Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media

A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions

(2017) Hengameh Aghamohseni et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Manufacturing history of etanercept (Enbrel®): Consistency of product quality through major process revisions

(2017) Brian Hassett et al.   mAbs

Biosimilars in the European Union from comparability exercise to real world experience: What we achieved and what we still need to achieve

(2017) Cristina Scavone et al.   PHARMACOLOGICAL RESEARCH

Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

(2016) Sen Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality

(2016) Salina Louie et al.   BIOTECHNOLOGY AND BIOENGINEERING

GP2015, a proposed etanercept biosimilar: Pharmacokinetic similarity to its reference product and comparison of its autoinjector device with prefilled syringes

(2016) Oliver von Richter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

(2016) Sha Sha et al.   TRENDS IN BIOTECHNOLOGY

When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid

(2015) Chris Chumsae et al.   ANALYTICAL CHEMISTRY

A robust method for increasing Fc glycan high mannose level of recombinant antibodies

(2015) Chung-Jr Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins

(2015) Patrick Hossler et al.   BIOTECHNOLOGY PROGRESS

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

(2015) Shohei Kishishita et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities

(2015) Hangtian Song et al.   PHARMACEUTICAL RESEARCH

Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest

(2014) Gayle E Derfus et al.   mAbs

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

(2014) Bing Li et al.   mAbs

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Effect of cell culture medium components on color of formulated monoclonal antibody drug substance

(2013) Natarajan Vijayasankaran et al.   BIOTECHNOLOGY PROGRESS

Hydroxocobalamin association during cell culture results in pink therapeutic proteins

(2013) Kenneth M Prentice et al.   mAbs

Brown drug substance color investigation in cell culture manufacturing using chemically defined media: A case study

(2013) Jianlin Xu et al.   PROCESS BIOCHEMISTRY

CHO Quasispecies—Implications for Manufacturing Processes

(2013) Florian Wurm   Processes

Effects of high passage cultivation on CHO cells: a global analysis

(2012) T. F. Beckmann et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of the basic charge variants of a human IgG1

(2012) Timothy Kaschak et al.   mAbs

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Effect of process change from perfusion to fed-batch on product comparability for biosimilar monoclonal antibody

(2012) Soo-Young Lee et al.   PROCESS BIOCHEMISTRY

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

(2011) Efren Pacis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimizing amino acid composition of CHO cell culture media for a fusion protein production

(2011) Zizhuo Xing et al.   PROCESS BIOCHEMISTRY

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Role of iron and sodium citrate in animal protein-free CHO cell culture medium on cell growth and monoclonal antibody production

(2010) Yunling Bai et al.   BIOTECHNOLOGY PROGRESS

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Identification of cell culture conditions to controlN-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

(2009) Martin Gawlitzek et al.   BIOTECHNOLOGY AND BIOENGINEERING