Article
Multidisciplinary Sciences
Khairul Habib Alam, Yumnam Rohen, Naeem Saleem
Summary: This study aims to provide new classes of (alpha, beta, F*)-weak Geraghty contraction and (alpha, beta, F**)-weak Geraghty contraction, which are self-generalized contractions on any metric space. The study finds that the mappings satisfying the definition of such contractions have a unique fixed point if the underlying space is complete. Additionally, an application is provided to demonstrate the uniqueness of the solution to the two-point boundary value problem.
Article
Chemistry, Organic
Yuxiu Li, Xiangqian Li, Xiaowei Li, Dayong Shi
Summary: The direct synthesis of alpha-fluoro-beta-arylalkenyl sulfones without transition-metal and base conditions has been described, showing broad functional group compatibility and high stereoselectivity. This strategy is also applied to the late-stage modification of complex natural products and drugs.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Qian Wang, Jiang Liu, Nana Wang, Romana Pajkert, Haibo Mei, Gerd-Volker Roschenthaler, Jianlin Han
Summary: We report a one-pot reaction for the synthesis of azo-containing alpha-fluorovinylphosphonates using aza-Wittig reagents. Mechanism studies reveal a pathway involving aza-Wittig reaction, water addition, and C-F bond cleavage. This reaction provides a strategy for the synthesis of alpha-fluorovinylphosphonate derivatives.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Microbiology
Pierre Godessart, Adelie Lannoy, Marc Dieu, Sander E. Van der Verren, Patrice Soumillion, Jean-Francois Collet, Han Remaut, Patricia Renard, Xavier De Bolle
Summary: In alpha-proteobacteria, the outer membrane is covalently linked to the peptidoglycan through cross-links between beta-barrel-shaped proteins and peptidoglycan, catalyzed by l,d-transpeptidases. The presence of a conserved alanyl-aspartyl motif at the N-terminus of the anchored proteins is crucial for the stability of the outer membrane. This mechanism of attachment may be widespread in alpha-proteobacteria, with potential implications for envelope integrity.
NATURE MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiaoming Wang, Weilong Liu, Xiao Luo, Qian Zheng, Bing Shi, Renkai Liu, Chenghao Li
Summary: In this study, we investigated the exact mechanism of beta-catenin/F-actin in regulating palatal reorientation. We found that overexpression of beta-catenin disrupted F-actin responsible for cytoskeletal remodeling in palatal mesenchymal cells, leading to failed palatal elevation and visible cleft palate. Furthermore, we identified alpha-actinin-4 as a key mediator in the regulation of F-actin cytoskeleton reorganization by beta-catenin.
Article
Chemistry, Organic
Noah Jeremias, Lisa-Marie Mohr, Thorsten Bach
Summary: 2-Aryl-1-sulfonyl-substituted cyclobutanes were synthesized via an intermolecular [2 + 2] photocycloaddition using various alpha,beta-unsaturated sulfones and olefins. Lewis acids were employed to catalyze this reaction, with chiral-at-metal Lewis acid achieving enantioselective outcomes up to 77% ee.
Article
Chemistry, Organic
Zhongkang Dong, Hengzhi Zhang, Baiquan Wang, Bin Li
Summary: A novel Ru-catalyzed redox-neutral [4+2] cyclization of 2-arylbenzimidazoles with α-trifluoromethyl-α-diazoketones has been developed, incorporating sequential C-H activation and defluorinative annulation. This synthetic protocol enables modular and efficient access to 6-fluorobenzimidazo[2,1-a]isoquinolines with excellent functional group compatibility. The resulting monofluorinated heterocyclic products can be easily diversified by various nucleophiles.
