Article
Biochemistry & Molecular Biology
Ivana Smoljan, Dijana Detel, Suncica Buljevic, Igor Erjavec, Ivana Maric
Summary: This study found that systemic administration of BMP7 can reduce the adverse effects of chronic colitis by suppressing the inflammatory response and triggering changes in the cytokine balance and RANKL/OPG system. Additionally, BMP7 has therapeutic potential in managing osteoporosis in chronic colitis and should be further evaluated for the treatment of IBD.
Article
Cell Biology
Lishan Zhang, Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
Summary: A novel missense mutation (NM_000523: exon2: c.G917T: p.R306L) of Hoxd13 gene was identified in a Chinese family with synpolydactyly (SPD). Mice carrying the corresponding Hoxd13 mutation exhibited synpolydactyl phenotype. Further analysis revealed that this mutation promoted osteoclast differentiation and bone loss by regulating Smad5/p65/c-Fos/Rank axis, providing new insights into the development of SPD.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Wozniak, Anna Borkowska, Marta Jastrzebska, Marcin Sochal, Ewa Malecka-Wojciesko, Renata Talar-Wojnarowska
Summary: In recent years, it has been observed that the concentration of erythroferrone and BMP-6 are significantly higher in patients with inflammatory bowel diseases, especially those with anemia. This finding highlights the importance of further research on this topic.
Review
Biochemistry & Molecular Biology
Ming-Li Zou, Zhong-Hua Chen, Ying-Ying Teng, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Yi Feng, Xia Li, Rui-Sheng Xu, Feng-Lai Yuan
Summary: Bone remodeling is a continuous process crucial for maintaining skeletal homeostasis, with Smad signaling pathway playing a key role in regulating osteoblast and osteoclast functions during this process. Targeting Smad signaling pathway could be a promising therapeutic strategy for treating osteoporosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon, Hiromasa Hirai, Hongying Tian, Ivan Alferiev, Michael Chorny, Satoru Otsuru, Seiji Okada, Masahiro Iwamoto
Summary: BMPs have been used clinically for bone formation in musculoskeletal disorders, but high doses can lead to adverse events. A potent antagonist of RAR gamma was found to enhance BMP-induced bone formation, leading to increased bone volume and thickness, as well as promoting chondrogenic gene expression. This suggests potential for improving BMP-2 based bone regeneration procedures in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Mohamed Al-Shabrawey, Khaled Hussein, Fang Wang, Ming Wan, Khaled Elmasry, Nehal Elsherbiny, Heba Saleh, Paul B. Yu, Amany Tawfik, Ahmed S. Ibrahim
Summary: The study found that BMP2 and high glucose affect the function of retinal endothelial cells through a non-canonical inflammatory pathway, and inhibiting the BMP2 signaling pathway may be a potential therapeutic intervention to preserve the barrier function of retinal endothelial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Zhuo Xie, Gaoshi Zhou, Mudan Zhang, Jing Han, Ying Wang, Xiaoling Li, Qirui Wu, Manying Li, Shenghong Zhang
Summary: Inflammatory bowel diseases (IBDs) are chronic intestinal disorders characterized by relapsing inflammation, which can lead to colitis-associated colorectal cancer. Biologic agents targeting specific pathways in IBD pathogenesis have shown more success than conventional therapies. Bone morphogenetic proteins (BMPs) and BMP antagonists have been identified as promising candidates for IBD treatment. This review provides an updated overview on the involvement of BMPs and BMP antagonists in IBD pathogenesis and their role in regulating intestinal stem cells, highlighting potential therapeutic strategies.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Cai-Ping Yan, Xing-Kuan Wang, Ke Jiang, Chong Yin, Chao Xiang, Yong Wang, Chaoyu Pu, Lu Chen, Yu-Ling Li
Summary: Bone defects are a global public health problem, and the available methods for inducing bone regeneration are limited. β-ecdysterone, a plant sterol similar to estrogen, has been found to promote bone regeneration by enhancing osteoblast differentiation and activating the BMP-2/Smad/Runx2/Osterix pathway. This study provides a new direction for osteogenic differentiation and offers novel therapeutic strategies for treating bone defects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Medicine, General & Internal
Edyta Maria Tulewicz-Marti, Konrad Lewandowski, Grazyna Rydzewska
Summary: Bone mineral alterations are common in patients with inflammatory bowel disease (IBD), especially in those with Crohn's disease (CD). This may be due to poor absorption, making CD patients vulnerable to changes in bone mineralization. Vitamin D supplementation is crucial, especially when taking corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Review
Cell Biology
Mengmeng Liu, Graham Goldman, Mary MacDougall, Shuo Chen
Summary: BMP signaling plays a crucial role in dentin development, regulating the differentiation and gene expression of odontoblasts through canonical and non-canonical Smad signaling pathways. Dysregulation of BMP signaling leads to tooth disorders, and studies in mice with BMP signaling-associated gene mutations or knockouts have provided insights into the underlying networks. This review summarizes recent advances in understanding BMP signaling in odontoblast differentiation and dentin formation, including the expression of BMPs, receptors, and downstream genes, as well as the structures of BMPs, receptors, antagonists, and their association with dentin defects.
