Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression

(2017) Tiffany Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammation, Glutamate, and Glia in Depression: A Literature Review

(2015) Leah McNally et al.   CNS SPECTRUMS

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

(2012) Michael Maes et al.   BMC Medicine

Ketamine for Treatment-Resistant Unipolar Depression

(2012) Sanjay J. Mathew et al.   CNS DRUGS

The Interplay between Indoleamine 2,3-Dioxygenase 1 (IDO1) and Cyclooxygenase (COX)-2 In Chronic Inflammation and Cancer

(2012) A. Cesario et al.   CURRENT MEDICINAL CHEMISTRY

Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection

(2012) Trevor W. Stone et al.   FEBS Journal

Kynurenines: from the perspective of major psychiatric disorders

(2012) Aye M. Myint   FEBS Journal

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder

(2012) Piotr Gałecki et al.   JOURNAL OF AFFECTIVE DISORDERS

Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study

(2012) Seyed-Hesameddin Abbasi et al.   JOURNAL OF AFFECTIVE DISORDERS

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

(2012) Saravanan Kanakasabai et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis

(2012) Binu Chandran et al.   PHYTOTHERAPY RESEARCH

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

(2012) Michael Maes et al.   PSYCHIATRY RESEARCH

Neuroplastic changes in depression: A role for the immune system

(2012) Harris Eyre et al.   PSYCHONEUROENDOCRINOLOGY

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity

(2011) Hong Jiang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

(2011) Subash C Gupta et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats

(2011) Ramar Manikandan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: New pathways that underpin the inflammatory and neuroprogressive pathophysiology

(2011) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells

(2011) Jiraporn Tocharus et al.   Journal of Natural Medicines

Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis

(2011) Nitish Bhatia et al.   Journal of Natural Medicines

Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation

(2011) John Cuomo et al.   JOURNAL OF NATURAL PRODUCTS

Curcumin prevents corticosterone-induced neurotoxicity and abnormalities of neuroplasticity via 5-HT receptor pathway

(2011) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

A Curcumin Derivative, 2,6-Bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) Attenuates Prostaglandin E2 Synthesis via Selective Suppression of Cyclooxygenase-2 in IFN-g/LPS-Stimulated Macrophages

(2011) Ka-Heng Lee et al.   MOLECULES

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

(2011) Purusotam Basnet et al.   MOLECULES

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

(2011) Jonas Hannestad et al.   NEUROPSYCHOPHARMACOLOGY

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

(2011) Zhen Huang et al.   NEUROSCIENCE LETTERS

Curcumin Attenuates Aluminum-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain

(2011) Pooja Khanna Sood et al.   NEUROTOXICITY RESEARCH

Nitric oxide and major depression

(2011) Ashish Dhir et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

LPS inhibits the effects of fluoxetine on depression-like behavior and hippocampal neurogenesis in rats

(2011) Ying Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: Possible relevance to its antidepressant mechanism

(2011) Tzu Yu Lin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment

(2011) Bun-Hee Lee et al.   Psychiatry Investigation

Curcumin ameliorates reserpine-induced pain–depression dyad: Behavioural, biochemical, neurochemical and molecular evidences

(2011) V. Arora et al.   PSYCHONEUROENDOCRINOLOGY

N-acetylcysteine for major depressive episodes in bipolar disorder

(2011) Pedro V Magalhães et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

(2011) Parviz Khajehdehi et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Potentials of Curcumin as an Antidepressant

(2011) S.K. Kulkarni et al.   TheScientificWorldJOURNAL

Is Depression an Inflammatory Disorder?