Article
Chemistry, Organic
Vincenzo Marsicano, Gianpaolo Marraffa, Marco Chiarini, Laura Palombi, Antonio Arcadi
Summary: This study reports a viable one-pot synthesis of pharmacologically interesting benzo[c][2,7]naphthyridine-4,5(3H,6H)-diones and addresses the issue of product selectivity control in the synthesis.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Cheng Niu, Dong-Hua Xie, Da-Ming Du
Summary: An isothiourea-catalysed asymmetric Michael/lactamization cascade reaction of 2-aminobenzothiophenes and alpha,beta-unsaturated anhydrides was developed for the first time, yielding various benzothienopyridinones in good to excellent yields with excellent enantioselectivities.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Vincenzo Marsicano, Antonio Arcadi, Marco Chiarini, Giancarlo Fabrizi, Antonella Goggiamani, Antonia Iazzetti
Summary: The divergent domino condensation/biannulation reaction of beta-(2-aminophenyl) alpha,beta-ynones with 1,3-dicarbonyls to construct a polycyclic 4H-pyrano[3,4-c]quinoline core was developed, catalyzed by p-TsOH center dot H2O. The reaction proceeds in ethanol with good to excellent yields, providing a simple and effective method for the synthesis of functionalized 4H-pyrano[3,4-c]quinolinones. Further elaboration with an excess of 20% NH4OH in EtOH at 50 degrees C helps achieve the synthesis of the perlodinine analogues benzo[c][2,7]naphthyridin-4(3H)-one derivatives in high yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Applied
Meng-Yang Chang, Kuan-Ting Chen, Hsing-Yin Chen
Summary: In this study, a diverse range of substituted 2-thienylmethyl beta-ketosulfones were synthesized through a Grignard reagent-mediated and solvent-controlled 1,8-addition reaction. The reaction was conducted in a diethyl ether-dioxane cosolvent and dioxane (v/v=4/1) under ice-bath conditions, resulting in moderate yields. Additionally, the 1,4-addition reaction of alpha-heterocyclic beta-ketosulfones was also investigated, and the structure of the key product was confirmed using X-ray analysis. DFT calculations were employed to rationalize the regioselectivity of the 1,8-addition reaction.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Bo Zhu, Huihui Fan, Yanan Ding, Yubing Zhai, Le Wang, Mengqi Wang, Gongming Zhu, Junbiao Chang
Summary: In this study, a copper-catalyzed asymmetric cyclization reaction was developed for the synthesis of chiral pyrazolidine derivatives containing a trifluoromethyl moiety. The reaction showed excellent yields, enantioselectivities, and diastereoselectivities, and the resulting compounds exhibited promising biological activities against human cancer cell lines.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Qian Wang, Li Wang, Romana Pajkert, Ita Hajdin, Haibo Mei, Gerd-Volker Roeschenthaler, Jianlin Han
Summary: A new synthetic method has been reported using (β-diazo-α,α-difluoroethyl)phosphonates and α,β-unsaturated esters to prepare valuable pyrazoline carboxylates containing difluoromethylene phosphonates at high yields. The utility of this method has been demonstrated through large-scale synthesis.
JOURNAL OF FLUORINE CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yanli Bi, Danrui Cui, Xiufang Xiong, Yongchao Zhao
Summary: Beta-transducin repeat-containing protein (beta-TrCP) is a crucial protein involved in ubiquitination and proteasomal degradation of key regulators, regulating processes such as signal transduction and cell cycle. Dysregulation of beta-TrCP is commonly associated with tumorigenesis in human cancers, highlighting its potential as a therapeutic target for cancer treatment.
Article
Chemistry, Organic
Yihong Wang, Claire M. M. Young, David B. B. Cordes, Alexandra M. Z. Slawin, Andrew D. D. Smith
Summary: The isothiourea-catalyzed formal [2+ 2] cycloaddition of C(1)-alkyl and C(1)-unsubstituted ammonium enolates with beta- and alpha,beta-substituted trifluoromethylenones has been developed. The reaction exhibited preferential [2 + 2]-cycloaddition over the alternative [4 + 2]-cycloaddition, resulting in beta-lactones with excellent diastereo- and enantioselectivity. The regioselectivity of the reaction was determined by the substituents on both reactants.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
