Designed for life: biocompatible de novo designed proteins and components

Development of a Rubredoxin-Type Center Embedded in a de Dovo-Designed Three-Helix Bundle

(2018) Alison G. Tebo et al.   BIOCHEMISTRY

Catalytic peptide assemblies

(2018) O. Zozulia et al.   CHEMICAL SOCIETY REVIEWS

The ascent of man(made oxidoreductases)

(2018) Katie J Grayson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Probing the quality control mechanism of theEscherichia colitwin-arginine translocase with folding variants of ade novo–designed heme protein

(2018) George A. Sutherland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli

(2018) Ann E Donnelly et al.   Nature Chemical Biology

Accurate computational design of multipass transmembrane proteins

(2018) Peilong Lu et al.   SCIENCE

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

(2017) Matthew J. Langton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multi-step excitation energy transfer engineered in genetic fusions of natural and synthetic light-harvesting proteins

(2017) Joshua A. Mancini et al.   Journal of the Royal Society Interface

Evolution of a designed protein assembly encapsulating its own RNA genome

(2017) Gabriel L. Butterfield et al.   NATURE

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

(2017) Eva-Maria Strauch et al.   NATURE BIOTECHNOLOGY

De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy

(2017) Nicholas F. Polizzi et al.   Nature Chemistry

Ligand-modulated conformational switching in a fully synthetic membrane-bound receptor

(2017) Francis G. A. Lister et al.   Nature Chemistry

Building membrane nanopores

(2017) Stefan Howorka   Nature Nanotechnology

Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport

(2017) Nathan H. Joh et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Principles for designing proteins with cavities formed by curved β sheets

(2017) Enrique Marcos et al.   SCIENCE

Design and engineering of water-soluble light-harvesting protein maquettes

(2017) Goutham Kodali et al.   Chemical Science

Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme

(2017) Daniel W. Watkins et al.   Nature Communications

Augmenting light coverage for photosynthesis through YFP-enhanced charge separation at the Rhodobacter sphaeroides reaction centre

(2017) Katie J. Grayson et al.   Nature Communications

A Non-natural Protein Rescues Cells Deleted for a Key Enzyme in Central Metabolism

(2017) Katherine M. Digianantonio et al.   ACS Synthetic Biology

An unusual role for the phytyl chains in the photoprotection of the chlorophylls bound to Water-Soluble Chlorophyll-binding Proteins

(2017) Alessandro Agostini et al.   Scientific Reports

Upregulation of an Artificial Zymogen by Proteolysis

(2016) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural principles for computational and de novo design of 4Fe–4S metalloproteins

(2016) Vikas Nanda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Electron transfer activity of a de novo designed copper center in a three-helix bundle fold

(2016) Jefferson S. Plegaria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Design of dinuclear manganese cofactors for bacterial reaction centers

(2016) Tien L. Olson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A suite of de novo c -type cytochromes for functional oxidoreductase engineering

(2016) Daniel W. Watkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

First principles design of a core bioenergetic transmembrane electron-transfer protein

(2016) Geetha Goparaju et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Design and engineering of a man-made diffusive electron-transport protein

(2016) Bryan A. Fry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Engineering an Artificial Flavoprotein Magnetosensor

(2016) Chris Bialas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A De Novo Virus-Like Topology for Synthetic Virions

(2016) James E. Noble et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades

(2016) Yasunori Okamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accurate de novo design of hyperstable constrained peptides

(2016) Gaurav Bhardwaj et al.   NATURE

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Designed metalloprotein stabilizes a semiquinone radical

(2016) Gözde Ulas et al.   Nature Chemistry

Controlled membrane translocation provides a mechanism for signal transduction and amplification

(2016) Matthew J. Langton et al.   Nature Chemistry

Installing hydrolytic activity into a completely de novo protein framework

(2016) Antony J. Burton et al.   Nature Chemistry

A protein constructed de novo enables cell growth by altering gene regulation

(2016) Katherine M. Digianantonio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension

(2016) James T. MacDonald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ade novoprotein confers copper resistance inEscherichia coli

(2016) Kenric J. Hoegler et al.   PROTEIN SCIENCE

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

(2016) Stephanie Berger et al.   eLife

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

(2015) Yao Zhang et al.   ACS Chemical Biology

Biomineralization of a Cadmium Chloride Nanocrystal by a Designed Symmetrical Protein

(2015) Arnout R. D. Voet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins

(2015) Rae Ana Snyder et al.   BIOCHEMISTRY

Apoprotein Structure and Metal Binding Characterization of a de Novo Designed Peptide, α3DIV, that Sequesters Toxic Heavy Metals

(2015) Jefferson S. Plegaria et al.   BIOCHEMISTRY

Assembly of water-soluble chlorophyll-binding proteins with native hydrophobic chlorophylls in water-in-oil emulsions

(2015) Dominika Bednarczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Modulation of cluster incorporation specificity in a de novo iron-sulfur cluster binding peptide

(2015) Dayn Joseph Sommer et al.   BIOPOLYMERS

Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure

(2015) Marco Chino et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

De Novo Design and Characterization of Copper Metallopeptides Inspired by Native Cupredoxins

