Article
Plant Sciences
Steven Kuan-Hua Huang, Paolo Robert P. Bueno, Patrick Jay B. Garcia, Mon-Juan Lee, Kathlia A. De Castro-Cruz, Rhoda B. Leron, Po-Wei Tsai
Summary: This study evaluated the effects of Osmanthus fragrans flower extracts on prostate cancer cells and identified possible protein-ligand interactions. The extracts showed antioxidant, anti-inflammatory, and anti-cancer properties, and could be used for anticancer drug development.
Article
Pharmacology & Pharmacy
Jiao He, Qian Zhang, Cuiying Ma, Gabriel I. Giancaspro, Kaishun Bi, Qing Li
Summary: A novel workflow was developed for quickly differentiating between C. morifolium flower and C. indicum flower. Differences in anti-inflammatory effects and HPLC fingerprint analysis were used to identify markers and build a binary logistic regression equation for successful differentiation. The established workflow is rapid, effective, and highly feasible, providing a powerful tool for herb identification.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Forestry
Yuchen Qian, Linmiao Shan, Rong Zhao, Jinwu Tang, Cheng Zhang, Moxian Chen, Yifan Duan, Fuyuan Zhu
Summary: This review summarizes the current research on the flower color and fragrance of Osmanthus fragrans, highlighting the importance of isolating the components and genes related to these traits for molecular breeding and industrial utilization. It also emphasizes the potential for discovering novel natural products.
Article
Plant Sciences
Hongguo Chen, Xiangling Zeng, Jie Yang, Xuan Cai, Yumin Shi, Riru Zheng, Zhenqi Wang, Junyi Liu, Xinxin Yi, Siwei Xiao, Qiang Fu, Jingjing Zou, Caiyun Wang
Summary: The study analyzed the genome construction, floral color traits, and domestication history of the Chinese native plant Osmanthus fragrans, revealing significant differences among different cultivar groups, with varieties in the Dangui group undergoing more artificial selection. Significant quantitative trait loci and genomic regions associated with petal color were identified through a genome-wide association study.
HORTICULTURE RESEARCH
(2021)
Article
Plant Sciences
Taijia Qiu, Song Li, Kunkun Zhao, Diwen Jia, Fadi Chen, Lian Ding
Summary: The chrysanthemum is a widely used flower with high ornamental, edible, and medicinal value. This study compared and analyzed the development of different types of flower heads and florets in chrysanthemums. It was found that the dorsal domain of the petals played a crucial role in the morphological differentiation of florets and the formation of diverse flower head types.
Article
Biochemistry & Molecular Biology
Yong Ye, Shanshan Cao, Lixiao Shen, Yiguang Wang, Shiwei Zhong, Liyuan Yang, Zheng Xiao, Qiu Fang, Hongbo Zhao, Bin Dong
Summary: This study provides a comprehensive analysis of the CCCH gene family in Osmanthus fragrans. A total of 66 CCCH genes were identified, and their expression patterns in different tissues and under various stresses were examined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Yang Yang, Yunfeng Miao, Shiwei Zhong, Qiu Fang, Yiguang Wang, Bin Dong, Hongbo Zhao
Summary: Through genome-wide analysis of Osmanthus fragrans, it was found that most of the OfXTH genes are closely associated with the flower-opening period. Under low temperature conditions, the expression of OfXTH24, 27, 32, 35 and 36 genes significantly increased, suggesting their involvement in regulating flower opening in response to temperature changes. These results provide a foundation for the functional analysis of OfXTH genes and the exploration of the mechanism of flower opening in response to ambient temperature in O. fragrans.
Article
Plant Sciences
Yo-Seob Seo, Hyang Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Hyun-Hwa Lee, Deuk-Sil Oh, Jae-Sung Kim
Summary: The purpose of this study was to evaluate the anti-osteoporosis effects of Osmanthus fragrans leaf ethanol extract (OFLEE) in both bone marrow-derived macrophages (BMM) and animals with osteoporosis. OFLEE was found to suppress the formation of osteoclasts and the activation of various factors involved in osteoclastogenesis. It also downregulated several inflammatory factors and prevented osteoporotic bone loss in animals. These findings suggest that OFLEE could be a potential treatment option for osteoporosis.
Article
Plant Sciences
Yuxi Wang, Li-Jie Zhou, Yiguang Wang, Shenhui Liu, Zhiqiang Geng, Aiping Song, Jiafu Jiang, Sumei Chen, Fadi Chen
Summary: Flavonoids, specifically flavones and flavonols, play important roles in determining flower color and regulating plant growth and development. The expression of CmFNS and CmFLS genes in chrysanthemums have been shown to be crucial for flavone and flavonol biosynthesis, ultimately influencing flower coloration.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yue Wang, Yangyu Li, Wei Guo, Xiao Yang, Jiameng Qu, Mang Gao, Shuting Chen, Jiangru Dong, Qing Li, Tiejie Wang
Summary: This study examines the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs with similar origin. The study employs a combination of network pharmacology, molecular pharmacology, and metabolomics to investigate the similarities and differences in chemical components, efficacy, and mechanisms of action of the two herbs. The results show that while CMF and CIF have similar effects in lowering blood pressure, resistance to tissue damage, and improving dyslipidemia, they exhibit distinct effects in regulating inflammatory response, signaling pathways, lipid anabolism, and metabolic abnormalities. The study suggests that the comparable efficacies of CMF and CIF, despite their distinct mechanisms of action, may be attributed to the integration and counteraction of their different regulating capabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yoonjin Lee, Jaerin Lee, Mak-Soon Lee, Eugene Chang, Yangha Kim
Summary: Research showed that Chrysanthemum morifolium Ramat flower extract can alleviate obesity-induced inflammation and muscle mitochondrial changes, improve dyslipidemia, hepatic fat deposition, and systemic inflammation, and increase energy expenditure.
