Review
Biochemistry & Molecular Biology
Na-Hyun Lee, Sumin You, Ali Taghizadeh, Mohsen Taghizadeh, Hye Sung Kim
Summary: The cell membrane cloaking technique, which utilizes natural design cues, is a promising bioinspired nanotechnology for surface modification of nanoparticles. This technique can replicate complex physicochemical properties and biomimetic functions, thereby enhancing nanotherapeutic platforms. However, there are challenges to be addressed for clinical translation and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Neda Khosravi, Elham Pishavar, Behzad Baradaran, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Nanomedicine research has made significant progress, but encounters obstacles such as low drug concentration and rapid drug elimination. Stem cell membranes and stem cell-derived exosomes have emerged as promising therapeutic carriers. Combining synthetic nanoparticles with stem cell membranes enhances drug delivery. Utilizing stem cell-derived exosome membranes improves the therapeutic capability of engineered drug delivery vehicles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Qinqin Cheng, Zhefu Dai, Xiaojing Shi, Xinping Duan, Yiling Wang, Tianling Hou, Yong Zhang
Summary: Exosomes, as cell-derived extracellular vesicles, are crucial for intercellular communication and have emerged as promising nanocarriers for therapeutic applications. By genetically engineering exosomes, a new type of exosomes called GIFTed-Exos with specific functions can be created to efficiently deliver different types of protein cargos to target cells.
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Review
Biotechnology & Applied Microbiology
Mengyu Guo, Chenjie Xia, Yu Wu, Nong Zhou, Zhipeng Chen, Weidong Li
Summary: Cell membrane-coated biomimetic nanoplatforms have inherent properties that enhance drug delivery efficiency. Research progress on cell membrane biomimetic technology reveals broad prospects for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Qi Jiang, Mixue Xie, Ruyin Chen, Feifei Yan, Chanqi Ye, Qiong Li, Shuaishuai Xu, Wei Wu, Yunlu Jia, Peng Shen, Jian Ruan
Summary: CCNPs have enormous potential in cancer immunotherapy, but there are challenges in translating their effects in vitro to the clinical setting. These challenges can be addressed in the future with a focus on individualized treatment with CCNPs and CCNPs combined with other effective treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Nasrullah Jan, Asadullah Madni, Safiullah Khan, Hassan Shah, Faizan Akram, Arshad Khan, Derya Ertas, Mohammad F. Bostanudin, Christopher H. Contag, Nureddin Ashammakhi, Yavuz Nuri Ertas
Summary: This article discusses the preparation methods and applications of cell membrane-coated PLGA nanoparticles, as well as their role in cancer therapy, inflammation management, cardiovascular disease treatment, and infection control. It also highlights the challenges and future research directions of cell membrane-camouflaged nanoparticles.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Pratikshya Sa, Sanjeeb K. Sahoo, Fahima Dilnawaz
Summary: Cancer is a major global health challenge, and the tumor microenvironment plays a vital role in tumor progression and drug resistance. Targeting the tumor microenvironment is a promising approach to advance cancer nanomedicine. Recent progress in understanding the tumor microenvironment and developing responsive nanoparticles has improved pharmacokinetics and efficacy of nanomedicine in overcoming drug resistance. This review discusses the components of the tumor microenvironment and the role of nanomedicine in combating drug resistance.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Zhan Tuo, Qianyuan He, Zhanjie Zhang, Yiyu Wang, Jinfeng Sun, Qi Wei, Yu Hu, Jonathan F. Lovell, Honglin Jin, Kunyu Yang
Summary: The RP@RMs vaccine, constructed using irradiated cancer cell membrane and a nanoscale delivery system loaded with a TLR-7 agonist, showed enhanced antitumor immune response and improved efficacy of anti-PD-1 treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Yixiao Gan, Gang Zhao, Zhicheng Wang, Xingcai Zhang, Mei X. X. Wu, Min Lu
Summary: Bacterial or fungal membrane vesicles, previously considered as microbial waste, have now been found to play important roles in communication among microorganisms and between microorganisms and hosts. This review provides an updated understanding of their physiological functions, including biogenesis, mechanisms of invasion into host cells, immune stimulatory effects, and their potential applications as biomarkers, vaccines, and drug delivery platforms.
Review
Pharmacology & Pharmacy
Liming Lin, Jiaying Chi, Yilang Yan, Rui Luo, Xiaoqian Feng, Yuwei Zheng, Dongyi Xian, Xin Li, Guilan Quan, Daojun Liu, Chuanbin Wu, Chao Lu, Xin Pan
Summary: Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that disrupt cell membranes, potentially serving as future therapeutics in the drug-resistant era. Experimental evidence suggests that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Multidisciplinary
Yongkui Chen, Jikuan Qiu, Xia-Guang Zhang, Huiyong Wang, Wenhui Yao, Zhiyong Li, Qingchun Xia, Guangshan Zhu, Jianji Wang
Summary: Covalent organic frameworks (COFs) have attracted significant interest as proton-exchange membranes, chemical sensors, and electronic devices. The synthesis of a light/heat switchable COF-HNU9, capable of reversible photoisomerization and high proton conductivity, has been achieved through the incorporation of a donor-acceptor Stenhouse adduct (DASA) within the COF structure. The COF-HNU9 showed a substantial increase in proton conductivity under visible light irradiation at high humidity, demonstrating promising prospects for stimuli-responsive COFs.
