Astellas' Drug Discovery Strategy: Focus on Oncology

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

(2011) Kentaro Yamanaka et al.   CLINICAL CANCER RESEARCH

Targeted Drug Delivery Using Immunoconjugates

(2011) Maria Valentina Pasquetto et al.   JOURNAL OF IMMUNOTHERAPY

Identification and Relative Quantitation of an Orphan G-Protein Coupled Receptor SREB2 (GPR85) Protein in Tissue Using a Linear Ion Trap Mass Spectrometer

(2011) Masatoshi Yuri et al.   JOURNAL OF PROTEOME RESEARCH

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

A systems view of epithelial–mesenchymal transition signaling states

(2010) Stuart Thomson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

(2010) E. Buck et al.   MOLECULAR CANCER THERAPEUTICS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors

(2008) E. Buck et al.   CANCER RESEARCH

Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy

(2008) Stuart Thomson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Systematic classification of CDR-L3 in antibodies: Implications of the light chain subtypes and the VL-VH interface

(2008) Daisuke Kuroda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural classification of CDR-H3 revisited: A lesson in antibody modeling

(2008) Daisuke Kuroda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS