Highlights in Antiviral Drug Research: Antivirals at the Horizon

CMX001 (1-O-Hexadecyloxypropyl-Cidofovir) Inhibits Polyomavirus JC Replication in Human Brain Progenitor-Derived Astrocytes

(2011) Rainer Gosert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

(2011) Angela M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

(2011) John H. Vernachio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β-d-2′-α-F-2′-β-C-Methylguanosine

(2011) Angela M. Lam et al.   ANTIVIRAL RESEARCH

Mechanistic Studies on a Novel Hydrophobic Derivative of Aglycoristocetin with Potent and Broad Activity Against Influenza Viruses

(2011) Evelien Vanderlinden et al.   ANTIVIRAL RESEARCH

Antiviral Activity of the MEK-inhibitor U0126 against Pandemic H1N1v and Highly Pathogenic Avian Influenza Virus In Vitro and In Vivo

(2011) Karoline Droebner et al.   ANTIVIRAL RESEARCH

Inhibition of Human Cytomegalovirus Replication by Tricin (4′,5,7-Trihydroxy-3′,5′-dimethoxyflavone)

(2011) Tsugiya Murayama et al.   ANTIVIRAL RESEARCH

Rigid Amphipathic Fusion Inhibitors (RAFIs) Inhibit Infectivity of Enveloped Viruses by Targeting Envelope Lipids to Prevent Fusion With Cellular Membranes

(2011) Che C. Colpitts et al.   ANTIVIRAL RESEARCH

CMX001 (Hexadecyloxypropyl Cidofovir) Antiviral Activity against Adenovirus in Patients Correlates with Drug Levels and Viral Sensitivity

(2011) E.R. Lanier et al.   ANTIVIRAL RESEARCH

Cyclopropavir Inhibits the Normal Function of the Human Cytomegalovirus UL97 Kinase

(2011) Mark Prichard et al.   ANTIVIRAL RESEARCH

OBR-5-340—A Novel Pyrazolo-Pyrimidine Derivative with Strong Antiviral Activity Against Coxsackievirus B3 In Vitro and In Vivo

(2011) Heike Braun et al.   ANTIVIRAL RESEARCH

Favipiravir (T-705) Treatment of Experimental Arenaviral Infection Initiated after the Onset of Clinical Disease

(2011) Brian B. Gowen et al.   ANTIVIRAL RESEARCH

Combinatorial Anti-arenaviral Therapy with the Small Molecule SKI-1/S1P Inhibitor PF-429242 and Ribavirin

(2011) Antonella Pasquato et al.   ANTIVIRAL RESEARCH

Identification and Characterization of OBR-5-340 – A Novel Broad-spectrum Anti-human Rhinovirus (HRV) Inhibitor

(2011) Martina Richter et al.   ANTIVIRAL RESEARCH

In Vivo Efficacy of N-methanocarbathymidine (N-MCT) against Herpes simplex Virus Type 2 in Neonatal Guinea Pigs

(2011) Rhonda Cardin et al.   ANTIVIRAL RESEARCH

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661

(2011) Phillip A. Furman et al.   ANTIVIRAL RESEARCH

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

(2011) Karoline Droebner et al.   ANTIVIRAL RESEARCH

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

(2011) Ruth Pinto et al.   ANTIVIRAL RESEARCH

Towards the design of combination therapy for the treatment of enterovirus infections

(2011) Hendrik Jan Thibaut et al.   ANTIVIRAL RESEARCH

Arenaviruses and hantaviruses: From epidemiology and genomics to antivirals

(2011) R.N. Charrel et al.   ANTIVIRAL RESEARCH

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

(2011) Heléne Norder et al.   ANTIVIRAL RESEARCH

Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia

(2011) Annick AJM van de Ven et al.   ANTIVIRAL THERAPY

Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine

(2011) Jacqueline Ruiz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Increased Bioavailability of Tricin−Amino Acid Derivatives via a Prodrug Approach

(2011) Masayuki Ninomiya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of PSI-352938: A β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

(2011) P. Ganapati Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Ribavirin Can Be Mutagenic for Arenaviruses