Review
Biotechnology & Applied Microbiology
Wen Lei, Chen Yang, Yi Wu, Guoqing Ru, Xianglei He, Xiangmin Tong, Shibing Wang
Summary: This review discusses the manufacturing processes of cell membrane-coated nanocarriers (CMCNs) and their therapeutic applications in various drug delivery systems. It also addresses the obstacles and future prospects in this field.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rongtao Zhang, Siqiong Wu, Qian Ding, Qingze Fan, Yan Dai, Shiwei Guo, Yun Ye, Chunhong Li, Meiling Zhou
Summary: Nanotechnology has been utilized for drug delivery to sites of inflammation, with cell membrane-camouflaged nanoparticles showing promise as a novel drug-delivery platform interacting with the immune system. Encapsulating drugs within plasma membranes derived from various cells can effectively combat inflammation.
Review
Biotechnology & Applied Microbiology
Enrica Soprano, Ester Polo, Beatriz Pelaz, Pablo del Pino
Summary: Nanoparticles have demonstrated attractive capabilities in biology and medicine. However, the number of candidates reaching clinical trials or commercialization is minimal due to issues with their synthetic and foreign surface. The use of cell-derived surfaces as an alternative to artificial coatings has emerged, aiming to improve therapeutic behavior and overcome limitations of synthetic approaches. These biomimetic formulations have the potential to address challenges in drug delivery and show promise in cancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Editorial Material
Neurosciences
Nina Milosavljevic, Timothy M. Brown, Robert J. Lucas
Summary: In this issue of Neuron, Huang et al. (2021) demonstrate a new influence of light on memory, showing that prolonged exposure to bright light can enhance spatial memory in mice. They attribute this effect to a neural circuit involving the retina, ventral lateral geniculate, and reuniens nuclei.
Article
Biochemistry & Molecular Biology
Jessica Rodgers, Beatriz Bano-Otalora, Mino D. C. Belle, Sarika Paul, Rebecca Hughes, Phillip Wright, Richard McDowell, Nina Milosavljevic, Patrycja Orlowska-Feuer, Franck P. Martial, Jonathan Wynne, Edward R. Ballister, Riccardo Storchi, Annette E. Allen, Timothy Brown, Robert J. Lucas
Summary: There is no consensus on the best inhibitory optogenetic tool. Gi/o signalling is a native mechanism of neuronal inhibition, and Lamprey Parapinopsin (Lamplight) can be used for optogenetic silencing by switching between stable signalling active and inactive states with different wavelengths. The properties of Lamplight can be applied to achieve switchable neuronal hyperpolarisation and suppression of spontaneous spike firing in specific brain regions. Expressing Lamplight in ON bipolar cells can photosensitise retinas following advanced photoreceptor degeneration, showing potential for scalable, sustained, and reversible optogenetic inhibition.
Article
Computer Science, Interdisciplinary Applications
Gorana Mijatovic, Tatjana Loncar-Turukalo, Nebojsa Bozanic, Nina Milosavljevic, Riccardo Storchi, Luca Faes
Summary: This work proposes a novel approach to estimate the degree of concomitant firing between two neural units using a modified form of mutual information, providing insights into neural synchrony over time and detecting correlated and anti-correlated firing patterns. The resulting measure, denoted as CFIMI, is independent on firing rate and recording duration, sensitive to different firing patterns, and offers a new perspective on the estimation of neural synchrony.
Article
Immunology
Adam M. Blanchard, Ceri E. Staley, Laurence Shaw, Sean R. Wattegedera, Christina-Marie Baumbach, Jule K. Michler, Catrin Rutland, Charlotte Back, Nerissa Newbold, Gary Entrican, Sabine Totemeyer
Summary: This study presents the first combined global analysis of bacterial community transcripts and host immune response in healthy and diseased ovine feet during a natural polymicrobial infection state using metatranscriptomics. It reveals that footrot-affected skin has reduced diversity and increased abundances of not only the causative bacterium Dichelobacter nodosus, but also other species. Host transcriptomics show suppression of biological processes related to skin barrier function, vascular functions, and immunosurveillance in unhealthy interdigital skin, supported by histological findings.
INFECTION AND IMMUNITY
(2021)
Article
Cell Biology
Richard J. McDowell, Jessica Rodgers, Nina Milosavljevic, Robert J. Lucas
Summary: Melanopsin in mammals can signal through multiple pathways, with variations in signaling selectivity observed between species.
