Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation

Gap junction communication in myelinating glia

(2012) Anna Nualart-Marti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stress-Induced Neuroinflammation: Role of the Toll-Like Receptor-4 Pathway

(2012) Iciar Gárate et al.   BIOLOGICAL PSYCHIATRY

Perinatal stress, brain inflammation and risk of autism-Review and proposal

(2012) Asimenia Angelidou et al.   BMC Pediatrics

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma

(2012) J. D. Dougherty et al.   CANCER RESEARCH

Human intestinal mast cells are a potent source of multiple chemokines

(2012) Katrin Feuser et al.   CYTOKINE

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2012) Jilpa Patel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis

(2012) Magdalini Vasiadi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

(2012) Eliseo A. Eugenin et al.   Journal of Neuroimmune Pharmacology

Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin

(2012) Shahrzad Asadi et al.   Journal of Neuroinflammation

Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

(2012) Géraldine Arrode-Brusés et al.   Journal of Neuroinflammation

Stimulated Human Mast Cells Secrete Mitochondrial Components That Have Autocrine and Paracrine Inflammatory Actions

(2012) Bodi Zhang et al.   PLoS One

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

(2012) Konstantinos–Dionysios Alysandratos et al.   PLoS One

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Connexin hemichannel blockade improves outcomes in a model of fetal ischemia

(2011) Joanne O. Davidson et al.   ANNALS OF NEUROLOGY

Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults

(2011) Henrik Hagberg et al.   ANNALS OF NEUROLOGY

Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

The executioners sing a new song: killer caspases activate microglia

(2011) J L Venero et al.   CELL DEATH AND DIFFERENTIATION

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

IL-1 acts on T cells to enhance the magnitude of in vivo immune responses

(2011) S.Z. Ben-Sasson et al.   CYTOKINE

Modulation of neurite outgrowth by activation of calcium-permeable kainate receptors expressed by rat nociceptive-like dorsal root ganglion neurons

(2011) Donald J. Joseph et al.   Developmental Neurobiology

Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality

(2011) Laura M. Magnotti et al.   GLIA

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptors are key players in neurodegeneration

(2011) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis

(2011) Bodi Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreased Mitochondrial Function and Increased Brain Inflammation in Bipolar Disorder and Other Neuropsychiatric Diseases

(2011) Theoharis C. Theoharides et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Cutting Edge: Mast Cells Regulate Disease Severity in a Relapsing-Remitting Model of Multiple Sclerosis

(2011) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia

(2011) Kana Harada et al.   JOURNAL OF NEUROCHEMISTRY

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children

(2011) Bodi Zhang et al.   Journal of Neuroinflammation

Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures

(2011) Andrew J Steelman et al.   Journal of Neuroinflammation

Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity

(2011) N. Karpuk et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation

(2011) Malika Bsibsi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation

(2011) Tim Kees et al.   NEURO-ONCOLOGY

To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models

(2011) Urs Meyer et al.   NEUROPHARMACOLOGY

Mitochondrial Dysfunction Can Connect the Diverse Medical Symptoms Associated With Autism Spectrum Disorders

(2011) RICHARD E. FRYE et al.   PEDIATRIC RESEARCH

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial activation in a neuroinflammational animal model of schizophrenia — a pilot study

(2011) Georg Juckel et al.   SCHIZOPHRENIA RESEARCH

Mecanismos biológicos involucrados en la propagación del daño en el traumatismo encéfalo craneano

(2011) M. Rovegno et al.   Medicina Intensiva

Exposure to Prenatal Infection and Risk of Schizophrenia

(2011) Alan S. Brown   Frontiers in Psychiatry

Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

(2010) Rakhi Sharma et al.   ACTA NEUROPATHOLOGICA

Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?

(2010) Luigi Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cells of the oligodendroglial lineage, myelination, and remyelination

(2010) Veronique E. Miron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity

(2010) Julie Gibb et al.   BRAIN BEHAVIOR AND IMMUNITY

The immune systemʼs role in the biology of autism

(2010) Paula Goines et al.   CURRENT OPINION IN NEUROLOGY

Peptides Targeting Toll-Like Receptor Signalling Pathways for Novel Immune Therapeutics

(2010) Rosa Gomariz et al.   CURRENT PHARMACEUTICAL DESIGN

Changes in Melanocortin Expression and Inflammatory Pathways in Fetal Offspring of Nonhuman Primates Fed a High-Fat Diet

