Oxidative stress in apoptosis and cancer: an update

From sentencing to execution – the processes of apoptosis

(2015) Kelly L. Moffitt et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Mitochondrial Superoxide Dismutase - Signals of Distinction

(2012) Sumitra Miriyala et al.   Anti-Cancer Agents in Medicinal Chemistry

Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide

(2012) Garry R. Buettner   Anti-Cancer Agents in Medicinal Chemistry

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Construction of a Graphene Oxide Based Noncovalent Multiple Nanosupramolecular Assembly as a Scaffold for Drug Delivery

(2012) Yang Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research

(2012) Susana Patricia Egusquiaguirre et al.   Clinical & Translational Oncology

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Anticancer Antioxidant Regulatory Functions of Phytochemicals

(2012) J. M. Mates et al.   CURRENT MEDICINAL CHEMISTRY

Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

(2012) James A. McCubrey et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor

(2012) Sartaj Tabassum et al.   DALTON TRANSACTIONS

MicroRNA as a novel drug target for cancer therapy

(2012) Xiaoxia Liu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Intracellular transduction and potential of Tat PTD and its analogs: from basic drug delivery mechanism to application

(2012) Xinke Zhang et al.   Expert Opinion on Drug Delivery

Enhancing intracellular taxane delivery: current role and perspectives of nanoparticle albumin-bound paclitaxel in the treatment of advanced breast cancer

(2012) Valentina Guarneri et al.   EXPERT OPINION ON PHARMACOTHERAPY

Inherited variations in theSODandGPXgene families and cancer risk

(2012) Arseniy E. Yuzhalin et al.   FREE RADICAL RESEARCH

Antioxidant activity of β-selenoamines and their capacity to mimic different enzymes

(2012) Alessandro de Souza Prestes et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers

(2012) Sebastien Boridy et al.   Nanomedicine

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

(2012) Arwa S. Kathiria et al.   PLoS One

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

(2012) H. Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanomedicine for Cancer: Lipid-Based Nanostructures for Drug Delivery and Monitoring

(2011) Yoshihisa Namiki et al.   ACCOUNTS OF CHEMICAL RESEARCH

The impact of cellular senescence in cancer therapy: is it true or not?

(2011) Yi Zhang et al.   ACTA PHARMACOLOGICA SINICA

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

(2011) Bradley S. Fleenor et al.   AGING CELL

Pathophysiology of Metabolic Alkalosis: A New Classification Based on the Centrality of Stimulated Collecting Duct Ion Transport

(2011) F. John Gennari   AMERICAN JOURNAL OF KIDNEY DISEASES

Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats

(2011) Francisca Rodriguez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pharmacological antioxidant strategies as therapeutic interventions for COPD

(2011) Irfan Rahman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New developments on the functions of coenzyme Q in mitochondria

(2011) Maria Luisa Genova et al.   BIOFACTORS

Acute myeloid leukaemia associated with Muir-Torre variant of hereditary non-polyposis colon cancer (HNPCC): implications for inherited and acquired mutations in DNA mismatch repair genes

(2011) Imran K. Tailor et al.   BRITISH JOURNAL OF HAEMATOLOGY

Oral RKS262 reduces tumor burden in a neuroblastoma xenograft animal model and mediates cytotoxicity through SAPK/JNK and ROS activation in vitro

(2011) Rakesh K. Singh et al.   CANCER BIOLOGY & THERAPY

Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells

(2011) Jing Zhao et al.   CANCER LETTERS

Identification of an Unintended Consequence of Nrf2-Directed Cytoprotection against a Key Tobacco Carcinogen plus a Counteracting Chemopreventive Intervention

(2011) J. D. Paonessa et al.   CANCER RESEARCH

Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence Factors

(2011) M. Horiguchi et al.   CANCER RESEARCH

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

MYC and Metastasis

(2011) A. Wolfer et al.   CANCER RESEARCH

microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2

(2011) Jing Nie et al.   CARCINOGENESIS

Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation

(2011) Osong Kwon et al.   CELLULAR SIGNALLING

Soluble Epoxide Hydrolase Inhibitors and their Potential for Treatment of Multiple Pathologic Conditions