(2015) Jefferson S. Plegaria et al.   INORGANIC CHEMISTRY

Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins

(2015) Rae Ana Snyder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Variable primary coordination environments of Cd(ii) binding to three helix bundles provide a pathway for rapid metal exchange

(2015) Alison G. Tebo et al.   Metallomics

De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy

(2015) Po-Ssu Huang et al.   Nature Chemical Biology

A De Novo Designed Metalloenzyme for the Hydration of CO2

(2014) Virginia M. Cangelosi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

De novo protein components for oxidoreductase assembly and biological integration

(2014) Daniel W Watkins et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolic engineering of carbon and redox flow in the production of small organic acids

(2014) Chandresh Thakker et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A De Novo Designed 2[4Fe-4S] Ferredoxin Mimic Mediates Electron Transfer

(2014) Anindya Roy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts

(2014) Yvonne M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational design of a self-assembling symmetrical β-propeller protein

(2014) Arnout R. D. Voet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent evolution of a bifunctionalde novoprotein

(2014) Betsy A. Smith et al.   PROTEIN SCIENCE

A designed supramolecular protein assembly with in vivo enzymatic activity

(2014) Woon Ju Song et al.   SCIENCE

De novo design of a transmembrane Zn2+-transporting four-helix bundle

(2014) Nathan H. Joh et al.   SCIENCE

The role of charge-transfer states in energy transfer and dissipation within natural and artificial bacteriochlorophyll proteins

(2014) Md. Wahadoszamen et al.   Nature Communications

Formal Reduction Potential of 3,5-Difluorotyrosine in a Structured Protein: Insight into Multistep Radical Transfer

(2013) Kanchana R. Ravichandran et al.   BIOCHEMISTRY

Reversible Phenol Oxidation and Reduction in the Structurally Well-Defined 2-Mercaptophenol-α3C Protein

(2013) Cecilia Tommos et al.   BIOCHEMISTRY

High-quality protein backbone reconstruction from alpha carbons using Gaussian mixture models

(2013) Benjamin L. Moore et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bimodal Intramolecular Excitation Energy Transfer in a Multichromophore Photosynthetic Model System: Hybrid Fusion Proteins Comprising Natural Phycobilin- and Artificial Chlorophyll-Binding Domains

(2013) Xiao-Li Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elementary tetrahelical protein design for diverse oxidoreductase functions

(2013) Tammer A Farid et al.   Nature Chemical Biology

Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling

(2013) James T. MacDonald et al.   PLoS One

Constructing a man-made c-type cytochrome maquette in vivo: electron transfer, oxygen transport and conversion to a photoactive light harvesting maquette.

(2013) J. L. Ross Anderson et al.   Chemical Science

Engineering oxidoreductases: maquette proteins designed from scratch

(2012) Bruce R. Lichtenstein et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering

(2012) Bryan S. Der et al.   BIOCHEMISTRY

Catalytic Efficiency of Enzymes: A Theoretical Analysis

(2012) Sharon Hammes-Schiffer   BIOCHEMISTRY

New currency for old rope: from coiled-coil assemblies to α-helical barrels

(2012) Derek N Woolfson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Constructing manmade enzymes for oxygen activation

(2012) Craig T. Armstrong et al.   DALTON TRANSACTIONS

Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins

(2012) Amanda J. Reig et al.   Nature Chemistry

Electron Transfer Interactome of Cytochrome c

(2012) Alexander N. Volkov et al.   PLoS Computational Biology

Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment

(2011) Saumen Chakraborty et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

(2011) Inês Chaves et al.   Annual Review of Plant Biology

Zinc-Bacteriochlorophyllide Dimers in de Novo Designed Four-Helix Bundle Proteins. A Model System for Natural Light Energy Harvesting and Dissipation

(2011) Ilit Cohen-Ofri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

(2011) Melissa L. Zastrow et al.   Nature Chemistry

De Novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth

(2011) Michael A. Fisher et al.   PLoS One

Comparing Photosynthetic and Photovoltaic Efficiencies and Recognizing the Potential for Improvement

(2011) R. E. Blankenship et al.   SCIENCE

Engineering enzymes

(2010) P. Leslie Dutton et al.   FARADAY DISCUSSIONS

De Novo Design and Molecular Assembly of a Transmembrane Diporphyrin-Binding Protein Complex

(2010) Ivan V. Korendovych et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design principles for chlorophyll-binding sites in helical proteins

(2010) Paula Braun et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

De novo design of a non-natural fold for an iron–sulfur protein: Alpha-helical coiled-coil with a four-iron four-sulfur cluster binding site in its central core

(2009) Joanna Grzyb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Designing artificial enzymes by intuition and computation

(2009) Vikas Nanda et al.   Nature Chemistry

Chemical magnetoreception in birds: The radical pair mechanism

(2009) C. T. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo backbone scaffolds for protein design

(2009) James T. MacDonald et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Synthetic biology through biomolecular design and engineering

(2008) K CHANNON et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Geometric constraints for porphyrin binding in helical protein binding sites

(2008) Christopher Negron et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS