Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling

Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles

(2018) Stanley Chung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture

(2018) Albert J. Paul et al.   BIOTECHNOLOGY AND BIOENGINEERING

Unknown

(2018)   Biotechnology Journal

Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing

(2018) Kristin N Valente et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography

(2018) Cher Hui Goey et al.   mAbs

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media

(2018) Jianlin Xu et al.   mAbs

Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

(2018) Mauro Torres et al.   PLoS One

Unknown

(2018)   Biotechnology Journal

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

(2018) Deborah C. Mash et al.   Frontiers in Pharmacology

A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation

(2017) Peifeng Tang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions

(2017) Hengameh Aghamohseni et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

(2016) Sen Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

(2016) Aydin Golabgir et al.   BIOTECHNOLOGY ADVANCES

Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures

(2016) Cécile Toussaint et al.   JOURNAL OF BIOTECHNOLOGY

Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression

(2016) Christian Kaisermayer et al.   JOURNAL OF BIOTECHNOLOGY

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

(2016) Hooman Hefzi et al.   Cell Systems

Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture

(2016) Andrea Bedoya-López et al.   PLoS One

How does mild hypothermia affect monoclonal antibody glycosylation?

(2015) Si Nga Sou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures

(2015) Xintao Zhang et al.   BIOTECHNOLOGY LETTERS

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

(2015) Julián López-Meza et al.   CYTOTECHNOLOGY

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity

(2015) Tobias Klein et al.   JOURNAL OF BIOTECHNOLOGY

Mathematical Models Describing Chinese Hamster Ovary Cell Death Due to Electroporation In Vitro

(2015) Janja Dermol et al.   JOURNAL OF MEMBRANE BIOLOGY

Mammalian Cell Culture Process for Monoclonal Antibody Production: Nonlinear Modelling and Parameter Estimation

(2015) Dan Selişteanu et al.   Biomed Research International

Synchronized mammalian cell culture: Part II-population ensemble modeling and analysis for development of reproducible processes

(2014) Uwe Jandt et al.   BIOTECHNOLOGY PROGRESS

Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality

(2014) William C. Yang et al.   BIOTECHNOLOGY PROGRESS

Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody

(2014) L. M. Carrillo-Cocom et al.   CYTOTECHNOLOGY

Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation

(2014) Philip Jedrzejewski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Model-directed engineering of “difficult-to-express” monoclonal antibody production by Chinese hamster ovary cells

(2013) Leon P. Pybus et al.   BIOTECHNOLOGY AND BIOENGINEERING

Brown drug substance color investigation in cell culture manufacturing using chemically defined media: A case study

(2013) Jianlin Xu et al.   PROCESS BIOCHEMISTRY

CHO Quasispecies—Implications for Manufacturing Processes

(2013) Florian Wurm   Processes

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

Reduction of N-terminal methionylation while increasing titer by lowering metabolic and protein production rates in E. coli auto-induced fed-batch fermentation

(2012) Jianlin Xu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements

(2012) Chung-Jr Huang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Exploring the effect of mild hypothermia on CHO cell productivity

(2011) Silvana Becerra et al.   BIOCHEMICAL ENGINEERING JOURNAL

Mammalian cell protein expression for biopharmaceutical production

(2011) Jianwei Zhu   BIOTECHNOLOGY ADVANCES

Towards dynamic metabolic flux analysis in CHO cell cultures

(2011) Woo Suk Ahn et al.   Biotechnology Journal

Process analysis of reduced specific productivity of TNFR-Fc in Chinese hamster ovary cells at high cell density

(2011) Tian-Ci Kou et al.   PROCESS BIOCHEMISTRY

Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells

(2011) Ying Jing et al.   PROCESS BIOCHEMISTRY

Effect of culture temperature on TNFR-Fc productivity in recombinant glutamine synthetase-chinese hamster ovary cells

(2010) Li Fan et al.   BIOTECHNOLOGY LETTERS

Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

(2010) Srinivas Karra et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

High productivity of human recombinant beta-interferon from a low-temperature perfusion culture

(2010) J. Rodriguez et al.   JOURNAL OF BIOTECHNOLOGY

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Effects of culture conditions onN-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells

(2009) Michael C. Borys et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature

(2009) Young Kue Han et al.   BIOTECHNOLOGY PROGRESS

Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY PROGRESS

The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions

(2009) Jong Hyun Nam et al.   CYTOTECHNOLOGY

Temperature Reduction in Cultures of hGM-CSF-expressing CHO Cells: Effect on Productivity and Product Quality

(2005) Mariela Bollati-Fogolín et al.   BIOTECHNOLOGY PROGRESS

Effect of Low Culture Temperature on Specific Productivity and Transcription Level of Anti-4-1BB Antibody in Recombinant Chinese Hamster Ovary Cells

(2003) Sung Kwan Yoon et al.   BIOTECHNOLOGY PROGRESS