(2011) Charles L. Raison et al.   Current Psychiatry Reports

GABAergic and nitriergic modulation by curcumin for its antianxiety-like activity in mice

(2010) Neeraj Gilhotra et al.   BRAIN RESEARCH

Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: Evidence of its antioxidant property

(2010) Suresh R Naik et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

An overview of curcumin in neurological disorders

(2010) SK Kulkarni et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells

(2010) In Duk Jung et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Immunomodulatory and therapeutic activity of curcumin

(2010) Raghvendra M. Srivastava et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kynurenines, neurodegeneration and Alzheimer’s disease

(2010) Zsigmond Tamas Kincses et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

(2010) Xin Fu et al.   Journal of Neuroinflammation

Curcumin Inhibits the Proteinase-Activated Receptor-2–Triggered Prostaglandin E2 Production by Suppressing Cyclooxygenase-2 Upregulation and Akt-Dependent Activation of Nuclear Factor-κB in Human Lung Epithelial Cells

(2010) Kazumi Moriyuki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Corticotropin-Releasing Hormone, Glutamate, and γ-Aminobutyric Acid in Depression

(2010) Shang-Feng Gao et al.   NEUROSCIENTIST

Protective Effect of Curcumin and its Combination with Piperine (Bioavailability Enhancer) Against Haloperidol-Associated Neurotoxicity: Cellular and Neurochemical Evidence

(2010) Mahendra Bishnoi et al.   NEUROTOXICITY RESEARCH

Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders

(2010) Susann Matthes et al.   PHARMACOLOGY

Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

(2010) Stefan Bereswill et al.   PLoS One

Glucocorticoids, cytokines and brain abnormalities in depression

(2010) Patricia A. Zunszain et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

(2010) Ann Gardner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of zinc in neurodegenerative inflammatory pathways in depression

(2010) Bernadeta Szewczyk et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

(2010) Yili Chen et al.   PSYCHIATRY RESEARCH

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

The role of serotonin receptor subtypes in treating depression: a review of animal studies

(2010) Gregory V. Carr et al.   PSYCHOPHARMACOLOGY

Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

(2010) Oguzhan Karatepe   WORLD JOURNAL OF GASTROENTEROLOGY

Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress

(2010) Balwant Rai et al.   Journal of Oral Science

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial

(2009) Shahin Akhondzadeh et al.   DEPRESSION AND ANXIETY

Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons

(2009) Nady Braidy et al.   FEBS Journal

A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

(2009) B Antony et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production

(2009) Lin Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies

(2009) D. Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats

(2009) Yu-Cheng Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

(2009) Birgul Elbozan Cumurcu et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Mitochondrial involvement in psychiatric disorders

(2008) Ling Shao et al.   ANNALS OF MEDICINE

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Antioxidant and radical scavenging properties of curcumin

(2008) Tuba Ak et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Role of Neurogenesis in Neurodegenerative Diseases and its Implications for Therapeutic Development

(2008) Andrea Abdipranoto et al.   CNS & Neurological Disorders-Drug Targets

COX-2 Inhibition in Schizophrenia and Major Depression

(2008) Norbert Muller et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits

(2008) Wu-Tein Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

(2008) Felicity Ng et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Major depression in adolescent children consecutively diagnosed with mitochondrial disorder

(2008) S. Koene et al.   JOURNAL OF AFFECTIVE DISORDERS

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

(2008) Young-Il Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Immune Tolerance of Cancer is Mediated by IDO That is Inhibited by COX-2 Inhibitors Through Regulatory T Cells

(2008) Sung Yong Lee et al.   JOURNAL OF IMMUNOTHERAPY

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma

(2008) Yong-chang Wei et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Mitochondrial Dysfunction and Psychiatric Disorders

(2008) Gislaine T. Rezin et al.   NEUROCHEMICAL RESEARCH

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

(2008) Mohit Kumar Bhutani et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice

(2008) Anil Kumar et al.   PHYTOMEDICINE

Antidepressant activity of curcumin: involvement of serotonin and dopamine system

(2008) Shrinivas K. Kulkarni et al.   PSYCHOPHARMACOLOGY

Mitochondrial Energy Depletion in Depression with Somatization

(2008) Ann Gardner et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of NCB-02, Atorvastatin and Placebo on Endothelial Function, Oxidative Stress and Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

(2008) P Usharani et al.   Drugs in research & development

The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors

(2007) Rui Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain

(2007) M BISHNOI et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR