerative diseases. Changes in iron concentrations in the substantia nigra may play a key role in degeneration of dopaminergic neurons in Parkinson's disease. Quantitative analysis of iron provides insights into cellular iron levels in PD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Alexandra Bluhm, Sarah Schrempel, Sandra Moceri, Jens Stieler, Malte Feja, Stephan Schilling, Anja Schulze, Stephan von Hoersten, Maike Hartlage-Ruebsamen, Franziska Richter, Steffen Rossner
Summary: This study identifies a novel post-translational modification, pGlu79-αSyn, which promotes oligomer formation and neurotoxicity in synucleinopathies. MMP-3 and QC are implicated in the generation of pGlu79-αSyn in brains affected by αSyn pathology.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Cell Biology
Lisa Zeyen, Reinhild Prange
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)