(2010) B. E. Grayson et al.   ENDOCRINOLOGY

Cell membrane permeabilization via connexin hemichannels in living and dying cells

(2010) Juan C. Sáez et al.   EXPERIMENTAL CELL RESEARCH

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Mitochondrial Dysfunction in Autism

(2010) Cecilia Giulivi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Involvement of SLC17A9-dependent Vesicular Exocytosis in the Mechanism of ATP Release during T Cell Activation

(2010) Akihiro Tokunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dexamethasone differentially regulates functional membrane properties in glioma cell lines and primary astrocytes in vitro

(2010) Daniel Hinkerohe et al.   JOURNAL OF NEURO-ONCOLOGY

Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors

(2010) SunJa Kim et al.   JOURNAL OF NEUROCHEMISTRY

Neurotensin is increased in serum of young children with autistic disorder

(2010) Asimenia Angelidou et al.   Journal of Neuroinflammation

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

(2010) Sandra Ribes et al.   NEUROSCIENCE LETTERS

Prenatal stress alters microglial development and distribution in postnatal rat brain

(2009) Beatriz Gómez-González et al.   ACTA NEUROPATHOLOGICA

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Cytokines and Glucocorticoid Receptor Signaling

(2009) Thaddeus W. W. Pace et al.   Annals of the New York Academy of Sciences

Toll-like Receptors in Multiple Sclerosis Mouse Experimental Models

(2009) Monica Marta   Annals of the New York Academy of Sciences

Immune defects in Alzheimer's disease: new medications development

(2009) John R Cashman et al.   BMC NEUROSCIENCE

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro

(2009) J.M. Dean et al.   BRAIN BEHAVIOR AND IMMUNITY

The Role of Toll-like Receptors in Perinatal Brain Injury

(2009) Carina Mallard et al.   CLINICS IN PERINATOLOGY

Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands

(2009) Salima Mrabet-Dahbi et al.   EXPERIMENTAL DERMATOLOGY

Autism: an emerging ‘neuroimmune disorder’ in search of therapy

(2009) Theoharis C Theoharides et al.   EXPERT OPINION ON PHARMACOTHERAPY

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

(2009) Juan A. Orellana et al.   GLIA

P2X7 receptors mediate ischemic damage to oligodendrocytes

(2009) Maria Domercq et al.   GLIA

Remyelination — An effective means of neuroprotection

(2009) Charlotte C. Bruce et al.   HORMONES AND BEHAVIOR

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders

(2009) Shuei Sugama   MEDICAL HYPOTHESES

Diverse effects of bacterial cell wall components on mast cell degranulation, cysteinyl leukotriene generation and migration

(2009) Maciej Wierzbicki et al.   MICROBIOLOGY AND IMMUNOLOGY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

(2009) Yuxuan Jin et al.   STROKE

Early-life programming of later-life brain and behavior: a critical role for the immune system

(2009) Staci D. Bilbo   Frontiers in Behavioral Neuroscience

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: Circulating and brain cytokines, plasma corticosterone and behavioral changes in mice

(2008) Julie Gibb et al.   BRAIN BEHAVIOR AND IMMUNITY

Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders

(2008) Sharifia Wills et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of the maternal immune system alters cerebellar development in the offspring

(2008) Limin Shi et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes

(2008) Hyemi Kim et al.   IMMUNOLOGY

Induction of IL-33 expression and activity in central nervous system glia

(2008) Chad A. Hudson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controls

(2008) Shawn Hayley et al.   JOURNAL OF NEUROIMMUNOLOGY

Differential microglial activation between acute stress and lipopolysaccharide treatment

(2008) Shuei Sugama et al.   JOURNAL OF NEUROIMMUNOLOGY

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor   Mediates Lipopolysaccharide-Induced Microglial Toxicity to Developing Oligodendrocytes When Astrocytes Are Present

(2008) J. Li et al.   JOURNAL OF NEUROSCIENCE

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

(2008) Ulkan Kilic et al.   NEUROBIOLOGY OF DISEASE

Immune Dysregulation and Chronic Stress among Older Adults: A Review

(2008) Jean-Philippe Gouin et al.   NEUROIMMUNOMODULATION

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE

Prenatal stress and risk for autism

(2008) D KINNEY et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling

Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct

(2007) Meejin Ahn et al.   JOURNAL OF NEUROSCIENCE RESEARCH