(2011) H. Moreno et al.   JOURNAL OF VIROLOGY

Design, synthesis, and biological evaluation of a biyouyanagin compound library

(2011) K. C. Nicolaou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arenavirus reverse genetics: New approaches for the investigation of arenavirus biology and development of antiviral strategies

(2011) Sebastien E. Emonet et al.   VIROLOGY

Efficacy of CMX001 as a Post Exposure Antiviral in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

(2011) Amanda D. Rice et al.   Viruses-Basel

Efficacy of CMX001 as a Prophylactic and Presymptomatic Antiviral Agent in New Zealand White Rabbits Infected with Rabbitpox Virus, a Model for Orthopoxvirus Infections of Humans

(2011) Amanda D. Rice et al.   Viruses-Basel

Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection

(2010) Fernando J. Bravo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

1-O-Hexadecyloxypropyl Cidofovir (CMX001) Effectively Inhibits Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial Cells

(2010) C. H. Rinaldo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hexadecyloxypropyl-Cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures

(2010) Z.-G. Jiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir

(2010) B. G. Gentry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility

(2010) Sunwen Chou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PSI-7851, a Pronucleotide of  -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

(2010) A. M. Lam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-705 (Favipiravir) Inhibition of Arenavirus Replication in Cell Culture

(2010) Michelle Mendenhall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses

(2010) K. Sleeman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model

(2010) Eric M. Vela et al.   ANTIVIRAL RESEARCH

Nigericin is a potent inhibitor of the early stage of vaccinia virus replication

(2010) Chad Myskiw et al.   ANTIVIRAL RESEARCH

Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid

(2010) Justin J. Pollara et al.   ANTIVIRAL RESEARCH

Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase

(2010) Brian G. Gentry et al.   BIOCHEMICAL PHARMACOLOGY

2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

(2010) P. Ganapati Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

(2010) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication

(2010) Martin Michaelis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Phase II Study of PD-0325901, an Oral MEK Inhibitor, in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer

(2010) E. B. Haura et al.   CLINICAL CANCER RESEARCH

Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever

(2010) José Sebastián Barradas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Treatment of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia

(2010) A. Patel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

(2010) Eisuke Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Specific Interaction of Small Molecule Entry Inhibitors with the Envelope Glycoprotein Complex of the Junín Hemorrhagic Fever Arenavirus

(2010) Celestine J. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eradication of disseminated adenovirus infection in a pediatric hematopoietic stem cell transplantation recipient using the novel antiviral agent CMX001

(2010) Kris Paolino et al.   JOURNAL OF CLINICAL VIROLOGY

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

(2010) Debra C. Quenelle et al.   JOURNAL OF INFECTIOUS DISEASES

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiviral Activity of a Small-Molecule Inhibitor of Arenavirus Glycoprotein Processing by the Cellular Site 1 Protease

(2010) S. Urata et al.   JOURNAL OF VIROLOGY

A Mouse Model of Lethal Infection for Evaluating Prophylactics and Therapeutics against Monkeypox Virus

(2010) J. Stabenow et al.   JOURNAL OF VIROLOGY

Infectious Lassa Virus, but Not Filoviruses, Is Restricted by BST-2/Tetherin

(2010) Sheli R. Radoshitzky et al.   JOURNAL OF VIROLOGY

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

(2010) Xiaoxuan Qi et al.   NATURE

Development of a New Tacaribe Arenavirus Infection Model and Its Use to Explore Antiviral Activity of a Novel Aristeromycin Analog

(2010) Brian B. Gowen et al.   PLoS One

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

(2010) M. R. St.Vincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways

(2010) Yi-Ying Lin et al.   THROMBOSIS AND HAEMOSTASIS

Novel approaches in anti-arenaviral drug development

(2010) Andrew M. Lee et al.   VIROLOGY

Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy

(2010) Nanhai Chen et al.   VIROLOGY

Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2

(2010) Hao Zhang et al.   VIRUS RESEARCH

Development of CMX001 for the Treatment of Poxvirus Infections

(2010) Randall Lanier et al.   Viruses-Basel

Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics

(2010) Scott Parker et al.   Viruses-Basel

Effects of the Combination of Favipiravir (T-705) and Oseltamivir on Influenza A Virus Infections in Mice