Review
Neurosciences
Gwenvael Le Dreau
Summary: This mini-review summarizes the impact of bone morphogenetic proteins (BMPs) on various aspects of vertebrate central nervous system (CNS) formation and highlights the crucial role of canonical BMP activity in the amplification and maintenance of neural stem cells. These findings suggest the evolutionary conservation of this function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Jun Sik Lee, Hyung Keun Kim
Summary: BFP-4 induces stronger osteogenic differentiation of BMSCs compared to BMP-7, as well as enhancing ALP activity, calcium concentration, and osteogenic factor production. This suggests that BFP-4-stimulated cell therapy may be a more efficient and cost-effective approach to bone regeneration and formation than BMP-7-based therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Tamara Turk Wensveen, Dora Gasparini, Dario Rahelic, Felix M. Wensveen
Summary: The recent research sheds light on how T2D impairs immune responses to viral infection and how virus-induced activation of the immune system increases the risk of developing T2D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec, Aymen I. Idris
Summary: TRAF6 inhibitors may be beneficial in managing the inflammatory component of bone disorders, but they may not provide protection against local or systemic bone loss unless combined with anti-resorptive therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Inga Kavazovic, Mia Krapic, Ammarina Beumer-Chuwonpad, Bojan Polic, Tamara Turk Wensveen, Niels A. Lemmermann, Klaas P. J. M. van Gisbergen, Felix M. Wensveen
Summary: Type 2 diabetes leads to impaired antiviral and anticancer capacity of memory CD8 T cells due to hyperglycemia, rather than hyperinsulinemia, in the context of obesity.
Article
Biochemistry & Molecular Biology
Ivan Banovac, Lovorka Grgurevic, Viktorija Rumenovic, Slobodan Vukicevic, Igor Erjavec
Summary: Bone morphogenetic protein 3 (Bmp3) deletion was found to affect skeleton development until adulthood, leading to increased cortical and trabecular bone parameters in young and adult mice of both sexes, while delayed mineralization of the epiphyseal growth plate was observed in adult Bmp3(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Slobodan Vukicevic, Andrea Colliva, Vera Kufner, Valentina Martinelli, Silvia Moimas, Simone Vodret, Viktorija Rumenovic, Milan Milosevic, Boris Brkljacic, Diana Delic-Brkljacic, Ricardo Correa, Mauro Giacca, Manuel Maglione, Tatjana Bordukalo-Niksic, Ivo Dumic-Cule, Serena Zacchigna
Summary: This study demonstrates that the inhibition of the specific isoform of Bone Morphogenetic Protein 1 (BMP1.3) by a monoclonal antibody can reduce cardiac fibrosis and provide cardioprotection through inhibiting the Transforming Growth Factor beta pathway and inducing BMP5. It suggests the therapeutic potential of anti-BMP1.3 antibodies in preventing cardiomyocyte apoptosis, reducing collagen deposition, and preserving cardiac function after ischemia.
NATURE COMMUNICATIONS
(2022)
Article
Medical Laboratory Technology
Merica Aralica, Vesna Supak Smolcic, Tamara Turk Wensveen, Snjezana Hrabric Vlah, Mihael Selar, Lidija Bilic Zulle
Summary: Vitamin D testing is excessively used in clinical practice, despite clinical guidelines statements against population screening for vitamin D deficiency. This study aimed to assess the number of unsupported vitamin D tests and associated financial burden on publicly funded healthcare.
