FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

(2012) Azadeh Arabi et al.   Nature Communications

Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study

(2011) R. Ben Abdelali et al.   BLOOD

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

(2010) L Zuurbier et al.   LEUKEMIA

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

(2010) C Kox et al.   LEUKEMIA

Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells

(2010) Ya-ning Zhao et al.   MEDICAL ONCOLOGY

Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis

(2010) Rachel Spokoini et al.   MOLECULAR ENDOCRINOLOGY

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells

(2010) G M Marshall et al.   ONCOGENE

FBXW7andNOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma

(2009) Myoung-Ja Park et al.   BRITISH JOURNAL OF HAEMATOLOGY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

(2008) V. Asnafi et al.   BLOOD

The Fbxw7/hCdc4 tumor suppressor in human cancer

(2008) YingMeei Tan et al.   CANCER LETTERS

Glycogen Synthase Kinase 3 -Mediated Serine Phosphorylation of the Human Glucocorticoid Receptor Redirects Gene Expression Profiles

(2008) A. J. Galliher-Beckley et al.   MOLECULAR AND CELLULAR BIOLOGY