(2009) D. F. Smee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art

(2009) Karl Y. Hostetler   ANTIVIRAL RESEARCH

Effect of T-705 treatment on western equine encephalitis in a mouse model

(2009) Justin G. Julander et al.   ANTIVIRAL RESEARCH

Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3

(2009) Denise Werk et al.   ANTIVIRAL RESEARCH

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Anti-influenza virus activity and structure–activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains

(2009) Lieve Naesens et al.   ANTIVIRAL RESEARCH

Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models

(2009) Brian B. Gowen et al.   ANTIVIRAL RESEARCH

In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-β-D-glucopyranoside against Coxsackie Virus B3

(2009) Haiyan Zhu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity

(2009) Santosh B. Mhaske et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells

(2009) D. F. Smee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine

(2009) David B. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

(2009) Leire Aguado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots ofPhyllanthus emblica

(2009) Qing Liu et al.   JOURNAL OF NATURAL PRODUCTS

An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase

(2009) Peiyuan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Antiviral drug discovery: Ten more compounds, and ten more stories (part B)

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Another ten stories in antiviral drug discovery (part C): “Old” and “new” antivirals, strategies, and perspectives

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

T-705 (favipiravir) activity against lethal H5N1 influenza A viruses

(2009) M. Kiso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose

(2009) Olaf R. Ludek et al.   TETRAHEDRON

Cidofovir Inhibits Polyomavirus BK Replication in Human Renal Tubular Cells Downstream of Viral Early Gene Expression

(2008) E. Bernhoff et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Activity of T-705 in a Hamster Model of Yellow Fever Virus Infection in Comparison with That of a Chemically Related Compound, T-1106

(2008) J. G. Julander et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo

(2008) Mark Schleiss et al.   ANTIVIRAL RESEARCH

Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents

(2008) J MORREY et al.   ANTIVIRAL RESEARCH

New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3

(2008) Michaela Schmidtke et al.   ANTIVIRAL RESEARCH

D‐(+)‐iso‐Methanocarbathymidine: a High‐Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase

(2008) Maria J. Comin et al.   ChemMedChem

Unique Small Molecule Entry Inhibitors of Hemorrhagic Fever Arenaviruses

(2008) Andrew M. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals

(2008) J. L. Hawkins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C

(2008) A. M. De Palma et al.   JOURNAL OF VIROLOGY

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

(2008) R. A. Larson et al.   JOURNAL OF VIROLOGY

pH-Induced Activation of Arenavirus Membrane Fusion Is Antagonized by Small-Molecule Inhibitors

(2008) J. York et al.   JOURNAL OF VIROLOGY

The discovery of antiviral agents: Ten different compounds, ten different stories

(2008) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Selective inhibitors of picornavirus replication

(2008) Armando M. De Palma et al.   MEDICINAL RESEARCH REVIEWS

Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection

(2008) Liliana Soroceanu et al.   NATURE

Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses

(2008) H.J. Choi et al.   PHYTOMEDICINE

Treatment of Late Stage Disease in a Model of Arenaviral Hemorrhagic Fever: T-705 Efficacy and Reduced Toxicity Suggests an Alternative to Ribavirin

(2008) Brian B. Gowen et al.   PLoS One

Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

(2008) K. Toth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mousepox in the C57BL/6 strain provides an improved model for evaluating anti-poxvirus therapies

(2008) Scott Parker et al.   VIROLOGY

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

(2008) Mark N Prichard et al.   Virology Journal

Efficacy of therapeutic intervention with an oral ether–lipid analogue of cidofovir (CMX001) in a lethal mousepox model

(2007) Scott Parker et al.   ANTIVIRAL RESEARCH

Genistein treatment of cells inhibits arenavirus infection

(2007) Eric M. Vela et al.   ANTIVIRAL RESEARCH