Article
Plant Sciences
Zhiyong Zhang, Yazhong Zhang, Long Wang, Tongcan Cui, Yuxin Wang, Junhui Chen, Wenlong Li
Summary: This study aimed to screen natural antioxidants in five medicinal Chrysanthemum morifolium varieties and develop a comprehensive quality control method based on antioxidant activity. A novel method combining on-line HPLC-DPPH, ESI-MS, and NIR spectra analysis was established. Sixteen antioxidants were identified and the developed spectral-antioxidant activity model showed excellent predictive ability.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Jung Kim, Dong Hee Kim, Han Sub Kwak, In-Sun Yu, Min Young Um
Summary: Polyphenols in chrysanthemum extract can suppress A2E-mediated damage to RPE cells, but other substances in the extract may also play a role.
Article
Plant Sciences
Chenghui Pan, Laijun Zhao, Dayun Zhao
Summary: The study introduced microwave-assisted deep eutectic solvent extraction (MA-DESE) for extracting antioxidant components from Osmanthus fragrans flower, offering a safe and eco-friendly alternative to traditional solvent extraction methods. By optimizing the parameters, higher antioxidant activity and a greater variety of antioxidant components were obtained from the MA-DESE extraction compared to traditional methods.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2021)
Article
Multidisciplinary Sciences
Emeka Godwin Anaduaka, Innocent Uzochukwu Okagu, Nene Orizu Uchendu, Lawrence Uchenna Sunday Ezeanyika, Benneth Chima Nwanguma
Summary: The study demonstrated that long-term administration of high doses of Myristica fragrans seed extracts can cause hepato-renal toxicities, including abnormal liver function and kidney damage.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Applied
Tsung-Hsien Tsai, Wen-Cheng Huang, Tsung-Jung Lien, Yu-Han Huang, Hsiang Chang, Chun-Hsien Yu, Po-Jung Tsai
FOOD AND AGRICULTURAL IMMUNOLOGY
(2017)
Article
Chemistry, Applied
Szu-Jung Chen, Hung-Hsing Lin, Wen-Cheng Huang, Po-Jung Tsai, Wen-Ping Chen, Dz-Chi Chen, Lu-Te Chuang
FOOD AND AGRICULTURAL IMMUNOLOGY
(2017)
Article
Cell Biology
Po-Jung Tsai, Wen-Cheng Huang, Shao-Wei Lin, Sung-Nien Chen, Hung-Jing Shen, Hsiang Chang, Lu-Te Chuang
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Tsung-Hsien Tsai, Tsung-Jung Lien, Wen-Cheng Huang, Jun-Jen Liu, Hsiang Chang, Mei-Ling Chang, Po-Jung Tsai
Article
Cell Biology
Szu-Jung Chen, Wen-Cheng Huang, Hung-Jing Shen, Ruei-Yu Chen, Hsiang Chang, Yun-Shan Ho, Po-Jung Tsai, Lu-Te Chuang
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Ya-Hsin Shih, Wen-Cheng Huang, Lie-Chwen Lin, Chin Hsu, Jong-Ho Chyuan, Tsung-Hsien Tsai, Po-Jung Tsai
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Wen-Cheng Huang, Yu-Chen Hou, Jong-Ho Chyuan, Hsiang Chang, Chi- Chang, Tsung-Hsien Tsai, Po-Jung Tsai
Summary: In this study, two cucurbitane-type triterpenoids were evaluated for their suppressive effect on Cutibacterium acnes-induced inflammatory responses. The compounds demonstrated significant inhibitory effects on the production of pro-inflammatory cytokines and reduced ear edema in mice. TCD also showed the ability to suppress the expression of specific proteins, providing further relief from inflammation.
Article
Biochemistry & Molecular Biology
Tzung-Hsun Tsai, Chi- Chang, Ya-Ling Hung, Wen-Cheng Huang, Hsiang Chang, Yueh-Hsiung Kuo, Jong-Ho Chyuan, Lu-Te Chuang, Po-Jung Tsai
Summary: The study identified charantadiol A from bitter melon leaf as a potential anti-inflammatory agent against P. gingivalis-induced inflammation. Charantadiol A effectively reduced the production of pro-inflammatory cytokines and showed inhibitory effects on periodontal inflammation in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Chih-Cheng Lin, Hsiu-Hua Lin, Hsiang Chang, Lu-Te Chuang, Chih-Yu Hsieh, Shing-Hwa Lu, Chi-Feng Hung, Jia-Feng Chang
Summary: This study compared the effects of different tea processes on immune modulation and oxidative stress in macrophages. The results showed that purple shoot tea has potential prophylactic benefits for reducing inflammation and regulating cytokine expression. Purple shoot green tea, in particular, exhibited strong antioxidant properties. Tea extracts were able to reduce inflammation and modulate immune cell responses by regulating cytokine expression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mei-Ling Chang, Yu-Ting Lin, Hsiu-Ni Kung, Yu-Chen Hou, Jun-Jen Liu, Min-Hsiung Pan, Hui-Ling Chen, Chun-Hsien Yu, Po-Jung Tsai
Summary: The triterpenoid-enriched extract (TEE) from bitter melon leaves has a protective effect against carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice, by reducing inflammatory responses and suppressing collagen deposition in liver tissues.