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vedrana Krusic Alic, Mladenka Malenica, Masa Biberic, Sinisa Zrna, Lara Valencic, Aleksandar Suput, Lada Kalagac Fabris, Karmen Wechtersbach, Nika Kojc, Mario Kurtjak, Natalia Kucic, Kristina Grabusic
Summary: Extracellular vesicles (EVs) are cell-secreted membranous nanoparticles present in body fluids with great diagnostic potential. This study compared four types of size exclusion chromatography (SEC) techniques to isolate EVs from the cerebrospinal fluid (CSF) of patients with severe traumatic brain injury. It was found that Sepharose CL-6B was the most effective method for isolating EVs from CSF and separating them from lipoproteins.
Article
Immunology
Dora Gasparini, Inga Kavazovic, Igor Barkovic, Vitomir Maricic, Viktor Ivanis, Dijana Travica Samsa, Viktor Persic, Bojan Polic, Tamara Turk Wensveen, Felix M. Wensveen
Summary: This study investigated the impact of freediving on the immune system and found that cytotoxic immune cells transiently change their functional profile to restrict tissue damage after freediving.
IMMUNOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Nikola Stokovic, Natalia Ivanjko, Marko Pecin, Igor Erjavec, Ana Smajlovic, Marina Milesevic, Sven Karlovic, Hrvoje Capak, Zoran Vrbanac, Drazen Maticic, Slobodan Vukicevic
Summary: This study investigated the long-term outcome of ABGS with synthetic ceramics in rabbit spinal fusion. The results showed that the chemical composition and size of the ceramic particles had an impact on the fusion outcome, with smaller particles containing high proportion of HA resulting in increased bone volume.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Nikola Stokovic, Natalia Ivanjko, Viktorija Rumenovic, Anita Breski, Kuber T. Sampath, Mihaela Peric, Marko Pecina, Slobodan Vukicevic
Summary: This study evaluated different commercially available synthetic ceramic particles as compression-resistant matrix (CRM) added to Osteogrow implants. The results showed that Osteogrow-C implants with different ceramic particles induced the formation of bone-ceramic structure and promoted bone formation. Highly porous Vitoss ceramic demonstrated the highest bone volume, while Vitoss and ChronOs ceramics increased the number of trabeculae, and BAM and Dongbo ceramics increased the thickness of trabeculae.
INTERNATIONAL ORTHOPAEDICS
(2022)
Review
Biochemistry & Molecular Biology
Kristina Pilipovic, Anja Harej Hrkac, Natalia Kucic, Jasenka Mrsic-Pelcic
Summary: CNS injury, caused by trauma or ischemia/hypoxia, is a major cause of mortality and morbidity. Despite numerous studies, no effective neuroprotective strategies have been found for brain trauma or ischemia treatment. The use of experimental models, both in vivo and in vitro, has raised questions in the study of CNS injury. Ethical concerns have led to the encouragement of in vitro studies using cells and tissues. This review discusses commonly used in vitro models and cellular platforms for research on traumatic brain injury and cerebral ischemia, and proposes future strategies for better translational outcomes from bench to bedside.
Article
Medicine, Research & Experimental
Natalia Ivanjko, Nikola Stokovic, Marina Milesevic, Viktorija Rumenovic, Reinhard Windhager, Kuber T. Sampath, Natasa Kovacic, Danka Grcevic, Slobodan Vukicevic
Summary: Bone morphogenetic proteins (BMPs) require a suitable delivery system for treating spinal and bone defects. INFUSE, the only commercially available BMP-based device, has major disadvantages. A novel device called OSTEOGROW, containing BMP6 dispersed within autologous blood coagulum, shows promising results for bone regeneration. This study compares the release dynamics and cellular response of OSTEOGROW and INFUSE implants and demonstrates that OSTEOGROW is superior in inducing bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Meeting Abstract
Cell & Tissue Engineering
N. Stokovic, N. Ivanjko, M. Pecin, A. Smajlovic, N. Ivkic, H. Capak, Z. Vrbanac, D. Vnuk, D. Maticic, S. Vukicevic
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Slobodan Vukicevic
TISSUE ENGINEERING PART A
(2022)