Assembling the pieces of macromolecular complexes: Hybrid structural biology approaches

Investigating acid-induced structural transitions of lysozyme in an electrospray ionization source

(2015) Jong Wha Lee et al.   ANALYST

Topological Models of Heteromeric Protein Assemblies from Mass Spectrometry: Application to the Yeast eIF3:eIF5 Complex

(2015) Argyris Politis et al.   CHEMISTRY & BIOLOGY

Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling

(2014) Kamila J. Pacholarz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flexible membrane proteins: functional dynamics captured by mass spectrometry

(2014) Min Zhou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Uncertainty in integrative structural modeling

(2014) Dina Schneidman-Duhovny et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dynamic protein ligand interactions - insights from MS

(2014) Carla Schmidt et al.   FEBS Journal

A Hydrodynamic Comparison of Solution and Gas Phase Proteins and Their Complexes

(2014) Dominic Hewitt et al.   JOURNAL OF PHYSICAL CHEMISTRY B

ETD Allows for Native Surface Mapping of a 150 kDa Noncovalent Complex on a Commercial Q-TWIMS-TOF Instrument

(2014) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Ion mobility–mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility

(2014) Min Zhou et al.   Nature Chemistry

A mass spectrometry–based hybrid method for structural modeling of protein complexes

(2014) Argyris Politis et al.   NATURE METHODS

A comparative cross-linking strategy to probe conformational changes in protein complexes

(2014) Carla Schmidt et al.   Nature Protocols

Molecular Simulation-Based Structural Prediction of Protein Complexes in Mass Spectrometry: The Human Insulin Dimer

(2014) Jinyu Li et al.   PLoS Computational Biology

On the usefulness of ion-mobility mass spectrometry and SAXS data in scoring docking decoys

(2013) Ezgi Karaca et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A New Approach to Measuring Protein Backbone Protection with High Spatial Resolution Using H/D Exchange and Electron Capture Dissociation

(2013) Rinat R. Abzalimov et al.   ANALYTICAL CHEMISTRY

Gas-Phase Structure of the Histone Multimers Characterized by Ion Mobility Mass Spectrometry and Molecular Dynamics Simulation

(2013) Kazumi Saikusa et al.   ANALYTICAL CHEMISTRY

Probing the Conformational Diversity of Cancer-Associated Mutations in p53 with Ion-Mobility Mass Spectrometry

(2013) Ewa Jurneczko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mass spectrometry supported determination of protein complex structure

(2013) Thomas Walzthoeni et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-electron tomography: The challenge of doing structural biology in situ

(2013) Vladan Lučić et al.   JOURNAL OF CELL BIOLOGY

Integrative Modelling Coupled with Ion Mobility Mass Spectrometry Reveals Structural Features of the Clamp Loader in Complex with Single-Stranded DNA Binding Protein

(2013) Argyris Politis et al.   JOURNAL OF MOLECULAR BIOLOGY

Ion Mobility Spectrometry Reveals the Mechanism of Amyloid Formation of Aβ(25–35) and Its Modulation by Inhibitors at the Molecular Level: Epigallocatechin Gallate and Scyllo-inositol

(2013) Christian Bleiholder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis

(2013) Z.-Y. Kan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Structural Biology

(2013) A. B. Ward et al.   SCIENCE

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation

(2013) Carla Schmidt et al.   Nature Communications

Charge-State Dependent Compaction and Dissociation of Protein Complexes: Insights from Ion Mobility and Molecular Dynamics

(2012) Zoe Hall et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes FromEscherichia coliandPseudomonas aeruginosa

(2012) Esther van Duijn et al.   MOLECULAR & CELLULAR PROTEOMICS

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

(2012) Thomas Walzthoeni et al.   NATURE METHODS

Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations

(2012) S. Mehmood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images

(2012) J. Velazquez-Muriel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

(2012) K. Lasker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Modeling of Heteromeric Protein Complexes from Disassembly Pathways and Ion Mobility-Mass Spectrometry

(2012) Zoe Hall et al.   STRUCTURE

Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies

(2012) Daniel Russel et al.   PLOS BIOLOGY

Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation

(2011) Megan Murray Gessel et al.   BIOCHEMISTRY

Structural Analysis of Macromolecular Assemblies by Electron Microscopy

(2011) E. V. Orlova et al.   CHEMICAL REVIEWS

Putting structure into context: fitting of atomic models into electron microscopic and electron tomographic reconstructions

(2011) Niels Volkmann   CURRENT OPINION IN CELL BIOLOGY

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nanobody stabilization of G protein-coupled receptor conformational states

(2011) Jan Steyaert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Joining Forces: Integrating Proteomics and Cross-linking with the Mass Spectrometry of Intact Complexes

(2011) Florian Stengel et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural divergence of the rotary ATPases

(2011) Stephen P. Muench et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

The Polydispersity of αB-Crystallin Is Rationalized by an Interconverting Polyhedral Architecture

(2011) Andrew J. Baldwin et al.   STRUCTURE

p47phoxMolecular Activation for Assembly of the Neutrophil NADPH Oxidase Complex

(2010) Julien Marcoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Stability of Syrian Hamster Prion Protein PrP(90−231)

(2010) Megan Grabenauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Mass Spectrometry of Two Tetrameric Membrane Protein Complexes Reveals Compact Structures and Differences in Stability and Packing

(2010) Sheila C. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward an Integrated Structural Model of the 26S Proteasome

(2010) Friedrich Förster et al.   MOLECULAR & CELLULAR PROTEOMICS

Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

(2010) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

(2010) Christian Bleiholder et al.   Nature Chemistry

Interrogating viral capsid assembly with ion mobility–mass spectrometry

(2010) Charlotte Uetrecht et al.   Nature Chemistry

Integrating Ion Mobility Mass Spectrometry with Molecular Modelling to Determine the Architecture of Multiprotein Complexes

(2010) Argyris Politis et al.   PLoS One

Digital Ion Trap Mass Spectrometer for Probing the Structure of Biological Macromolecules by Gas Phase X-ray Scattering

(2009) Bryan J. McCullough et al.   ANALYTICAL CHEMISTRY

Replica Exchange Simulations of the Thermodynamics of A β Fibril Growth

(2009) Takako Takeda et al.   BIOPHYSICAL JOURNAL

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Subunit Architecture of Intact Protein Complexes from Mass Spectrometry and Homology Modeling†

(2008) Thomas Taverner et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomolecule Analysis by Ion Mobility Spectrometry

(2008) Brian C. Bohrer et al.   Annual Review of Analytical Chemistry

Integrating Diverse Data for Structure Determination of Macromolecular Assemblies

(2008) Frank Alber et al.   Annual Review of Biochemistry

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3

(2008) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Travelling wave ion mobility mass spectrometry studies of protein structure: biological significance and comparison with X-ray crystallography and nuclear magnetic resonance spectroscopy measurements

(2008) Charlotte A. Scarff et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Micelles Protect Membrane Complexes from Solution to Vacuum

(2008) N. P. Barrera et al.   SCIENCE

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE

Visualizing cells at the nanoscale

(2008) Andrew Leis et al.   TRENDS IN BIOCHEMICAL SCIENCES