JOURNAL OF CELL SCIENCE
(2022)
Article
Microbiology
Hayley J. Marshall, Adam M. Blanchard, Katie R. Kelly, Jia Ni Goh, Alexander D. Williams, Lis King, Fiona Lovatt, Peers L. Davies, Sabine Totemyer
Summary: This study investigates the impact of 2% Digicur footbath on the bacterial community of ovine interdigital skin. The results suggest that 2% Digicur is not effective in reducing the load of D. nodosus, and sheep may act as reservoirs for multi-drug resistant bacteria.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cyril Rauch, Panagiota Kyratzi, Sarah Blott, Sian Bray, Jonathan Wattis
Summary: Current genome-wide association studies (GWAS) are expensive for analyzing small gene effects in complex/omnigenic traits due to the need for a large number of individuals. Genomic informational field theory (GIFT), inspired by field theory in physics, offers a different method that can extract information even with precise phenotype measurements and a small population size.
Article
Neurosciences
Christopher. A. A. Procyk, Jessica Rodgers, Egor Zindy, Robert. J. J. Lucas, Nina Milosavljevic
Summary: Light has a profound impact on mammalian physiology and behavior, and intrinsically photosensitive retinal ganglion cells (ipRGCs) play a significant role in this process. Using the computational platform BRIAN to analyze Brainbow labeled tissues, researchers found that ipRGCs maintain their normal morphology even in the degenerate retina. Additionally, they identified a cell type in the degenerate retina that has not been previously discovered in rodents.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
G. Torres, K. Vargas, J. Reyes-Velez, N. Jimenez, A. Blanchard, M. Olivera-Angel
Summary: This study aimed to describe the frequency of genotypes of Staphylococcus aureus strains isolated from intramammary infections, as well as to evaluate their ability to form biofilm under in vitro conditions. The results showed the presence of 19 different spa types, with t521, t267, and t605 being the most common. Strains from the t605 spa type exhibited the highest biofilm production. The high frequency of spa types with zoonotic potential suggests that cattle serve as an important reservoir for these clones, posing a risk to individuals in close proximity.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Evolutionary Biology
Adam Mark Blanchard, Richard David Emes, Alex David Greenwood, Nadine Holmes, Matthew William Loose, Gail Katherine McEwen, Joanne Meers, Natasha Speight, Rachael Eugenie Tarlinton
Summary: Koala populations vary in inbreeding levels and the presence of the Koala retrovirus (KoRV). These genetic differences may have significant impacts on koala population viability. Additionally, the recent colonization of the koala genome by KoRV allows for studying retroviral adaptation to vertebrate genomes and its effect on speciation, genome structure, and function. The described genome build is from a KoRV-free koala from the Southern population, providing a more contiguous genome than the previous reference and being the first KoRV polymerase-free koala genome.
GENOME BIOLOGY AND EVOLUTION
(2023)
Review
Neurosciences
Sushmitha Raja, Nina Milosavljevic, Annette E. Allen, Morven A. Cameron
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are photoreceptors located in the ganglion cell layer. They possess intrinsic photosensitivity through melanopsin and receive inputs from rods and cones. They regulate inner and outer retinal circuitry through chemical and electrical synapses, influence ganglion cell outputs, and play a vital role in the processing of image-forming vision. This research has important implications for lighting design and ocular dysfunctions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Adam M. Blanchard, Christina-Marie Baumbach, Jule K. Michler, Natalie D. Pickwell, Ceri E. Staley, Jemma M. Franklin, Sean R. Wattegedera, Gary Entrican, Sabine Totemeyer
Summary: This study found that ovine skin cells infected with M. fermentans have a reduced response to bacterial stimulation associated with footrot, providing important insights into the impact of multiple pathogens on the host response.
Article
Biotechnology & Applied Microbiology
Ternenge Apaa, Amy J. Withers, Ceri Staley, Adam Blanchard, Malcolm Bennett, Samantha Bremner-Harrison, Elizabeth A. Chadwick, Frank Hailer, Stephen W. R. Harrison, Matthew Loose, Fiona Mathews, Rachael Tarlinton
Summary: This study conducted PCR testing on two species of bats in the UK. The results showed that 44% of fecal samples and 56% of pooled samples from Rhinolophus hipposideros tested positive for a sarbecovirus coronavirus. However, no coronaviruses were detected in samples from Rhinolophus ferrumequinum, and there was no evidence of cross-species transmission.
JOURNAL OF GENERAL VIROLOGY
(2023)
Review
Veterinary Sciences
Luke A. A. McLinden, Sarah L. L. Freeman, Janet Daly, Adam Blanchard, Jeremy G. G. Kemp-Symonds, Andrew Waller
Summary: This review discusses the pathogenic mechanism, clinical manifestations, and future prevention and treatment measures of S. equi, the causative organism of strangles in equids. S. equi evolved from a commensal and occasionally opportunistic pathogen, and its success lies in its ability to cause both acute and persistent infections. Insights into the S. equi genome and lifestyle have led to advancements in diagnostic assays and the development of a safe and effective recombinant-fusion vaccine.
EQUINE VETERINARY EDUCATION
(2023)
Article
Multidisciplinary Sciences
Lamyaa Al-dalawi, Stephen P. Dunham, Cyril Rauch
Summary: Pulmonary surfactant phospholipids act as a natural barrier against viral infection and have been proven to have biophysical and immunological roles in the respiratory system. In this study, it was found that treating influenza viruses with lyso-lipids can significantly reduce their infectivity, opening up a new path for merging concepts from 'soft matter physics' and virology.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