(2011) R. H. Ingraham et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation

(2011) Yoko Aniya et al.   DRUG METABOLISM REVIEWS

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

(2011) Alberto J. Montero et al.   DRUGS

Chemotherapy treatment decision making by professionals and older patients with cancer: a narrative review of the literature

(2011) M. JOHNSON   EUROPEAN JOURNAL OF CANCER CARE

The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals

(2011) Angelo D’Alessandro et al.   Expert Review of Proteomics

Dynamic modeling and analysis of cancer cellular network motifs

(2011) Mathieu Cloutier et al.   Integrative Biology

Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells

(2011) Amit K. Maiti   INTERNATIONAL JOURNAL OF CANCER

D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD

(2011) Ekambaram Ganapathy et al.   INTERNATIONAL JOURNAL OF CANCER

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

(2011) Rassoul Dinarvand et al.   International Journal of Nanomedicine

The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering

(2011) Sonia Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Genetics Analysis of an Aniline Mustard Anticancer Agent Reveals Complex I of the Electron Transport Chain as a Target

(2011) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenously-added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation

(2011) Takako Tominaga et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeted Drug Delivery Using Immunoconjugates

(2011) Maria Valentina Pasquetto et al.   JOURNAL OF IMMUNOTHERAPY

Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury

(2011) Youn Joo Moon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondria Determine the Efficacy of Anticancer Agents that Interact with DNA but Not the Cytoskeleton

(2011) K. Hara et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples

(2011) Sona Pekova et al.   LEUKEMIA RESEARCH

The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging

(2011) Cheng Luo et al.   MEDICAL HYPOTHESES

Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival

(2011) P. Y. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer

(2011) R. Thomas et al.   MOLECULAR CANCER THERAPEUTICS

Aberrant signaling pathways in pancreatic cancer: A two compartment view

(2011) Angela L. McCleary-Wheeler et al.   MOLECULAR CARCINOGENESIS

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Nanoparticles for intracellular-targeted drug delivery

(2011) Cristiana S O Paulo et al.   NANOTECHNOLOGY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Mitosis as an anti-cancer target

(2011) A Janssen et al.   ONCOGENE

Discovery of IL-18 As a Novel Secreted Protein Contributing to Doxorubicin Resistance by Comparative Secretome Analysis of MCF-7 and MCF-7/Dox

(2011) Ling Yao et al.   PLoS One

Investigations into the role of inflammation in normal tissue response to irradiation

(2011) Richard Peter Hill et al.   RADIOTHERAPY AND ONCOLOGY

Role of telomeres and telomerase in cancer

(2011) Jerry W. Shay et al.   SEMINARS IN CANCER BIOLOGY

Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer

(2011) Koh Miura et al.   SURGERY TODAY

Anticancer therapy with checkpoint inhibitors: what, where and when?

(2011) Michelle D. Garrett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases

(2011) Sanna Kaivosaari et al.   XENOBIOTICA

Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

(2011) D Zong et al.   Cell Death & Disease

Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapy

(2010) Ali R. Jazirehi   ANTI-CANCER DRUGS

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Pioneer: Professor Irwin Fridovich

(2010) James A. Imlay   ANTIOXIDANTS & REDOX SIGNALING

Role of MnSOD and p66shc in Mitochondrial Response to p53

(2010) Giovambattista Pani et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics

(2010) Maliheh Safavi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Retargeting adenoviral vectors to improve gene transfer into tumors

(2010) R T Hogg et al.   CANCER GENE THERAPY

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

Targeting the p53 Pathway of Apoptosis

(2010) Joana D. Amaral et al.   CURRENT PHARMACEUTICAL DESIGN

MicroRNA regulation of core apoptosis pathways in cancer

(2010) Raquel T. Lima et al.   EUROPEAN JOURNAL OF CANCER

D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage

(2010) Takuya Kudoh et al.   EXPERIMENTAL CELL RESEARCH

Update on non-viral delivery methods for cancer therapy: possibilities of a drug delivery system with anticancer activities beyond delivery as a new therapeutic tool

(2010) Yasufumi Kaneda   Expert Opinion on Drug Delivery

Mechanism of the peroxidase activity of Cu, Zn superoxide dismutase

(2010) Stefan I. Liochev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

(2010) José M. Matés et al.   FREE RADICAL BIOLOGY AND MEDICINE

Model mice for tissue-specific deletion of the manganese superoxide dismutase gene

(2010) Takahiko Shimizu et al.   Geriatrics & Gerontology International

A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer

(2010) Ahmad A. Tarhini et al.   HUMAN GENE THERAPY

The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis

(2010) Craig M. Walsh et al.   IMMUNOLOGICAL REVIEWS

Energy Balance, Host-Related Factors, and Cancer Progression

(2010) Stephen D. Hursting et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Manganese superoxide dismutase vs. p53: Regulation of mitochondrial ROS

(2010) Aaron K. Holley et al.   MITOCHONDRION

“Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology

(2010) Andrew H. Wyllie   MOLECULAR NEUROBIOLOGY

What's fueling the biotech engine—2009–2010

(2010) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Lycopene and Chemotherapy Toxicity

(2010) Kazim Sahin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

Novel Synthetic SOD/Catalase Mimetics Can Mitigate Capillary Endothelial Cell Apoptosis Caused by Ionizing Radiation

(2010) Ekaterina Vorotnikova et al.   RADIATION RESEARCH

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Drug discovery and mutant p53

(2010) Magda M. Maslon et al.   TRENDS IN CELL BIOLOGY

Protonated Nanoparticle Surface Governing Ligand Tethering and Cellular Targeting

(2009) Abhilash Vincent et al.   ACS Nano

Hypoxia-induced downregulation of autophagy mediator Beclin-1 reduces the susceptibility of malignant intestinal epithelial cells to hypoxia-dependent apoptosis

(2009) Byong Hoon Yoo et al.   Autophagy

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

(2009) Hoogeun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

(2009) Damià Tormo et al.   CANCER CELL

Impaired DNA damage response — An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

(2009) Zbigniew Darzynkiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2

(2009) Nadja Bitomsky et al.   FEBS Journal

Glutamine homeostasis and mitochondrial dynamics

(2009) José M. Matés et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interventional effect ofGinkgo bilobaextract on the progression of gastric precancerous lesions in rats

(2009) Xiao Yun JIANG et al.   Journal of Digestive Diseases

Natural Antioxidants: Therapeutic Prospects for Cancer and Neurological Diseases

(2009) J. Mates et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Evaluation of Molecular Markers in a Rat Model of Mammary Carcinogenesis

(2009) G. Vinothini et al.   ONCOLOGY RESEARCH

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

(2008) José M. Matés et al.   ARCHIVES OF TOXICOLOGY

Extracellular Redox State Regulates Features Associated with Prostate Cancer Cell Invasion

(2008) L. Chaiswing et al.   CANCER RESEARCH

Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells

(2008) Brian P. James et al.   FREE RADICAL BIOLOGY AND MEDICINE

New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins

(2008) Valeria Lanza et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pulse Radiolysis Investigation on the Mechanism of the Catalytic Action of Mn(II)−Pentaazamacrocycle Compounds as Superoxide Dismutase Mimetics

(2008) Andrej Maroz et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Copper Complexes of Nicotinic-Aromatic Carboxylic Acids as Superoxide Dismutase Mimetics

(2008) Thummaruk Suksrichavalit et al.   MOLECULES

DNA Damage, Apoptosis and Langerhans Cells—Activators of UV-induced Immune Tolerance

(2008) Laura Timares et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Role of Reactive Oxygen Intermediates in Cellular Responses to Dietary Cancer Chemopreventive Agents

(2008) Jedrzej Antosiewicz et al.   PLANTA MEDICA